http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078537-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46583b49082bd012bce6401fb6a842c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 |
| filingDate | 2010-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078537-A1 |
| titleOfInvention | HITEROCICLIC DERIVATIVES OF INDOL LIGANDOS OF THE RECEPTOR OF STROGENS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME FOR THE TREATMENT OF DISEASES ASSOCIATED WITH THE CENTRAL NERVOUS SYSTEM, OSTEOPOROSIS, CANCERES AND OTHER PATHOLOGIES |
| abstract | Claim 1: A compound of formula (1) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of said ester or said amide, and a solvate of said ester, said amide or salt, in which R1 is selected from the group consisting of halogen, cyano, nitro, ORA, N (RB) 2, -C (O) C1-4 alkyl, -SO2 C1-4 alkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl , C1-6 haloalkyl, C1-6 dihaloalkyl, C1-6 trihaloalkyl, C2-6 haloalkenyl, C2-6 dihaloalkenyl, C2-6 trihaloalkenyl, C1-6 cyanoalkyl, C1-4 alkoxy C1-6 alkyl, C3-8 cycloalkyl, cycloalkyl C3-8C1-6alkyl, phenyl, benzyl, and 5-10 membered heterocyclyl, wherein said phenyl, benzyl or heterocyclyl group may be unsubstituted or substituted with between 1 and 3 substituents, each substituent being independently selected from the group consisting of ORA , halogen, cyano, nitro, -C (O) C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 dihaloalkyl and trihaloalk C1-6 yl; R2 is selected from the group consisting of cyano, nitro, N (OH) 2, -CHO, -CH = N-OH, -C (O) C1-4 alkyl optionally substituted with between 1 and 3 halogens, -SO2 C1-4 alkyl , -C (O) NH-OH, -C (NH2) = N-OH, -C (CO2H) = N-OH, -C (NH2) = NH, -C (NH2) = N-NH2, -NH -C (NH2) = NH, -NH-C (O) NH2, -N = C (-NH-CH2CH2-NH-), -S-CN, -SC (NH2) = NH, -SC (NH2) = N-OH, -CO2H, -CH (OH) CO2H, -C (O) N (RC) 2, -SO2 C1-6 alkyl, SO2N (RC) 2, -C (O) -C (O) -NH2, -CH2NH-CONH2, -SO2ORC, -C (O) CO2H, -CH2SO3H and 5-10 membered heterocyclyl wherein said heterocyclyl group may be unsubstituted or substituted with between 1 and 3 substituents each substituent being independently selected from the group consisting of ORA , halogen, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 haloalkyl, C 1-6 dihaloalkyl and C 1-6 trihaloalkyl; each of R3, R4, R5, R6, R7, R8, R9 and R10 is independently selected from the group consisting of hydrogen, ORA, halogen, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 dihaloalkyl and C1-6 trihaloalkyl; each RA is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-6 alkyl, phenyl, benzyl and 5-10 membered heterocyclyl, each optionally substituted with between 1 and 3 halogen atoms; and each RB is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-6 alkyl, phenyl, benzyl and 5-10 membered heterocyclyl , each optionally substituted with between 1 and 3 halogen atoms; and each RC is independently selected from the group consisting of hydrogen and C1-6 alkyl. |
| priorityDate | 2009-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.