http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078535-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_46583b49082bd012bce6401fb6a842c3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 |
| filingDate | 2010-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078535-A1 |
| titleOfInvention | PIRROLO DERIVATIVES [2,3-B] PYRIDINE LIGANDOS OF STROGEN RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF THE OSTEOPOROSIS AND DISEASES OF THE CENTRAL NERVOUS SYSTEM, AMONG OTHER |
| abstract | Claim 1: A compound of the formula (1) or a pharmaceutically acceptable ester, amide, solvate or salt thereof, including a salt of said ester or amide, and a solvate of said ester, amide or salt, in which one of one of A, B, D and E represents nitrogen, and the other three of A, B, D and E represent CR3, CR4 and CR5; R1 is selected from the group consisting of hydrogen, halogen, cyano, nitro, ORA, N (RB) 2, -C (O) C1-4 alkyl, -SO2-C1-4 alkyl, C1-6 alkyl, C2-6 alkenyl C2-6 alkynyl, C1-6 haloalkyl, C1-6 dihaloalkyl, C1-6 trihaloalkyl, C2-6 haloalkenyl, C2-6 dihaloalkenyl, C2-6 trihaloalkenyl, C1-6 cyanoalkyl, C1-4alkoxy C1-6 alkyl, cycloalkyl C3-8, C3-8 cycloalkylC 1-6 alkyl, benzyl and 5-10 membered heterocyclyl, wherein said phenyl, benzyl or heterocyclyl group may be unsubstituted or substituted with 1 to 3 substituents, each of which is independently selected from the group consisting of ORA, halogen, cyano, nitro, -C (O) C1-4 alkyl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C1-6 dihaloalkyl and C1- trihaloalkyl 6; R2 is selected from the group consisting of halogen, cyano, nitro, ORC, N (RB) 2, N (OH) 2, -CHO, -CH = N-OH, -C (O) C1-4 alkyl optionally substituted with 1 at 3 halogens, -SO2-C1-4 alkyl, -C (O) NH-OH, -C (NH2) N = OH, -C (CO2H) = N-OH, -C (NH2) = NH, -C (O-C1-4 alkyl) = NH, -C (NH2) = N-NH2, -NH-C (NH2) = NH, -NH-C (O) NH2, -N = C (-NH-CH2CH2- NH-), -S-CN, -SC (NH2) = NH, -SC (NH2) = N-OH, -CO2H, -CH2-CO2H, -CH (OH) CO2H, -C (O) N (RC ) 2, SO2N (RC) 2, -C (O) -C (O) -NH2, -CH2NH-CONH2, NHSO2RB, -C (O) CO2H, SO3H, CH2SO3H and 5-10 membered heterocyclyl wherein said heterocyclyl group it may be unsubstituted or substituted with 1 to 3 substituents, each of which is independently selected from the group consisting of ORA, halogen, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1 haloalkyl -6, C1-6 dihaloalkyl and C1-6 trihaloalkyl; each of R3, R4, R5, R6, R7, R8 and R9 is independently selected from the group consisting of hydrogen, ORA, halogen, cyano, nitro, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, haloalkyl C1-6, dihaloalkyl C1-6 and trihaloalkyl C1-6; each RA is independently selected from the group consisting of hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-8 cycloalkyl, C3-8 cycloalkyl C1-6 alkyl, phenyl, benzyl and heterocyclyl of 5 - 10 members, each of which is optionally substituted with 1 to 3 halogen atoms; each RB is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkyl, C 1-6 alkyl and 5-10 membered heterocyclyl, each of which is optionally substituted with 1 to 3 halogen atoms; and each RC is independently selected from the group consisting of hydrogen and C1-6 alkyl. |
| priorityDate | 2009-10-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 30.