| abstract |
An isolated antibody that binds to a gammaC domain of fibrin or fibrinogen is provided. In several aspects, the antibody inhibits microglial adhesion to the gammaC domain of fibrin or fibrinogen, inhibits the binding of Mac-1 to the gammaC domain of fibrin or fibrinogen, and / or suppresses the clinical symptoms of experimental autoimmune encephalomyelitis (EAE). Various methods of using the antibodies, pharmaceutical compositions, kits, vectors, cells comprising the vectors and the methods of generating the antibody are provided. |