http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078351-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-96 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| filingDate | 2010-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078351-A1 |
| titleOfInvention | HSL INHIBITORS FOR DIABETES TREATMENT |
| abstract | Obtaining process, pharmaceutical compositions and uses. Claim 1: Compound of the formula (1) wherein R1 is dimethylpropyl, dimethylbutyl, cyclopropylalkyl, pyrazolyl, methyltrifluoromethyl-1H-pyrazolyl, morpholinyl, phenyl, 2-chlorophenyl, 4-methylphenyl or 4-methoxyphenyl; R2 is hydrogen, alkyl, hydroxyalkyl or alkoxyalkyl; R3 is hydrogen, alkyl, hydroxyalkyl or alkoxyalkyl; R4 is hydrogen, halogen, alkyl, hydroxyalkyl or alkoxyalkyl; R5 is hydrogen or alkyl; R6 is 2,3-dihydro-benzofuranyl, alkylpyridin-3-yl, haloalkoxypyridin-3-yl, pyridazinyl, alkoxypyridazinyl, alkyl-trifluoromethyl-1H-pyrazolyl, phenyl or substituted phenyl, said substituted phenyl is a substituted phenyl at position 4 by a substituent selected from chlorine, isopropyl, hydroxyalkyl, isopropoxy, cycloalkylalkoxy, haloalkoxy, haloalkoxyalkyl, alkoxycarbonylalkoxy, carboxyalkoxy, hydroxyalkoxy, alkoxyhaloalkoxy and hydroxyhaloalkoxy and, said phenyl substituted in the 4-position is also optionally substituted by a independently substituted fluor trifluoromethoxy, alkoxycarbonylalkoxy and hydroxyalkoxycarbonyl, but in the case, where R6 is phenyl or phenyl substituted in the 4-position by chlorine, then A2 is G; A1 is carbonyl or -S (O) 2-; A2 is a single bond, -CH2CH2- or G; G is a remainder of formula (2); n is the number zero, 1, 2, 3, 4 or 5; and its pharmaceutically acceptable salts; with the proviso that 1- (toluene-4-sulfonyl) -piperidine-4-carboxylic acid (4-trifluoromethoxy-phenyl) -amide is excluded; 1- (Toluene-4-sulfonyl) -piperidine-4-carboxylic acid [2- (4-difluoromethoxy-phenyl) -ethyl] -amide; 1-Benzenesulfonyl-piperidine-4-carboxylic acid (4-iso-propyl-phenyl) -amide; 1- (4-Methoxy-benzenesulfonyl) -piperidine-4 (1- (4-methoxy-benzenesulfonyl) -piperidine-4-acid (4-methoxy-benzenesulfonyl) -piperidine-4-acid (4-methoxy-benzenesulfonyl) -piperidine-4-acid (4-methoxy-benzenesulfonyl) -piperidine-4 -carboxylic; 1- (4-Methoxy-benzenesulfonyl) -piperidine-4-carboxylic acid (4-methoxy-benzenesulfonyl) -piperidine-4-carboxylic acid (4-methoxy-benzenesulfonyl) -piperidine-4-carboxylic acid (1-benzenesulfonyl-piperidine-4-carboxylic acid; 1- (4-Methoxybenzene) 1- (4-methoxy-benzene) (1- (4-methoxy-benzene) acid 1- (4-methoxy-benzene) acid (4-methoxy-benzene) sulfonyl) -piperidine-4-carboxylic acid; 1-benzoyl-piperidine-4-carboxylic acid (4-isopropyl-phenyl) -amide; 1- (2-chloro-benzoyl acid (4-isopropyl-phenyl) -amide) ) 1-Benzenesulfonyl-piperidine-4-carboxylic acid (1-phenyl-cyclo-pentylmethyl) -amide (1-phenyl-cyclo-pentylmethyl) -amide 1- (toluene-4-sulfonyl) -piperidine-4-carboxylic acid; ) -piperidine-4-carboxylic. |
| priorityDate | 2009-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 49.