http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078144-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbd25a3ffb36cff5ec16031e98810efc |
| filingDate | 2010-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9b842d3d1255a84b9e88b7383705556 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a35c536b9d277edb8aab15d5f6614fca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2eabb8f04a8018045fcec1da35da18dd |
| publicationDate | 2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078144-A1 |
| titleOfInvention | HYDROGENATION OF IMINAS, INTERMEDIARIES AND THE PROCESS OF OBTAINING |
| abstract | Claim 1: A process for the asymmetric hydrogenation of an imine having the formula (1): to obtain an amine having the formula (2): characterized in that said process comprises contacting said imine having the above formula 1 with hydrogen at elevated pressure in a predetermined organic solvent in the presence of a catalyst system; said catalyst system comprises a complexed ligand to a metal selected from iridium and rhodium or a salt thereof; wherein said ligand is selected from a group comprising (a) [(1R, 2R, 3S) 1-dimethyl-2,3-bis (diphenylphosphinomethyl) cyclopentyl] methanol; (b) (1S, 4S, 11R) -1,11-bis - [(diphenylphosphanyl) -methyl] -11-methyl-1,2,3,4-tetrahydro-1,4-methane-phenazin; (c) (R) -3-di- (3,5-dimethylphenyl) phosphino-2- (4-diphenylphosphino-2,5-dimethylthienyl-3) -1,7,7-trimethylbicyclo- [2.2.1] - hept-2-eno; (d) (S) -2 - [(o-diphenylphosphino) -phenyl] -1-diphenylphosphino-ferrocene; (e) (S) -1- (diphenylphosphino) -2- (S) - (o-diphenylphosphino-alpha-methoxybenzyl) ferrocene; (f) (+) - (S) -N, N-dimethyl1 - [(R) -1 ', 2-bis- (diphenylphosphino) -ferrocenyl] -ethylamine; and (g) [(S) -1 - [(R) -2-diphenylphosphino) ferrocenyl] -ethyl-di (cyclohexyl) -phosphine. Claim 3: A process for the preparation of a compound of formula (3) characterized in that it comprises: (i) reacting a compound of formula (4): with methoxyacetone having the formula CH3OCH2 C (O) CH3 to obtain a compound imine of formula 1; (ii) asymmetrically hydrogenate said imine having the formula (1): to obtain an amine having the formula (2): contacting said imine having the above formula 1 with hydrogen at elevated pressure in a predetermined organic solvent in the presence of a catalyst system; wherein said catalyst system comprises a complexed ligand to a metal selected from iridium and rhodium or a salt thereof; wherein said ligand is selected from a group comprising (a) [(1R, 2R, 3S) -1,2-dimethyl-2,3-bis (diphenylphosphinomethyl) cyclopentyl] methanol; (b) (1S, 4S, 11R) -1,11-bis - [(diphenylphosphanyl) -methyl] -11-methyl-1,2,3,4-tetrahydro-1, 4-methane-phenazin; (c) (R) -3-di- (3,5-dimethylphenyl) phosphino-2- (4-diphenylphosphino-2,5-dimethylthienyl-3) -1,7,7-trimethylbicyclo- [2.2.1] - hept-2-eno; (d) (S) -2 - [(o-diphenylphosphino) -phenyl] -1-diphenylphosphino-ferrocene; (e) (S) -1- (diphenylphosphino) -2- (S) - (o-diphenylphosphino-alpha-methoxybenzyl) ferrocene; (f) (+) - (S) -N, N-dimethyl-1 - [(R) -1 ', 2-bis- (diphenylphosphino) -ferrocenyl] ethylamine; and (g) [(S) -1 - [(R) -2-diphenylphosphino) ferrocenyl] -ethyl-di (cyclohexyl) -phosphine and (iii) reacting said amine having formula 2 with chloroacetyl chloride in the presence of a base in a non-polar solvent at a predetermined temperature. Claim 19: A compound of formula (5) characterized in that it is produced in accordance with the process claimed in any preceding claim. |
| priorityDate | 2010-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.