http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078124-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-18 |
| filingDate | 2010-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42981c31087180f43e2fb210e7a4688d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7a3af4e28164776a8f763f218b609ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fdaa8fc4b0459113c97f11c89d5c62f9 |
| publicationDate | 2011-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078124-A1 |
| titleOfInvention | STEREOSELECTIVE SYNTHESIS OF CERTAIN SPIRITS REPLACED WITH TRIFLUOROMETILO |
| abstract | Claim 1: A process for the synthesis of a compound of formula (10) wherein R1 is an aryl group substituted with one to three substituent groups, wherein each substituent group of R1 is independently C1-5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl , halogen, carboxy, cyano or trifluoromethyl, where each R1 substituent group is optionally independently substituted with one to three substituents selected from C1-3 alkyl, C1-3 alkoxy, phenyl and alkoxyphenyl; and each of R2 and R3 is independently C1-5 alkyl characterized in that it comprises: (a) reacting a dioxaborolane of formula (A) with a trialkylsilyl alkyl of formula (B), in a suitable solvent, in the presence of a suitable base with or without a metal halide, such as magnesium chloride and subsequently adding acetyl chloride to provide an alkynyl borolane of formula (C), (b) reacting the alkynyl borolane of formula (C) with a suitable trifluoromethyl ketone of formula (D), in the presence of an organometallic complex generated from the reaction of dialkyl zinc and a suitable N-alkyl-L-proline, in a suitable solvent, at a suitable temperature, and subsequently adding a suitable acid, such as acid phosphoric, to the reaction mixture to form a mixture of trimethylsilyl alkynes of formula (E) and (E '), (c) reacting the trimethylsilyl alkyne of formula (E) or (E') with a suitable base such as hydroxide sodium or a base of a L-oxide, at a suitable temperature, to provide a compound of formula (10) or (10 '), respectively. |
| priorityDate | 2009-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.