http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-076492-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_985e586742507c77adffd57be9bc530e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| filingDate | 2010-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-06-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-076492-A1 |
| titleOfInvention | 11 BETA CYCLE INHIBITORS - HYDROXIESTEROID DEHYDROGENASE 1 |
| abstract | Compounds derived from 1,3-oxazin-2-one of formulas (1) and (2), pharmaceutically acceptable salts thereof and pharmaceutical compositions thereof, which are useful for the therapeutic treatment of diseases associated with modulation or 11b-HSD1 inhibition in mammals. Pharmaceutical compositions of these compounds and their use in the reduction or control of cortisol production in a cell or the inhibition of the conversion of cortisone to cortisol in a cell. Claim 1: A hydrate of a compound represented by a structural formula selected from (1) and (2); or a pharmaceutically acceptable salt thereof, wherein: G1 is C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, halogen, cyano or nitro; n is 0, 1 or 2; G2a is C1-4 alkyl, C1-2 haloalkyl, C3-4 cycloalkyl or C3-4 cycloalkyl-C1-2 alkyl; G2b is hydrogen, methyl or ethyl; R1 is methyl or ethyl; R2 is phenyl or fluorophenyl; and R3 is 2-hydroxy-2-methylpropyl or 2-cyano-2-methylpropyl. |
| priorityDate | 2009-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.