http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-076098-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28e3113097dd6d28720572e47f2f2407 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-94 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 |
| filingDate | 2010-03-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c06bb930f51347cff3316d2af7f0f4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3166889467655bf4fa631789e268a34e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08eb1c585b070d5c846f702711ea57f8 |
| publicationDate | 2011-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-076098-A1 |
| titleOfInvention | BENZOFURAN DERIVATIVES |
| abstract | These compounds are used in the treatment of CNS diseases. Claim 1: A compound characterized by the following formula (1) wherein Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring; R1 and R2 are the same or different from each other, and represent a hydrogen atom or an optionally substituted lower alkyl; R3 and R4 are the same or different from each other, and represent a hydrogen atom or a halogenated or non-halogenated lower alkyl; R5 to R7 are the same or different from each other, and represent a hydrogen atom, a halogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted aliphatic cyclic hydrocarbon group, optionally substituted aryl, an optionally substituted heterocyclic ring, optionally substituted amino, or acyl; and ------ represents a single bond or a double bond, where: R2 and R3 do not exist when carbon atoms respectively adjacent to R2 and R3 form a double bond, and there is no case that all R1 to R7 are hydrogen atoms; and R1 and R2 can form a ring together with a contiguous carbon atom; or a salt thereof, with the proviso that: (a) the compound where at least one of R1 to R7 is a substituent represented by formula (2) where: Ra1 represents a hydroxy, or an amino that may be substituted with alkyl C1-6; Ra2 represents carbonyl or an optionally substituted methylene, Ra3 represents an optionally substituted heterocyclic ring; Ra4 represents a bond, or a methylene which may be substituted with a substituent selected from C1-5 alkyl, C5-15 arylalkyl, and C3-5 spirocycloalkyl; and Ra5 represents a hydrogen atom or a substituent; (b) the compound where at least one of R5 and R6 is a substituent represented by the formula (3) where: X represents a sulfur atom or an oxygen atom; Rb1 represents a substituent; and Rb2 represents a hydrogen atom, a halogen atom, or a saturated heterocyclic ring containing nitrogen; (c) the compound where the partial structural formula (4) of the formula (1) is the formula (5) where: Rx1 and Rx2 are the same or different from each other, and represent a substituent; the Ax Ring represents a piperazine ring that can be substituted with a substituent selected from alkyl and alkoxyalkyl; (d) the compound where ring A represents a homopiperazine ring, and -------- represents a double bond; (e) the compound where the partial structural formula (4) of the formula (1) is the formula (6) where: Ry1 to Ry8 are the same or different from each other, and represent a hydrogen atom or a substituent, and - ---- represents a double bond; (f) the compound where the partial structural formula (4) of the formula (1) is the formula (7) where: Rz1 represents C2-4 alkylene; Rz2 represents an optionally substituted indole-3-yl; (g) the following compounds: N - {[4 - ({Cyclohexyl [3-methyl-5-morpholine-1-benzofuran-2-yl] methyl} amino) phenyl] carbonyl} -N-methyl-beta-alanine, [3-Methyl-5-morpholine-1-benzofuran-2-yl] methanol, Cyclohexyl [3-methyl-5-morpholine-1-benzofuran-2-yl] methanol, N - {[4 - ({Cyclohexyl) ethyl ester [3-methyl-5-morpholine-1-benzofuran-2-yl] methyl} amino) phenyl] carbonyl} -N-methyl-beta-alanine, 2- [4- (6-Amino-2,3-dihydro- 1-benzofuran-5-yl) piperazin-1-yl] acetamide, 1- [2- (Methoxymethyl) -2,3-dihydro-1-benzofuran-5-yl] piperazine, 1- [6-Fluoro-2- (methoxymethyl) -2,3-dihydro-1-benzofuran-5-yl] piperazine, [6-Fluoro-5- (piperazin-1-yl) -2,3-dihydro-1-benzofuran-2-yl] methanol , [5- (Piperazin-1-yl) -2,3-dihydro-1-benzofuran-2-yl] methanol, and (h) 4- (2,3-dihydro-2,3,4,7-tetramethyl -5-benzofuranyl) morpholine are excluded. |
| priorityDate | 2009-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.