http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-075868-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_132aa5ddba376cda52c2bedb26765245 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 |
| filingDate | 2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c85e5e2b61412a76be7a0909aeba3054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_050a6cc64965a859fb3d6aae18d336ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4cc1b9a5a0d6954304cb78a8f5da7fd7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a3dd7db9c442d78e10f715e8a2b7106 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9f246d9674a7f30a9ef72d390260053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d78bcfef84937322e6d5510c1a728848 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_38a1046e0c2f87ac2226e87e15797e02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c83522b25f5b9bc82e2799519437f28e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9e81926b9edc5a2b9ed8aedfb1afabc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd06e5cfc3d4ea73b4b554a6b855532e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc0585219a7efc00ef779d09a198e7c4 |
| publicationDate | 2011-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-075868-A1 |
| titleOfInvention | 2-ACETAMIDO-5-ARIL-1,2,4-SUBSTITUTED TRIAZOLONS AND ITS USE |
| abstract | This refers to procedures for its preparation, its use alone or in combinations for the treatment and / or prevention of diseases, as well as its use for the preparation of medicaments for the treatment and / or prevention of diseases, in Particular for the treatment and / or prevention of cardiovascular diseases. Claim 1: Compound of the formula (1) wherein A represents -C (R6AR6B) - * or -C (R6AR6B) -C (R7AR7B) - *, where * represents the binding site to R3, R6A represents hydrogen, C1-4 alkyl or trifluoromethyl; R6B represents hydrogen or C1-4 alkyl; R7A represents hydrogen, C1-4 alkyl or trifluoromethyl; R7B represents hydrogen or C1-4 alkyl; Q represents CH or N; R1 represents C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-7 cycloalkyl, C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl may be substituted with 1 to .3 independently selected substituents from each other of the group deuterium, halogen, cyano, oxo, hydroxyl, trifluoromethyl, C3-7 cycloalkyl, C1-6 alkoxy, trifluoromethoxy and phenyl, the C3-7 cycloalkyl may be substituted with 1 or 2 substituents independently selected from each other. C1-4 alkyl group, oxo, hydroxy, C1-4 alkoxy and amino, and C1-6 alkoxy may be substituted with 1 or 2 substituents independently selected from each other from the amino group, hydroxyl, C1-4 alkoxy, hydroxycarbonyl and alkoxycarbonyl C1-4 and the phenyl may be substituted with 1 to 3 substituents independently selected from each other from the halogen, cyano, nitro, C1-4 alkyl, trifluoromethyl, hydroxyl, hydroxymethyl, C1-4 alkoxy, trifluoromethoxy, C1-4 alkoxy group methyl, hydroxycarbonyl, C1-4alkoxycarbonyl, aminocarbonyl, C1-4alkylcarbonyl monoalkyl and C1-4alkylcarbonyl, and the C3-7 cycloalkyl may be substituted with 1 or 2 substituents independently selected from each other from the fluorine group, C1-4alkyl , C1-4 alkoxy, hydroxy, amino and oxo, R2 represents benzothienyl, phenyl, thienyl or furyl, benzothienyl, phenyl, thienyl and furyl may be substituted with 1 to 3 substituents independently selected from each other from the halogen group, cyano, nitro, C1-4 alkyl, trifluoromethyl, hydroxy, C1-4 alkoxy and trifluoromethoxy, R3 represents trifluoromethyl, hydroxyl, trifluoromethoxy, C1-4 alkoxy, C3-7 cycloalkoxy, nitro, amino, NR8-C (= O) - R9, -NR10-SO2-R11, -SO2-NR12R13, -OC (= O) -NR14R15, -NR16-C (= O) NR17R18, -NR19-C (= O) -OR20; -S (= O) R21, -O-SO2-NR24R25, -NR26-SO2-NR27R28 or -NR30R31 where R8 represents hydrogen or C1-4 alkyl, R9 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl or R8 and R9 together with the atoms to which they are attached, form a 5-7 membered heterocycle, the 5-7 membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the fluorine group, C1-4alkyl and trifluoromethyl, R10 represents hydrogen or C1-4 alkyl, R11 represents C1-4 alkyl or C3-7 cycloalkyl; or R10 and R11 together with the atoms to which they are attached, form a 5-7 membered heterocycle, the 5-7 membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the fluor group, C1- alkyl 4 and trifluoromethyl, R12 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl; R13 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl; or R12 and R13 together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocycle, the 4- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the fluorine group, oxo, hydroxyl, C1-4 alkyl and trifluoromethyl, R14 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R15 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, or R14 and R15 together with the nitrogen atom to which they are together, they form a 4- to 7-membered heterocycle, the 4- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the group fluorine, oxo, hydroxyl, C1-4 alkyl and trifluoromethyl, R16 represents hydrogen or alkyl C1-4, R17 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R18 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, or R16 and R17 together with the nitrogen atoms to which they are attached, form a heterocycle 5 to 7 members, the 5- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the group fluorine, trifluoromethyl and C1-4 alkyl, or R17 and R18 together with the nitrogen atom to which they are together, they form a heterocycle of 4 to 7 members. the 4- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the group fluorine, oxo, hydroxyl, C1-4 alkyl and trifluoromethyl, R19 represents hydrogen or C1-4 alkyl, R20 represents C1-4 alkyl or C3-7, R19 and R20 cycloalkyl together with the atoms to which they are attached, form a 5- to 7-membered heterocycle, the 5- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the fluorine group. , C1-4 alkyl and trifluoromethyl, n represents the number 0, 1 or 2, R21 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R24 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R25 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, or R24 and R25 together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocycle, the 4- to 7-membered heterocycle may be substituted with 1 or 2 substituents selected independence entirely from each other of the group fluorine, oxo, hydroxyl, C1-4 alkyl and trifluoromethyl, R26 represents hydrogen or C1-4 alkyl; R27 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R28 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, or R26 and R27 together with the nitrogen atoms to which they are attached, form a heterocycle of 5 to 7 members, the 5- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the group fluorine, trifluoromethyl and C1-4 alkyl, or R27 and R28 together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocycle, the 4- to 7-membered heterocycle may be substituted with 1 or 2 substituents independently selected from each other from the group fluorine, oxo, hydroxyl and C1-4 alkyl, R30 represents hydrogen, C1-4 alkyl or C3-7 cycloalkyl, R31 represents C1-4 alkyl or C3-7 cycloalkyl, or R30 and R31 together with the nitrogen atom to which they are attached, form a 4- to 7-membered heterocycle, the 4-7 heterocycle may be substituted members with 1 or 2 substituents independently selected from each other from the group fluorine, oxo, hydroxyl, C1-4alkyl and trifluoromethyl, R4 represents phenyl, naphthyl or a 5-10 membered heteroaryl, the phenyl, naphthyl and the 5-heteroaryl being substituted 10 members with 1 to 3 substituents independently selected from each other from the group halogen, cyano, nitro, C1-4 alkyl, difluoromethyl, trifluoromethyl, hydroxyl, C1-4 alkoxy, difluoromethoxy and trifluoromethoxy, R5 represents hydrogen, deuterium, trifluoromethyl or alkyl C1-4, R29 represents hydrogen or C1-4 alkyl, and its salts, solvates and solvates of the salts. |
| priorityDate | 2009-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 66.