http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-075436-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-08 |
| filingDate | 2010-02-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-075436-A1 |
| titleOfInvention | PRODUCTION AND PURIFICATION OF 1- [2- (2,4-DIMETILFENILSULFANIL) PHENYLE] PIPERAZINE |
| abstract | Claim 1: A process for the production of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine or its salt acceptable for pharmaceutical use comprising the step of obtaining a solution by dissolving the salt 1- [2- (2 , 4-dimethylphenylsulfanyl) phenyl] piperazine-HBr in a solvent comprising more than 65% (v / v) of isopropanol. Claim 15: The process according to claim 1 comprising the step of a) obtaining a solution by dissolving 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr in a solvent comprising more than 65% ( v / v) isopropanol; b) precipitating isopropanol solvate of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr from said obtained solution; c) dissolving 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr isopropanol solvate in a solvent that does not form solvates; and d) precipitate 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr from the solution obtained in c). Claim 19: A process for removing or reducing an impurity of the solid 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr salt or a solution of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr, the process comprising the steps of: a) mixing a solvent comprising more than 65% (v / v) of isopropanol with 1-2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr or with a solution of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr to obtain a solution of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr; and b) cooling said solution obtained to precipitate isopropanol solvate of 1- (2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr isopropanol solvate; c) dissolve isopropanol solvate of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl ] piperazine-HBr, in a solvent that does not form solvates; and d) precipitate 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr from the solution obtained in step c). Claim 22: A compound that is isopropanol solvate of 1- [2- (2,4-dimethylphenylsulfanyl) phenyl] piperazine-HBr. |
| priorityDate | 2009-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.