http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-075425-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-135 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-29 |
| filingDate | 2010-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0164bf19cc9c1ebd72e480b31e8f28c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5070e80287448225d580f3b31bd47b65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5435ba0c12a17a6367072ecf67a73c2d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5d5831d3d5fcbc940bb83a9f698dcfb |
| publicationDate | 2011-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-075425-A1 |
| titleOfInvention | PREPARATION AND INTERMEDIARY PROCEDURE |
| abstract | Claim 1: Process for the preparation of compounds of the general formula (1), in which they mean: m the figure 1 or 2; n the figure 0, 1 or 2; R1 C1-3- alkyl or C3-6 cycloalkyl, and R2 H or C1-3 alkyl, their enantiomers, their diastereoisomers, mixtures and salts thereof, in particular their physiologically tolerable salts with organic or inorganic acids or bases, characterized in that it comprises the steps: (a) the reaction of 3,5-dimethylannisol with chlorosulfonic acid; (b) the reaction of the 4-methoxy-2,6-dimethylsulfonium chloride obtained in step (a), with a compound of the general formula: HO-CH2-CH2-NH-R2 in which R2 is defined as It has been indicated above; (c) the reaction of a compound of the general formula (2) obtained in step (b) in which R2 is defined as indicated above, with a compound of the general formula: XO-C (= O) -CH2-Y in which X means a hydrogen atom, an alkali metal, for example lithium, sodium or potassium, or a C1-4 alkyl group, but preferably sodium, and Y means a halogen atom, for example chlorine or bromine, preferably chlorine; (d) optionally, recrystallization in a solvent of a compound of the general formula (3), obtained in step (c) in which R2 is defined as indicated above and X represents a hydrogen atom, an alkali metal , for example lithium, sodium or potassium, or a C1-4 alkyl group, but preferably sodium; (e) the coupling of a compound of the general formula (3), obtained in step (c) or (d) in which R2 is defined as indicated above and X represents a hydrogen atom, an alkali metal, for example lithium, sodium or potassium, or a C1-4 alkyl group, but preferably sodium, with a compound of the general formula (4) in which m, n, R1 and R2 are defined as indicated above, I represent one of the figures 0, 1, 2 or 3, preferably 3; and (f) the isolation of a compound of the general formula (1) obtained in step (d). Claim 3: Compounds characterized in that they have the general formula (3) in which they mean R2 H or C1-3 alkyl, and X hydrogen, lithium, sodium, potassium or a C1-4 alkyl group, preferably sodium. |
| priorityDate | 2009-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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