http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-075383-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025 |
| filingDate | 2010-02-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ae8a3c387a6bee9e7511d0011312f114 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04fbeb5209c87649b889e1020c794317 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e61c37a82585181c52048bd0818d6fbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f91f67a5b1e84ab878c907f57e60cc69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b572d629ed2fcf003540e0a2bc59cee |
| publicationDate | 2011-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-075383-A1 |
| titleOfInvention | DERIVATIVES OF TRIAZOLO [4,3-B] PIRIDAZINA |
| abstract | It refers to processes for the preparation of said compounds, pharmaceutical compositions containing them and their use in the treatment of conditions associated with the androgen receptor, in particular prostate cancer. Claim 1: A compound characterized in that it is of Formula 1, or a pharmaceutically acceptable salt thereof: wherein R1 represents C1-4 haloalkyl; k represents 0, 1 or 2: n and p independently represent 1 or 2: Y represents N, C, CH or COH; the dotted line represents a simple link when Y is N, CH or COH; the dotted line represents a double bond when Y is C, L1 is a direct bond and J is indolyl pyrrolopyridinyl: L1 represents a direct bond, - (CR3R4) t-, - (CR3R4) vO- (CR3R4) v-, -N (R5) - (CH2) q-, -S-, -S (O) - or S (O) 2-; R3 and R4, identically or differently in each occurrence, represent hydrogen or methyl; R5 represents hydrogen or methyl: q, identically or differently in each occurrence, represents 0, 1, 2, 3 or 4; t represents 1, 2 or 3; v, identically or differently in each occurrence, represents 0, 1 or 2; j represents: aryl; C3-6 cycloalkyl; a monocyclic 4, 5, 6 or 7-membered heterocyclic ring comprising 1, 2 or 3 heteroatoms that are independently selected from O, N or S; A monocyclic 5 or 6 membered heteroaryl ring comprising 1, 2, 3 or 4 heteroatoms that are independently selected from O, N or S; or a 9 or 10-membered bicyclic heteroaryl ring system comprising 1, 2, 3, 4 or 5 heteroatoms that are independently selected from O, N or S; L2 represents a direct link. - (CR3R4) t-, -C (O) N (R5) - (CH2) q-, -C (O) N (R5) - (CH2) q- S (O) 2-, -NR5C (O) - (CH2) q-, -C (O) - (CH2) q-, -O- (CR9R10) q-, -O- (CR3R4) q-NR5- (CH2) q-, -O- (CR3R4) qC (O) NR5- (CH2) q-, -S-, -S (O) - or -S (O) 2-; R9 and R10, identically or differently in each occurrence, represent hydrogen, methyl, ethyl, isopropyl, cyclopropyl or methoxymethyl: R2 represents: halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, carboxy, C1 alkoxy -6, cyano, oxo, C 1-6 fluoroalkyl, hydroxy, mood, N-C 1-4 alkyl or N, N-di-C 1-4 alkyl; aryl, wherein the aryl ring is optionally substituted by 1, 2 or 3 substituents that are selected from R6; a monocyclic 4, 5, 6 or 7 heterocyclic ring comprising 1, 2 or 3 heteroatoms that are independently selected from O, N or S and wherein the heterocyclic ring is optionally substituted by 1, 2 or 3 substituents that are selected of R6; a monocyclic 5- or 6-membered heteroaryl ring comprising 1, 2, 3 or 4 heteroatoms that are independently selected from O, N or S and wherein the heteroaryl ring is optionally substituted by 1, 2 or 3 substituents that are selected from R6 : or a 9 or 10-membered bicyclic heteroaryl ring system comprising 1, 2, 3, 4 or 5 heteroatoms that are independently selected from O, N or S and wherein the heterocyclic ring is optionally substituted by 1, 2 or 3 substituents that are selected from R6; R 6 represents amino, halo, C 1-6 alkyl, C 3-6 cycloalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 1-6 alkoxy, C 2-6 alkanoyl, C 1-6 alkoxy, C 1-6 alkyl, carboxy, cyano, oxo , C1-6 fluoroalkyl, hydroxy, C1-6 hydroxyalkyl, C1-6 alkyl sulfanyl, C1-6 alkyl sulfinyl, C1-6 alkyl sulfonyl, oxetan-3-ylcarbonyl, N-C1-4 alkyl N, N-di- C 1-4 alkyl amino or -C (O) NR7R8 wherein R7 and R8 independently represent hydrogen or methyl; and r represents 0, 1, 2 or 3. |
| priorityDate | 2009-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.