http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-074506-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_40765ca9a78b54a8a76f781d159ad145 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-708 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-212 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-683 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-527 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-12 |
| filingDate | 2009-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-074506-A1 |
| titleOfInvention | TOLL TYPE RECEIVERS MODULATORS |
| abstract | Its pharmaceutically acceptable salts, compositions containing compounds, and therapeutic methods that include the administration of said compounds. Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt or ester thereof, in which: YZ is -CR4R5-, -CR4R5-CR4R5-, -C (O) CR4R5-, -CR4R5C (O) -, -NR8C (O) -, -C (O) NR8-, -CR4R5S (O) 2-, or -CR5 = CR5-; L1 is -NR8-, -O-, -S-, -N (R8) C (O) -, -S (O) 2-, -S (O) -, -C (O) N (R8) - , -N (R8) S (O) 2-, -S (O) 2N (R8) - or a covalent bond; R 1 is alkyl, substituted alkyl, haloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, carbocyclylalkyl substituted, heterocyclyl, heterocyclylalkyl, substituted heterocyclyl, substituted alkyl heteroarylalkyl, substituted heteroarylalkyl, carbocyclylheteroalkyl, substituted carbocyclylheteroalkyl, heterocyclyl heteroalkyl, heterocyclyl heteroalkyl substituted, aryl heteroalkyl, aryl heteroalkyl substituted, heteroaryl heteroalkyl, or heteroaryl substituted heteroalkyl; X1 is alkylene, substituted alkylene, hetero alkylene, substituted hetero alkylene, alkenylene, substituted alkenylene, alkynylene, substituted alkynylene, carbocyclylene, substituted carbocyclylene, heterocyclylene, substituted heterocyclylene, -NR8-, -O-, -C (O) -, - S (O) -, -S (O) 2-, or a link; D is carbocyclyl, substituted carbocyclyl, heterocyclyl or substituted heterocyclyl, wherein said carbocyclyl, substituted carbocyclyl, heterocyclyl or substituted heterocyclyl, is substituted with one or two -L2-NR6R7; or D is heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl in which said heterocyclyl, substituted heterocyclyl, heteroaryl or substituted heteroaryl comprises 1 to 4 N atoms; each L2 is independently alkylene, substituted alkylene, hetero alkylene, substituted hetero alkylene, or a covalent bond; each R3 is independently halogen, cyano, azido, nitro, alkyl, substituted alkyl, hydroxy, amino, heteroalkyl, substituted heteroalkyl, alkoxy, haloalkyl, haloalkoxy, -CH, -C (O) OR8, -S (O) R8 , -S (O) 2R8, -C (O) NR9R10, -N (R9) C (O) R8, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, -S (O ) 2NR9R10, -N (R9) S (O) 2R8, -N (R9) S (O) 2OR10, -OS (O) 2NR9R10; n is 0, 1, 2, 3, 4 or 5; R4 and R5 are each independently H, alkyl, substituted alkyl, haloalkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, heterocyclyl substituted, heterocyclylalkyl, arylalkyl, substituted heterocyclyl, substituted heterocyclyl substituted heteroarylalkyl, carbocyclylheteroalkyl, substituted carbocyclylheteroalkyl, heterocyclyl heteroalkyl, substituted heterocyclyl heteroalkyl, aryl heteroalkyl, substituted aryl heteroalkyl, heteroaryl heteroalkyl, or substituted heteroaryl heteroalkyl, cyano, C-O (C), C-O, C8-O (C), C-O, C-O (C), C-O, C-O, C-8, C-O (C), C-C, O (C), C-O, C-O, C-8 S (O) R8, -S (O) 2R8, -C (O) OR8, or -C (O) NR9R10; or R4 and R5, taken together with the carbon to which both are attached, form a carbocycle, substituted carbocycle, heterocycle or substituted heterocycle; or R4 and R5, when they are on the same carbon atom, taken together with the carbon to which they are attached are -C (O) - or -C (NR8) -; or two R4 or two R5 in adjacent carbon atoms when taken together with the carbons to which they are attached form a 3- to 6-membered carbocycle, substituted carbocycle, heterocycle or substituted heterocycle; R6 and R7 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, haloalkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclyl, heterocyclyl, heterocyclyl, heterocyclyl, heterocyclyl, heterocyclyl, heterocyclyl substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylheteroalkyl, carbocyclylheteroalkyl substituted, heterocyclyl heteroalkyl, heterocyclyl heteroalkyl substituted, aryl heteroalkyl, hetero heteroalkyl, hetero substituted alkyl heteroalkyl, substituted aryl heteroalkyl, substituted aryl O) R8, -S (O) R8, -S (O) 2R8, -C (O) OR8, or -C (O) NR9R10, -S (O) 2NR9R10; or R6 and R7, taken together with the nitrogen to which both are attached, form a substituted or unsubstituted heterocycle, which may contain one or more additional heteroatoms selected from N, O, P, or S; or R7 taken together with L2, and the N to which both are attached, forms a substituted or unsubstituted 3- to 8-membered heterocycle that may contain one or more additional heteroatoms selected from N, O, S, or P; R8 is H, alkyl, substituted alkyl, haloalkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, substituted heterocyclyl, aryl substituted alkyl , heteroarylalkyl, substituted heteroarylalkyl, carbocyclylheteroalkyl, substituted carbocyclylheteroalkyl, heterocyclyl heteroalkyl, heterocyclyl heteroalkyl substituted, aryl heteroalkyl, aryl heteroalkyl substituted, heteroaryl heteroalkyl, or substituted heteroaryl; and R9 and R10 are each independently H, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, haloalkyl, heteroalkyl, substituted heteroalkyl, carbocyclyl, substituted carbocyclyl, carbocyclylalkyl, substituted carbocyclylalkyl, heterocyclyl, heterocyclyl, heterocyclyl , substituted heterocyclylalkyl, arylalkyl, substituted arylalkyl, heteroarylalkyl, substituted heteroarylalkyl, carbocyclylheteroalkyl, carbocyclylheteroalkyl substituted, heterocyclyl heteroalkyl, heterocyclyl heteroalkyl, substituted aryl heteroalkyl heteroalkyl heteroalkyl substituted heteroarylalkyl; or R9 and R10, taken together with the nitrogen to which both are attached form a substituted or unsubstituted heterocycle; in which each substituted alkyl, substituted alkenyl, substituted alkynyl, substituted heteroalkyl, substituted carbocyclyl, substituted carbocyclylalkyl, substituted heterocyclyl, substituted heterocyclylalkyl, substituted arylalkyl, substituted heteroarylalkyl, substituted heterocyclyl alkyl, heteroalkyl substituted heteroalkyl heteroalkyl heteroalkyl, substituted heteroalkyl substituted, hetero substituted alkylene, substituted alkenylene, substituted alkynylene, substituted carbocyclylene, or substituted heterocyclylene is independently substituted with one to four substituents selected from the group consisting of -halogen, -R, -O-, = O, -OR. -SR, -S-, -NR2, -N (+) R3, = NR, -C (halogen) 3, -CR (halogen) 2, -CR2 (halogen), -CN, -OCN, -SCN, - N = C = O, -NCS, -NO, -NO2, = N2, -N3, -NRC (= O) R, -NRC (= O) OR, -NRC (= O) NRR, -C (= O ) NRR, -C (= O) OR, -OC (= O) NRR, -OC (= O) OR, -C (= O) R, -S (= O) 2OR, -S (= O) 2R , -OS (= O) 2OR, -S (= O) 2NR, -S (= O) R, -NRS (= O) 2R, -NRS (= O) 2NRR. -NRS (= O) 2OR, -OP (= O) (OR) 2, -P (= O) (OR) 2, -P (O) (OR) (O) R, -C (= O) R , -C (= S) R, -C (= O) OR, -C (= S) OR, -C (= O) SR, -C (= S) SR, -C (= O) NRR, - C (= S) NRR, -C (= NR) NRR, and -NRC (= NR) NRR; in which each R is independently H, alkyl, cycloalkyl, aryl, arylalkyl, or heterocyclyl. |
| priorityDate | 2008-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 52.