http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-074159-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b5d62b24bd9ee041f521ff3177003b86 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-155 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C279-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| filingDate | 2009-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8b25b76d3243afb94fdb09a01edddd5 |
| publicationDate | 2010-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-074159-A1 |
| titleOfInvention | A METFORMIN GLYCINATE SALT FOR THE CONTROL OF GLUCOSE IN BLOOD, PROCESS FOR OBTAINING AND USE |
| abstract | This refers to the synthesis of a 1,1-dimethylbiguanid glycinate salt, called Metformin glycinate designed for the control of blood glucose. These salts exhibit advantages over other metformin salts. These advantages refer, first of all, to the fact that the counterion exhibits hypoglycemic effects on their own, the hypoglycemic effect is more pronounced. In addition, this salt exhibits a better absorption, reaching a higher plasma concentration than that produced with metformin hydrochloride. The synthesis was carried out from metformin hydrochloride releasing the hydrochloride counterion, using an ion exchange column, the released metformin was dissolved in aqueous medium and subsequently glycine was added at room temperature and constant stirring, the resulting product was heated producing In a concentrated solution of the product, an organic solvent is added to create insolubility and promote crystallization in a saturated medium, the excess glycine precipitates and the metformin glycinate salt is obtained after filtering and concentrating said salt. Metformin glycinate salt has a more pronounced pharmacological effect in reducing blood glucose levels. Claim 6: A process for obtaining the metformin and glycinate salt characterized by comprising the following steps: a solution of the metformin hydrochloride salt is passed through an ion exchange column to obtain free metformin by separating the hydrochloride counterion; the released metformin is dissolved in aqueous medium and glycine is added at room temperature while stirring continuously; The resulting mixture is concentrated and a solvent is added where the glycine is insoluble, until the excess of this precipitates; it is filtered to remove excess glycine and the result is evaporated until a second precipitate is achieved; and the second precipitate is washed and purified. Claim 7: The use of the salt of claim 1 to treat hyperglycemia in warm-blooded animals characterized in that it consists of administering various doses of metformin glycinate by various routes: intravenous injection, intramuscular, nasal, intraperitoneal, sublingual injection, etc. , but preferably oral to achieve a decrease in blood glucose levels. |
| priorityDate | 2008-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.