http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-073665-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-3515 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-315 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 |
| filingDate | 2009-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-11-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-073665-A1 |
| titleOfInvention | DSARN FOR THE TREATMENT OF RNA INFECTION OF POSITIVE CHAINS, SUCH AS THE HEPATITIS C (HCV) VIRUS |
| abstract | The application refers to double-stranded ribonucleic acids (dsRNAs) that target the expression of the carbamoylphosphate 2 synthetase gene, aspartate transcarbamylase, and dihydro-orotase (CAD), and their use for the treatment of virus infections. RNA from positive chains, such as hepatitis C virus (HCV). Each dsRNA comprises an anti-sense chain that has a nucleotide sequence that is less than 30 nucleotides in length, generally 19 to 25 nucleotides in length, and that is substantially complementary to at least a part of the target mRNA of CAD. A plurality of these dsRNAs can be used to provide a therapeutic benefit. The application also refers to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier, and which includes a delivery modality, such as fully encapsulated liposomes or lipid complexes. The application also includes methods for the treatment of diseases caused by infection with the positive chain RNA virus using the pharmaceutical compositions: and methods for inhibiting the spread of positive chain RNA viruses within and between cells. |
| priorityDate | 2008-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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