http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-073369-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| filingDate | 2009-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-073369-A1 |
| titleOfInvention | DERIVATIVES OF 2-CARBOXAMIDA-CICLOAMINO-UREA AS PI-3 INHIBITORS |
| abstract | Compositions, use of the compounds in the treatment of diseases that are improved by the inhibition of phosphatidyl-inositol-3 kinase, and preparation processes. Claim 1: A compound of the formula (1) or a salt thereof, wherein A represents a heteroaryl selected from the group consisting of formulas (2), R1 represents one of the following substituents (1) C1-7 alkyl unsubstituted or substituted, preferably substituted, wherein these substituents are independently selected from one or more, preferably one to nine of the following fractions: deuterium, F, or one to two of the following fractions: C3 cycloalkyl- 5; (2) optionally substituted C3-5 cycloalkyl, wherein these substituents are independently selected from one or more, preferably one to four of the following fractions: deuterium, C1-4 alkyl (preferably methyl), F, cyano , aminocarbonyl; (3) optionally substituted phenyl, wherein these substituents are independently selected from one or more, preferably one to two of the following fractions: deuterium, halogen, cyano, C1-7 alkyl, C1-7-amino alkyl, di-C1-7-amino alkyl, C1-7-amino-carbonyl alkyl, di-C1-7-amino-carbonyl alkyl, C1-7 alkoxy; (4) optionally mono- or di-substituted amine; wherein these substituents are independently selected from the following fractions: deuterium, C1-7 alkyl (which is unsubstituted or substituted by one or more substituents selected from the group deuterium, F, Cl, hydroxyl), phenyl sulfonyl (which it is unsubstituted or substituted by one or more, preferably a C1-7 alkyl, C1-7 alkoxy, di- C1-7 alkyl-amino- C1-7 alkoxy; (5) substituted sulfonyl, wherein this substituent is selected from of the following fractions: C1-7 alkyl (which is unsubstituted or substituted by one or more substituents selected from the deuterium group, F), pyrrolidino (which is unsubstituted or substituted by one or more substituents selected from the deuterium group , hydroxyl, oxo, in particular an oxo); (6) F, Cl; R2 represents H; R3 represents (1) H, (2) F, Cl, (3) optionally substituted methyl, wherein these substituents are independently selected from one or more of preference ia one to three of the following fractions: deuterium, F, Cl, dimethyl amino; with the exception of (S) -1 - ({5- [2- (terbutyl) -pyrimidin-4-yl] -4-methyl-thiazol-2-yl} -amide) of 2-amide of pyrrolidin- 1,2-dicarboxylic. |
| priorityDate | 2008-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 59.