http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-073116-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3b70512b2076a2759fccaecf9fe962d5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 |
| filingDate | 2009-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-073116-A1 |
| titleOfInvention | PIRROLO COMPOUNDS [2,3-D] -PIRIMIDINE MODULATORS OF CDK PROTEINQUINASES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE TREATMENT AND / OR PREVENTION OF CANCER AND AUTOIMMUNE DISEASES. |
| abstract | Claim 1: A compound of the formula (1), or a pharmaceutically acceptable salt, wherein: X is CR9 or N; R1 is C1-8 alkyl, CN, C (O) OR4 or CONR5R6, a 5-14 membered heteroaryl group, or a 3-14 membered heteroalkyl cyclo group; R2 is C1-8 alkyl, C3-14 cycloalkyl, or a 5-14 membered heteroaryl group, and wherein R2 may be substituted with one or more C1-8 alkyl, or OH; L is a bond, C1-8 alkylene, C (O), or C (O) NR10, and wherein L may be substituted or unsubstituted; Y is H, R11, NR12R13, OH, or Y is part of the group of the formula (2) where Y is CR9 or N; wherein 0 to 3 R8 may be present, and R8 is C1-8 alkyl, oxo, halogen, or two or more R8 can form a bridged alkyl group; W is CR9 or N; R3 is H, C1-8 alkyl, C1-8-R14 alkyl, C3-14 cycloalkyl, C (O) -C1-8 alkyl, halo- C1-8 alkyl, C1-8-OH alkyl, C (O) NR14R15 , cyano-C1-8 alkyl, C (O) R14, C0-8-C (O) alkyl-C0-8-NR14R15 alkyl, C0-8-C (O) alkyl OR14, NR14R15, SO2-C1-8 alkyl , C1-8 alkyl-C3-14 cycloalkyl, C (O) -C1-8 alkyl-C3-14 cycloalkyl, C1-8 alkoxy, or OH, which may be substituted or unsubstituted when R3 is not H; R9 is H or halogen; R4, R5, R6, R7, R10, R11, R12, R13, R14 and R15 are each independently selected from H, C1-8 alkyl, C3-14 cycloalkyl, a 3-14 membered cyclo-heteroalkyl group, a C6-14 aryl group, a 5-14 membered heteroaryl group, alkoxy, C (O) H, C (N) OH, C (N) OCH3, C (O) -C1-3 alkyl, C1-8 alkyl -NH2, C1-6-OH alkyl, and wherein R4, R5, R6, R7, R10, R11, R12, R13, R14, and R15 when they are not H, may be substituted or unsubstituted; m and n are independently from 0 to 2; and wherein L, R3, R4, R5, R6, R7, R10, R11, R12 and R13, R14 and R15 may be substituted with one or more of C1-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, cycloalkyl C3-14, 5-14 membered heteroaryl group, C6-14 aryl group, a 3-14 membered cyclo-heteroalkyl group, OH, (O), CN, alkoxy, halogen or NH2. Claim 21: A compound of the formula (3) or a pharmaceutically acceptable salt thereof, wherein: R50 is CONR54R55 or CN; R51 is C3-14 cycloalkyl which may be unsubstituted or substituted by C1-3alkyl, or OH; Z is CH or N; and V is NR56 or CHR57; R54 and R55 are independently H, or C1-3 alkyl; R52, R53, R56 and R57 are independently H, C1-8 alkyl, C3-14 cycloalkyl, halo- C1-8 alkyl, NR58R59, C (O) OR60, C (O) -C1-8 alkyl, C0-8 alkyl - (O) -C0-8-NR61R62 alkyl, C1-8 alkoxy, C1-8-R63 alkyl, C (O)-5-14 membered cyclo-heteroalkyl group, C3-14 cycloalkyl group, each of which , when it is not H, it may be substituted by one or more of C1-8 alkyl, OH or CN; R58, R59, R60, R61, R62 and R63 are H or C1-8 alkyl. |
| priorityDate | 2008-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.