http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-072936-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28e3113097dd6d28720572e47f2f2407 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| filingDate | 2009-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d687c6abca301c322a1de6bde269f17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e991e9fe4083df9f9ef5b6c222c37a54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c758aad5cf58ef5654a13774f958446 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f520c0a0702a9c733b35a6ce3dce5df6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4deb790416ea8c30d6abdab81b5ea409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_641d91f94b9f931e523f64b6a4054439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_50cb13d71388091912fb43a8b15965a8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24b39db5d695b239a50ea94a5781b6f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cc3647b095cf023a664a10dbd7577a66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60b432e63723ac9ab4d3c0f487f15404 |
| publicationDate | 2010-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-072936-A1 |
| titleOfInvention | PIRIDAZIN AND PIRIMIDIN DERIVATIVES CONDENSED WITH NITROGEN HETEROCICLES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME AS ANTICANCER AGENTS. |
| abstract | Claim 1: A compound having the formula (1) or a pharmaceutically acceptable salt thereof, wherein G is selected from the group consisting of CR4 and N; J is selected from the group consisting of CR5 and N; K is selected from the group consisting of CR6 and N; M is selected from the group consisting of CR7 and N; L is absent or a linker that provides 1, 2, 3, 4, 5 or 6 separation of atoms between the rings to which L binds, where the atoms of the linker that provides the separation are selected from the group consisting of carbon , oxygen, nitrogen and sulfur; T is selected from the group consisting of CR8 and N; U is selected from the group consisting of CR9 and N; V is selected from the group consisting of CR10 and N; W is selected from the group consisting of CR11 and N; X is selected from the group consisting of CR12 and N; And it is selected from the group consisting of CR13 and N; Z is selected from the group consisting of CR14R15 and NR16; R1 is selected from the group consisting of hydrogen, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, C1-10 alkylcarbonyl, C3-12 cycloalkyl C1-5 carbonyl, C3-12 heterocycloalkylcarbonyl C1-10, C1-10 arylcarbonyl, C1-10 heteroaryl C1-5 carbonyl, C9-12 bicycloaryl C1-5 carbonyl, C8-12 heterobicycloaryl C1-5 carbonyl, amino, C1-10 alkyl amino, sulfonamido, imino, sulfonyl, sulfinyl, alkyl C1-10, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl C1-10, sulfinylalkyl C1-10, azaalkyl C1-10, oxaalkyl C1-10, oxoalkyl C1-10, iminoalkyl C1-10, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10alkyl, C1-10 arylalkyl, C1-10 heteroaryl C1-5alkyl, C9-12 cycloaryl C1-5alkyl, C8-12 heterobicycloarkyl C1-5alkyl, heteroalkyl C1-10, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, heteroaryl C4-10, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted, or R1 has the formula -C (= O) -R19; R2 is hydrogen or a substituent convertible in vivo to hydrogen; R3 is selected from the group consisting of hydrogen, carbonyloxy. C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1-10 alkyl, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl , C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl C1-10, sulfinylalkyl C1-10, azaalkyl C1-10, oxaalkyl C1-10, oxoalkyl C1-10, iminoalkyl C1-10, cycloalkyl C3-12alkyl C1-5, heterocycloalkyl C3-12 C1-10 alkyl, C1-10 arylalkyl, C1-10 heteroaryl C1-5 alkyl, C9-12 bicycloaryl C1-5 alkyl, C8-12 heterobicycloaryl C1-5 alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl , C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted, or R3 is absent when the nitrogen to which it is attached forms part of a double bond; R4 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R5 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R6 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R7 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R8 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R9 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-12 carbonylaryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R10 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3-12 cycloalkyl C1-5 alkyl, heterocycloalkyl C3-12 C1-10 alkyl, arylalkyl C1-10, heteroaryl C1-10alkyl C1-5, bicycloaryl C9-12alkyl C1- 5, C8-12 heterobicycloaryl C1-5alkyl, C1-10 heteroalkyl, C3-12 cycloalkyl, C3-12 heterocycloalkyl, C9-12 bicycloalkyl, C3-12 heterobicycloalkyl, C4-12 aryl, C4-12 carbonylaryl, C4-10 heteroaryl, C9-12 bicycloaryl and C4-12 heterobicycloaryl, each substituted or unsubstituted; R11 is selected from the group consisting of hydrogen, halo, nitro, cyano, thio, oxy, hydroxy, carbonyloxy, C1-10 alkoxy, C4-12 aryloxy, C1-10 heteroaryloxy, carbonyl, oxycarbonyl, aminocarbonyl, amino, C1- alkyl 10amino, sulfonamido, imino, sulfonyl, sulfinyl, C1-10 alkyl, C1-10 haloalkyl, C1-10 hydroxyalkyl, C1-10 carbonylalkyl, C1-10 thiocarbonylalkyl, C1-10 sulfonylalkyl, C1-10 sulfinylalkyl, C1-10 azaalkyl, C1-10 oxaalkyl, C1-10 oxoalkyl, C1-10 iminoalkyl, C3 cycloalkyl |
| priorityDate | 2008-08-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 46.