http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-072622-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eccd894c99fea2d1c0c8735872bb2309 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-04 |
| filingDate | 2009-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2025c2f7aba118c3b0c1cfaabb4398b6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03798399ef15c00228e2826c00ae8f64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5ead94a5b2dce653c2b6502dd6d93e2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d755463cdeb7a4ba3d9f9d402388ae26 |
| publicationDate | 2010-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-072622-A1 |
| titleOfInvention | IMIDAZO DERIVATIVES [2,1-B] [1,3,4] TIADIAZOL, PHARMACEUTICAL COMPOSITIONS THAT INCLUDE THEM, METHOD TO PREPARE THEM, AND USE OF THEM FOR THE TREATMENT OF TUMORS AND OTHER DISEASES INDICATED BY KINASES |
| abstract | Imidazo [2,1-b] [1,3,4] thiadiazole derivatives of the formula (1) wherein R 1 is unsubstituted mono- or bicyclic carboaryl or unsubstituted mono- or bicyclic heteroaryl having 1 to 4 atoms of N, O and / or S, each of which may be substituted with at least one substituent selected from the group of A, Hal, -CN, - (CH2) nOR3, -CO-R3, -CO-NR3R3, -CO -N (R3) 2, - (CH2) nNR3R3, - (CH2) nN (R3) 2 and -SO2N (R3) 2; R2 is A 'or Cyc; R3 denotes, independently of each other, in R1, A 'and Cyc: H, A, -OH, -OA, optionally substituted acyl or carboaryl; Denote, independently of each other, in R1 and R3: unbranched or branched alkyl having 1-10 C atoms, wherein one or two non-adjacent CH2 groups may be replaced by N and / or NH, and / or in addition, 1-7 H atoms may be replaced by Hal, -OH, morpholine and / or amino; and A 'denotes unbranched or branched alkyl having 1-10 C atoms, wherein 1-7 H atoms can be replaced by Cyc, -OR3, -NR3R3, -N (R3) 2, Het1 and optionally substituted carboaryl ; Het1 denotes, independently of each other, in R1 and A ': saturated, unsaturated or aomatic mono- or bicyclic heterocycle having 1 to 4 atoms of N, O and / or S, optionally substituted with = O; Cyc denotes, independently of one another, in R2, R3 and A ': cycloalkyl having 3-7 C atoms, which may be substituted with -OR3, -NR3R3 or -N (R3) 2; Hal denotes, independently of each other, in R1 and A: F, Cl, Br or I; and n is 0, 1, 2, 3 or 4; and / or its physiologically acceptable salts. They are inhibitors of the TGF-beta I receptor kinase and can be used, inter alia, for the treatment of tumors. |
| priorityDate | 2008-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 42.