http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-072611-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9ce92a4d2fdab0cc5440f710c3787f38 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D207-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| filingDate | 2009-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eadbeaf477dff3f6797d015ebb55c66b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_221b9df465855fb4f0bc0fef64390bf8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3ad6e30ab388956f7ab8262f331f161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_de2e01b3c4c1dc9cf3dca6bb62f957f0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2772e85a780b37eeab1b8c71b6a8d90f |
| publicationDate | 2010-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-072611-A1 |
| titleOfInvention | COMPOUNDS OF 3- (Phenoxyphenylmethyl) PIRROLIDINE, A METHOD FOR THEIR PREPARATION, SYNTHESIS INTERMEDIARY AND ITS OBTAINING PROCESS, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND THEIR USE IN THE MANUFACTURE OF A MEDICINAL PRODUCT FOR THE TREATMENT OF DISEASE MEDIUM 5- HT AND NE. |
| abstract | These compounds are inhibitors of serotonin and norepinephrine reabsorption. In another aspect, they are provided with pharmaceutical compositions comprising said compounds; methods for using said compounds; and process and intermediaries to prepare said compounds. Use of the same in drugs with inhibitory action of 5-HT and NE. Claim 1: A compound of formula 1 characterized in that a is 0 to 5; each R1 is independently selected from halo, -C1-6alkyl, -C2-6alkyl, -O-C1-6alkyl, -C1-4alkylene-O-C1-4alkyl, -C0-1 -alkylene-phenyl, - O-C0-3-alkylene-phenyl, -C0-6-OH alkylene, -CN, -C0-2-COOH alkylene, -CHO, -C (O) -C 1-6 alkyl, -C (O) O-alkyl C1-4, -CH2SH, -S-C1-6 alkyl, -C 1-4 alkyl-S-C1-4 alkyl, -SO2-C1-6 alkyl, -SO2NRaRb, -NHSO2Ra, -C0-1-NRaRb alkylene, -NHC (O) -C 1-6 alkyl, -C (O) NRaRb, and -NO2; R 2 to R 6 are independently selected from H, halo, -C 1-6 alkyl, -C 2-6 alkynyl, -O-C 1-6 alkyl, -C 1-4 alkylene-O-C 1-4 alkyl, -C 0-1 alkylene phenyl, -O-C0-3-alkylene-phenyl, -C0-6-alkylene, -CN, -C0-2-COOH alkylene, -CHO, -C (O) -C 1-6 alkyl, -C (O) O-C1-4 alkyl, -CH2SH, -S-C1-6 alkyl, -C 1-4 alkylene-S-C1-4 alkyl, -SO2-C1-6 alkyl, -SO2NRaRb, -NHSO2Ra, -C0-1 alkylene -NRaRb, -NHC (O) -C 1-6 alkyl, -C (O) NRaRb, and -NO2; Ra and Rb are independently H or -C 1-4 alkyl; each alkyl in R1 to R6 is optionally substituted with 1 to 5 fluorine atoms; and each phenyl in R1 to R6 is optionally substituted with 1 or 2 groups independently selected from halo, -C 1-6 alkyl, and -O-C 1-6 alkyl; or a pharmaceutically acceptable salt thereof. Claim 49: An intermediate useful in the synthesis of the compound according to claim 1 characterized in that it has the formula (8) or (8 ') wherein P represents an amino protecting group. |
| priorityDate | 2008-07-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 35.