http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-072585-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-04 |
| filingDate | 2009-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-072585-A1 |
| titleOfInvention | PIRIDINILOS MODULADORES DE RANGE-SECRETASA |
| abstract | The compounds of Formula 1 are useful for the treatment of diseases associated with gamma-secretase activity including Alzheirner's disease. Claim 1: A compound having the general formula (1) in which A is phenyl, pyridyl, pyrimidyl, pyridacyl, naphthyl, biphenyl, quinolinyl, isoquinolinyl, quinazolinyl, or benzothiazolyl, alternatively, A is taken together with R3, R4 and R5, and is selected from the group consisting of formulas (2); X is a direct link, or -NR2-; wherein R2 is C1-5 alkyl or C1-5 alkenyl, any of which is optionally substituted with cyclohexyl, heterocyclyl, or up to three substituents independently selected from the group consisting of F, CI, Br, I, and CF3; R1 is H, C1-5 alkyl, or C1-5 alkenyl; wherein said alkyl and alkenyl groups are optionally substituted with up to three substituents independently selected from the group consisting of F, CI, Br, I and CF3; R3, and R6 are independently selected from the group consisting of H. F. Cl, Br, I, CN. OH, C (O) N (C1-4 alkyl) 2, S (O) 2 C1-4 alkyl, SO2N (C1-4 alkyl) 2, S (O) N (C1-4 alkyl) 2, N (C1 alkyl -4) S (O) 2 C1-4 alkyl, N (C1-4 alkyl) S (O) C1-4 alkyl, S (O) 2 C1-4 alkyl, N (C1-4 alkyl) S (O) 2N (C1-4 alkyl) 2, C1-4 alkyl, N (C1-4 alkyl) 2, N (C1-4 alkyl) C (O) C1-4 alkyl, N (C1-4 alkyl) C (O) N (C1-4 alkyl) 2, N (C1-4 alkyl) C (O) C1-4alkyl, OC (O) N (C1-4 alkyl) 2, C (O) C1-4 alkyl, C1-4 alkyl substituted and unsubstituted and C1-4 alkoxy substituted and unsubstituted and wherein the substituents of both C1-4 alkyl and C1-4 alkoxy groups are selected from the group consisting of F, CI, Br, I, and CF3; R4, R5, R7, and R8 are independently selected from the group consisting of CF3, OCF3, H, F, CI, C1-4alkyl, C1-4alkyl, -SO2CH3, and CN; R9 is H, C1-5 alkyl, or C1-5 alkenyl; wherein said alkyl and alkenyl groups are optionally substituted with up to three substituents independently selected from the group consisting of F. CI, Br, I and CF3, and solvates, hydrates, esters, and pharmaceutically acceptable salts thereof. |
| priorityDate | 2008-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 23.