http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-070811-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_21cfb7dd79973529725cde19b4f43cba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 |
| filingDate | 2009-03-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c9bd42f84da54c249f1f71092db75be0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b25339a1f323cd5adb820845f5121072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd507f02e356aa650a4e4be41bc000a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5eb9f9cf7552b425817d850c5d7d65fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8a112c82e9c24a40d3fa4f2ed8f011f |
| publicationDate | 2010-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-070811-A1 |
| titleOfInvention | DERIVATIVES OF 1- BENCIL-3- HYDROXIMETHYLENZOL AND ITS USE IN THE TREATMENT OF DISEASES BASED ON THE EXPRESSION OF MCP-1, CX3CR1 AND P40 |
| abstract | Use of 1-benzyl-3-hydroxymethylindazole derivatives for the preparation of a pharmaceutical composition that is active in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40, and its use to treat or prevent diseases based on expression of MCP-1, CX3CR1 and p40. Claim 1: Compound of formula (1) wherein: A may be -X1- or -X1-OC (R9) (R10) -, wherein X1 may be a C1-5 alkyl group optionally substituted with one or more C1-5 alkyl groups or one or more C1-3 alkoxy groups, and R9 and R10, which may be the same or different from each other, may be hydrogen, C1-5 alkyl or C1-3 alkoxy; Y can be N (R11) (R12), N (R13) O (R14), N (R13) N (R14) (R15), N (R13) -X2-N (R14) (R15), N (R13 ) -X2-CO-X3, in which R11 can be hydrogen, a C1-5 alkyl group, C1-3 alkoxy, or R11 together with R12 forms a 4- to 7-membered heterocycle, R12 can be hydrogen, C1- alkyl 5, C1-3 alkoxy, an aryl, heteroaryl, alkylaryl, alkylheteroaryl, COR ', COOR', CON (R ') (Rö) group, with R' and Rö, which may be the same or different from each other, represented by hydrogen and a C1-5 alkyl group, or R12 together with R11 forms a 4- to 7-membered heterocycle, R13 and R15, which may be the same or different from each other, may be hydrogen, C1-5 alkyl or C1-3 alkoxy, R14 it may be hydrogen, C1-5 alkyl, aryl, heteroaryl, alkylaryl, alkylheteroaryl, COR ', COOR', CON (R ') (Rö), with R' and Rö, which may be the same or different from each other, represented by hydrogen and C1-5 alkyl, X2 may be a C1-5 alkyl group, optionally substituted with one or more C1-5 alkyl groups or one or more C1 alkoxy groups -3, X3 may be OH, NH2, NHOH or NHNH2, R1 and R2, which may be the same or different from each other, may be hydrogen, C1-5 alkyl, or a C1-3 alkoxy group, R3, R4 and R8, which may be the same or different from each other, may be hydrogen, C1-5 alkyl, C1-3 alkoxy, a halogen atom, -OH, -N (R ') (Rö), -N (R') CORö, - CN, -CONR'Rö, -SO2NR'Rö, -SO2R ', nitro and trifluoromethyl; with R 'and Rö, which may be the same or different from each other, represented by hydrogen and a C1-5 alkyl group, R5 may be hydrogen, C1-5 alkyl, C1-3 alkoxy, a halogen atom, -OH, - N (R ') (Rö), -N (R') CORö, nitro and trifluoromethyl, or R5 together with one of R6 and R7 forms a ring having 5 or 6 carbon atoms; with R 'and Rö, which may be the same or different from each other, represented by hydrogen and a C1-5 alkyl group, R6 and R7, which may be the same or different from each other, may be hydrogen, a C1-5 alkyl group, or together forming a group C = O, or one of R6 and R7, together with R5, forms a ring having 5 or 6 carbon atoms. |
| priorityDate | 2008-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 69.