http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-070803-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e70c0aeade92d7571d955d3b90ea06e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-58 |
| filingDate | 2009-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9d62112d069494507656bbbaa571a2b0 |
| publicationDate | 2010-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-070803-A1 |
| titleOfInvention | PROCESS FOR THE PREPARATION OF ACID DERIVATIVES 2- AMINO-5- CIANOBENZOICO |
| abstract | Claim 1: A method for preparing a compound of the formula (1) wherein R1 is NHR3 or OR4; R2 is CH3 or Cl; R3 is H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; and R4 is H or C1-4 alkyl; characterized in that it comprises contacting (1) a compound of the formula (2) wherein X is Br or Cl; with (2) a metal cyanide reagent, (3) a copper salt reagent (I), (4) an iodine salt reagent and (5) at least one compound of the formula (3) wherein R5 is H, phenyl or benzyl; or C1-12 alkyl optionally substituted with NR9R10; each R6, R7 and R8 is independently H, C1-12 alkyl, phenyl or benzyl, or R6 and R7 are taken together as -CH = CH-CH = CH-; and R9 and R10 are taken together as -CH = N-CH = CH- optionally substituted with up to 3 substituents independently selected from C1-12 alkyl; with the proviso that when X is Cl, then R2 is methyl. Claim 17: A method of preparing a compound of the formula (4) wherein R2 is CH3 or Cl; R3 is H, C1-4 alkyl, cyclopropyl, cyclopropylcyclopropyl, cyclopropylmethyl or methylcyclopropyl; Z is CR14 or N; R11 is Cl, Br, CF3, OCF2H or OCH2CF3; R12 is F, Cl or Br; R13 is H, F or Cl; and R14 is H, F, Cl or Br; characterized in that it comprises using a compound of formula (1) wherein R1 is NHR3 or OR4; and R4 is H or C1-4 alkyl; wherein said compound of formula (1) is prepared by the method of claim 1. |
| priorityDate | 2008-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.