http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-070437-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 |
| filingDate | 2009-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01d467c8ab43b6003a42cf8de7b47771 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f159f23260a4cb3774363aea583b37b2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b5ce6af00899c64f688384b241ad700 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f69daf39ce0da364a70bb1bba8f7c4dd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45590828fce09c7cdec31e2339d1a132 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_037e59f9554c70ff97c56559eee6d3ba |
| publicationDate | 2010-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-070437-A1 |
| titleOfInvention | BETA MODULATORS - AMILOID |
| abstract | It has been found that the compounds present in the formula (1) are modulators of b-amyloid and therefore can be useful for the treatment or prevention of a disease associated with the deposition of b-amyloid in the brain, in particular the disease Alzheimer's disease and other diseases such as amyloid cerebral angiopathy, hereditary cerebral hemorrhage with Dutch amyloidosis (HCHWA-D), multi-infarction dementia, pugilistic dementia and Down syndrome. Claim 1: A compound of general formula (1) wherein R1 is hydrogen, lower alkyl or lower alkyl substituted by hydroxy; R2 is hydrogen, lower alkoxy, lower alkyl, cyano or halogen; R3 is lower alkyl, lower alkenyl, lower alkyl substituted by fluorine, (CH2) 2O-lower alkyl, (CH2) 2NR82, or is 4H-benzo [1,4] oxazin-3-one, cycloalkyl optionally substituted by hydroxy, or it is alkyl heterocycle, said heterocycloalkyl is optionally substituted by hydroxy or S (O) 2-lower alkyl, or is (CH2) 0,1-aryl or is a five or six link heteroaryl group, said rings are optionally substituted by one or plus R 'for any definition of L, or is halogen, hydroxy, -C (O) O-lower alkyl, OC (O) -alkyl or C (O) NH2 for the case where L is a bond, or it is lower alkoxy, hydroxy, -C (O) O-lower alkyl, OC (O)-lower alkyl or C (O) NH2 for the case where L is -CR6R7-, or is CH2-C (O) O - lower alkyl for the case where L is NR8, or is lower alkoxy, hydroxy or NR82 for the case where L is C (O); R 'is halogen, lower alkyl, lower alkoxy, cyano, lower alkyl substituted by fluorine, lower alkoxy substituted by fluorine, SF5, or is a five-link heteroaryl group, which may be optionally substituted by lower alkyl; Ar is a five-link heteroaryl group or is pyridinyl; Z is CH or N; X-Y is N-CR4 = CR5, CH-CR4 = N, CH-CR4 = CR5 or N-NH; and in which R4 and R5 together with the corresponding carbon atoms to which they are attached can form an additional ring with - (CH2) 3,4, and with the proviso that if XY is CH-CR4 = CR5 or CH- CR4 = N, then Z is N; R4, R5 independently of each other are hydrogen, halogen, lower alkyl, lower alkoxy, C (O) O-lower alkyl, lower alkyl substituted by one or more groups chosen from fluorine, hydroxy, cyano or cycloalkyl, or are cyano, phenyl , benzyl or a heteroaryl group of five or six links, said rings are optionally substituted by one or more R ', or are cycloalkyl or heterocycloalkyl, which are optionally substituted by lower alkyl and hydroxy, and with the proviso that R4 can be hydroxy or NR82; L is a bond, -CR6R7-, -O-, -NR8- or -C (O) -; R6, R7 independently of each other are hydrogen, lower alkyl, cycloalkyl, phenyl or R6 and R7 together with the carbon atom to which they are attached form a C3-6 cycloalkyl group, and with the proviso that R6 can also be hydroxy or lower alkoxy; R8 is hydrogen or lower alkyl; or a pharmaceutically active acid addition salt thereof. |
| priorityDate | 2008-02-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.