http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-070127-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| filingDate | 2009-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-070127-A1 |
| titleOfInvention | PIRROLO - PIRIMIDINAS AND PIRROLO -PIRIDINAS |
| abstract | They are useful for the treatment of diseases mediated by the ALK-5 and / or ALK-4 receptor. Also described are pharmaceutical compositions containing the compounds, and processes for the preparation of the compounds. Claim 1: A compound of the formula (1) in free, salt, and / or solvate form, wherein: T1 is a 4- to 14-membered heterocyclic group linked to the rest of the molecule by means of a carbon atom of the ring, or C4-15 cycloalkenyl, each of which is unsubstituted or independently substituted in one, two, or three positions by R1, C1-8 alkoxy, C3-10 cycloalkyl, C1-8 thioalkyl, halogen, halo-alkyl C1-8, amino, C1-8-amino alkyl, di- (C1-8 alkyl) amino, cyano, oxo, hydroxyl, carboxyl or nitro; T2 is a 4- to 14-membered heterocyclic group linked to the rest of the molecule by means of a ring carbon atom, and unsubstituted or independently substituted in one, two, or three positions by R1, R2, R3, C1-8 alkoxy , C1-8 alkoxycarbonyl, C1-8 thioalkyl, halogen, halo- C1-8 alkyl, amino, C1-8-amino alkyl, di- (C1-8 alkyl) -amino, -C (= O) NR4R5, NH (C = O) R1, -NH (C = O) -C 1-8 alkyl-NR4R5, cyano, oxo, hydroxy, carboxyl or nitro; R 1 is C 1-8 alkyl, C 2-8 alkenyl, or C 2-8 alkynyl unsubstituted or independently substituted in one, two, or three positions by carboxy-C 1-8 alkyl, C 1-8 alkoxy-C 1-8 alkylcarbonyl, hydroxy , oxo, cyano, amino, C1-8-amino alkyl, di- (C1-8 alkyl) -amino, C1-8-alkanoyl, carboxy-C1-8-amino alkyl, C1-8 alkoxy-carbonyl-C1-alkyl -8-amino, N- (carboxy-C1-8 alkyl) -N- (C1-8 alkyl) -amino, N- (C1-8 alkoxy-C1-8 alkyl-alkyl) -N- (C1-8 alkyl ) -amino, amido-C 1-8 alkyl-amino, N-mono- or N, N-di- (C 1-8 alkyl) -amido-C 1-8 alkyl-amino, tri- (C 1-8 alkyl) -silanyl , halogen, C1-8 alkoxy, R3, -C (= O) -R3, -C (= O) NR4R5, -NH (C = O) -C1-8 alkyl, or -SO2NR4R5; R2 is C6-15 aryl, C4-20 cycloalkyl, or C4-15 cycloalkenyl, each of which is unsubstituted or independently substituted in one, two, or three positions by oxo, halogen, hydroxyl, R1, R3, C1- thioalkyl 8, amino, C1-8-amino alkyl, di- (C1-8 alkyl) amino, cyano, carboxyl, nitro, C6-15-oxyl aryl, halo- C1-8 alkyl, -NR4R5, R4R5N-C1-8 alkyl , R4R5N-C1-8 alkoxy, R3-C1-8 alkyl, -O-R1, -O-R3, -C (= O) -R3, -C (= O) -NH2, -C (= O) NR4R5 , -C (= O) -O-R1, -OC (= O) -R1, -SO2-NH2, -SO2-R1, C1-8-SO2-NH- alkyl, -C (= O) -NH- R3, C6-15-SO2-, -SO2-R3 or -SO2NR4R5 aryl; R3 is a 4- to 14-membered heterocyclic group linked by means of a carbon atom or, if it comprises a ring nitrogen atom not linked to a double bond, by means of a ring nitrogen atom or a carbon atom of the ring, and is unsubstituted or independently substituted in one, two, or three positions by oxo, amino, halogen, C1-8-amino alkyl, di- (C1-8 alkyl) -amino, cyano, hydroxyl, carboxyl, nitro, R1 , C1-8 alkoxy, C1-8 thioalkyl, halo- C1-8 alkyl, -C (= O) -R1, -C (= O) -NH2 or -SO2-NH2; R4 and R5 are independently hydrogen, R1, C1-8-amino alkyl, di- (C1-8 alkyl) amino, C6-15 aryl, C6-15 aryl-C1-8 alkyl, C1-8-amino-C1-alkyl -8, di- (C1-8 alkyl) -amino-C1-8 alkyl, -C (= O) -R1, R3 or -C1-8-R3 alkyl; T3 is H, R1, OH or NH2 and X is either N or CH; with the proviso that if X is CH, then T2 is a 4- or 6 to 14-membered heterocyclic group linked to the rest of the molecule by means of a ring carbon atom, and is unsubstituted or independently substituted in one, two, or three positions by R1, R2, R3, C1-8 alkoxy, C1-8 alkoxycarbonyl, C1-8 thioalkyl, halogen, halo- C1-8 alkyl, amino, C1-8-amino alkyl, di- (C1 alkyl -8) -amino, -C (= O) NR4R5, -NH (C = O) R1, -NH (C = O) -C 1-8 alkyl-NR4R5, cyano, oxo, hydroxyl, carboxyl or nitro. |
| priorityDate | 2008-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.