http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-070109-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_60d2134a44f2b4765a9a1a36828c1d8c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| filingDate | 2009-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-070109-A1 |
| titleOfInvention | METHOD FOR SYNTHETIZING TETRAHYDOBIOPTERINE |
| abstract | A method that efficiently produces (6R) -tetrahydrobiopterin with high yield and purity. The method includes the step of hydrolyzing diacetylbiopterin to biopterin under basic conditions in a biphasic mixture comprising an organic phase and an aqueous phase. After substantially completing the hydrolysis of diacetylbiopterin, the aqueous phase containing biopterin can be separated from the organic phase containing most of the organic impurities, which prevents the passage of time input to isolate biopterin in the form of a solid. The aqueous solution containing biopterin is stereoselectively hydrogenated to (6R) -tetrahydrobiopterin under basic conditions and high hydrogen pressure in the presence of a metal catalyst (eg a platinum catalyst). To improve the purification of an acid addition salt of (6R) -tetrahydrobiopterin (eg (6R) -tetrahydrobiopterin dihydrochloride), any residual salt (eg sodium salts) in the aqueous solution can be removed after the reaction of hydrogenation by contacting the aqueous solution with a resin or ion exchange column (eg, cation). Alternatively, the removal of residual salts from the aqueous solution can be omitted if an organic amine (eg, diethylamine or triethylamine) is used rather than an inorganic base in the hydrolysis and / or hydrogenation reactions. |
| priorityDate | 2008-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.