http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-069911-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| filingDate | 2008-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04fbeb5209c87649b889e1020c794317 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e61c37a82585181c52048bd0818d6fbe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bee76c24cb25cd80697be1c70fe0c085 |
| publicationDate | 2010-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-069911-A1 |
| titleOfInvention | BICYCLE DERIVATIVES FOR USE IN THE TREATMENT OF AFFECTIONS ASSOCIATED WITH THE ANDROGEN RECEIVER - 155 |
| abstract | This is related to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of conditions associated with the androgen receptor. Claim 1: A compound characterized in that it is of Formula (1), or a pharmaceutically acceptable salt thereof, for use as a medicament where X3 represents CH or N; represents difluoromethyl, trifluoromethyl or chloro (difluoro) methyl; Y represents CH, COH or N; R14, identically or differently in each occurrence, represents hydrogen or methyl; n and p independently represent 1 or 2; L1 represents a direct link, - (CR9R10) t, - (CR9R10) vO- (CR9R10) v, -N (R11) - (CH2) q -, - S- (O) - or -S (O) 2- ; R9 and R10, identically or differently in each occurrence, represent hydrogen or methyl; q, identically or differently in each occurrence, represents 0, 1, 2 or 3; t represents 1, 2 or 3; v, identically or differently in each occurrence, represents 0, 1 or 2; J represents: aril; a fully saturated monocyclic 3- to 6-membered carbocyclic ring; a monocyclic 4, 5, 6 or 7-membered heterocyclic ring comprising 1, 2, 3 or 4 heteroatoms independently selected from O, N or S; a monocyclic 5- or 6-membered heteroaryl ring comprising 1, 2, 3 or 4 heteroatoms independently selected from O, N or S; or a bicyclic 9 or 10-membered heteroaryl ring system comprising 1, 2, 3, 4 or 5 heteroatoms independently selected from O, N or S; L3 represents a direct link, - (CR9R10) t-, C (O) N (R11) - (CH2) q-, C (O) N (R11) - (CH2) qS (O) 2-, -NR11C ( O) - (CH2) q, -C (O) (CH2) q-, -O- (CH2) q-, -O- (CH2) q-NR11- (CH2) q-, -O- (CH2) qC (O) NR11- (CH2) q-, -S-, -S (O) - or -S (O) 2-; R11 represents hydrogen or methyl; R12 represents: halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, carboxy, C1-6alkoxy, cyano, oxo, fluoroC1-6alkyl, hydroxy, amino, N-C1-4alkyamino or N, N-di-C1-4aIquilamino ; aryl, where the aryl ring is optionally substituted by 1, 2 or 3 substituents selected from R13; a monocyclic 5- or 6-membered heteroaryl ring which comprises 1, 2, 3 or 4 heteroatoms independently selected from O, N or S and where the heteroaryl ring is optionally substituted by 1, 2 or 3 substituents selected from R13; or a heterocyclic ring of 4, 5, 6 or 7 monocyclic members which comprises 1, 2, 3 or 4 heteroatoms independently selected from O, N or S and wherein the heterocyclic ring is optionally substituted by 1, 2 or 3 substituents selected from R13; R13 represents amino, halo, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C2-6alkanoyl, C1-6alkoxyC1-6alkyl, carboxy, cyano, oxo, fluoroC1-6alkyl, hydroxy, hydroxyC1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, N-C1-4alkylamino, N, N-di-C1-4alkylamino or -C (O) NR14R15 where R14 and R15 independently represent hydrogen or methyl; and r represents 0, 1, 2 or 3. |
| priorityDate | 2007-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.