http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-069636-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5d1596f64ec0b2dac5334b2cf05b88bb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 |
| filingDate | 2008-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-069636-A1 |
| titleOfInvention | TRIAZOLO TRIAZINAS AND TRIAZOLOPIRAZINAS REPLACED, PROCEDURE FOR THEIR PREPARATION, MEDICATIONS CONTAINING THEM AND USE OF THE SAME FOR THE TREATMENT AND / OR PROFILAXIS OF HEMATOLOGICAL DISORDERS, SUCH AS NEUTROPENIAS AND LEUCOPENIAS. |
| abstract | Claim 1: Compound of the formula (1) wherein u represents N, V represents CR12, w represents N, A represents CR15; ou represents N, v represents N, w represents CR16, A represents N, where R12 represents hydrogen, hydroxy, amino, hydroxycarbonyl, aminocarbonyl, trifluoromethyl, trifluoromethoxy, cyano, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl ) amino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl, (C1-4 alkyl) carbonylamino, C1-4 alkyl sulfonylamino, 5- or 6-membered heterocyclylcarbonyl, - CH2R13 or -CH2CH2R14, where heterocyclylcarbonyl is substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, oxo, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, (alkyl C1-4) carbonyl, (C1-4 alkoxy) -carbonyl and (C1-4 alkyl) aminocarbonyl, and wherein alkoxy, alkylamino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, alkylcarbonylamino and alkylsulfonylamino may be substituted with a substituent, the substituent being selected from the group consisting of hydroxyl, amino, hydroxycarb onyl, aminocarbonyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl, C1-4 alkylcarbonylamino, 5- or 6-membered heterocyclyl and phenyl, where Phenyl may be substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, cyano, trifluoromethyl, trifluoromethoxy, aminocarbonyl, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, ( C1-4 alkyl) carbonyl, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl and (C1-4 alkyl) carbonylamino, and where heterocyclyl can be substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, oxo, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) -carbonyl and (C1-4 alkyl) aminocarbonyl , and where R13 represents hydroxyl, amino, cyano, hydroxycarbonyl, aminocarbonyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkoxy) carbonyl, (alkyl C1-4) aminocarbonyl, (C1-4 alkyl) carbonylamino or 5- or 6-membered heterocyclyl, wherein alkoxy, alkylamino, alkoxycarbonyl, alkylaminocarbonyl and alkylcarbonylamino may be substituted with a substituent, the substituent being selected from the group consisting of hydroxyl, amino, hydroxycarbonyl , aminocarbonyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl and (C1-4 alkyl) carbonylamino, and where heterocyclyl can be substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, oxo, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) - carbonyl and (C1-4 alkyl) aminocarbonyl, and where R14 represents hydroxyl, amino, cyano, hydroxycarbonyl, aminocarbonyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkoxy) carbonyl, (C1-4 alkyl ) aminocarbonyl, (C 1-4 alkyl) carbonylamino or 5- or 6-membered heterocyclyl, where alkoxy, alkylamin or, alkoxycarbonyl, alkylaminocarbonyl and alkylcarbonylamino may be substituted with a substituent, the substituent being selected from the group consisting of hydroxyl, amino, hydroxycarbonyl, aminocarbonyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl and (C1-4 alkyl) carbonylamino, and where heterocyclyl can be substituted with 1 to 2 substituents, the substituents being independently selected from each other from the group consisting of halogen, oxo, C1-4 alkyl, C1 alkoxy -4, (C1-4 alkyl) amino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) -carbonyl and (C1-4 alkyl) aminocarbonyl, R15 represents hydrogen, halogen, cyano, trifluoromethyl, C1-3 alkyl , methoxy, methylthio or cyclopropyl, R16 represents hydrogen or methyl; represents a remainder of the group of formulas (2) in which * is the point of attachment to the heterocycle, n represents the number 0 or 1; X represents NR10, S or O, where R10 represents hydrogen, C1-3 alkyl or cyclopropyl, Y represents NR11 or S, where R11 represents hydrogen, C1-3 alkyl or cyclopropyl, R3 represents pyrid-2-yl, pyrimid-2- ilo, 2-aminopyrimid-4-yl, 2- (mono- (C1-4 alkyl) -amino) pyrimid-4-yl, 2- (mono-C3-4 cycloalkylamino) pyrimid-4-yl, pyridazin-3 ( 2H) -on-6-yl; 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,2,4-oxadiazol-3-yl, 1,2,3-oxadiazol-4-yl, 1,3-thiazole- 2-yl, 1,3-thiazol-4-yl, 1H-1,2,4-triazol-5-yl, 2,4-dihydro-3H-1,2,4-triazol-3-on-5- yl or 1,2-pyrazol-5-yl, where pyrid-2-yl, pyrimid-2-yl, 1,3-oxazol-2-yl, 1,3-oxazol-4-yl, 1,3-thiazole -2-yl and 1,3-thiazol-4-yl are substituted with 1 or 2 substituents, the substituents being selected independently from each other from the group consisting of halogen, cyano, nitro, amino, trifluoromethyl, trifluoromethoxy, aminocarbonyl, trifluoromethylcarbonyl, alkyl C1-4, C1-4 alkoxy, (C1-4 alkyl) amino, C3-4 cycloalkylamino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl and C3- alkylcarbonyl cycle 6, where alkyl, alkoxy, alkylamino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl and cycloalkylcarbonyl may be substituted with a substituent, the substituent being selected from the group consisting of halogen, cyano, hydroxyl, amino, trifluoromethyl and c C3-5 icloalkyl, and where 2-aminopyrimid-4-yl, 2- (mono- (C1-4 alkyl) -amino) pyrimid-4-yl, 2- (mono-C3-4-cycloalkylamino) pyrinlid-4- ilo, pyridazin-3 (2H) -on-6-yl, 1,2,4-oxadiazol-3-yl, 1,2,3-oxadiazol-4-yl, 1H-1,2,4-triazol-5 -yl, 2,4-dihydro-3H-1,2,4-triazol-3-on-5-yl and 1,2-pyrazol-5-yl may be substituted with a substituent, the substituent being selected from the group consisting of halogen, cyano, nitro, amino, trifluoromethyl, trifluoromethoxy, aminocarbonyl, trifluoromethylcarbonyl, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, C3-4 cycloalkylamino, (C1-4 alkoxy) carbonyl, (C1 alkyl -4) aminocarbonyl and C3-6 cycloalkylcarbonyl, R4 represents hydrogen, C1-3 alkyl or cyclopropyl, R5 represents hydrogen or C1-3 alkyl, R6 represents hydrogen, C1-3 alkyl or cyclopropyl, R7 represents hydrogen or C1-3 alkyl, R8 represents hydrogen, C1-3 alkyl or cyclopropyl, R9 represents hydrogen or C1-3 alkyl, R2 represents C5-10 aryl or 5-10 membered heteroaryl, where of aryl and heteroaryl may be substituted with 1 to 3 substituents, the substituents being selected independently from each other from the group consisting of hydroxy, hydroxymethyl, amino, halogen, cyano, trifluoromethyl, trifluoromethoxy, aminocarbonyl, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkoxy) methyl, (C1-4 alkyl) amino, (C1-4 alkyl) -aminomethyl, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl, ( C1-4 alkyl) carbonylamino, (C1-4 alkyl) sulfonyl, (C1-4 alkyl) sulfonylamino, (C1-4 alkyl) -aminosulfonyl, phenyl, benzyloxy, 5- or 6-membered heterocyclyl, 5- or 6-membered heterocyclylcarbonyl, 5 or 6-membered heterocyclylmethyl and 5 or 6-membered heteroaryl, where phenyl, benzyloxy, heterocyclyl, heterocyclylcarbonyl, heterocyclylmethyl and heteroaryl may be substituted with 1 to 3 substituents, the substituents being independently selected from each other from the group consisting of halogen, cyano, trifluoromethyl, trifluoromethoxy, a minocarbonyl, C1-4 alkyl, C1-4 alkoxy, (C1-4 alkyl) amino, (C1-4 alkyl) carbonyl, (C1-4 alkoxy) carbonyl, (C1-4 alkyl) aminocarbonyl and (C1-4 alkyl) carbonylamino, or two of the aryl substituents together with the carbon atoms to which they are attached form a 1,3-dioxolane or 1,4-dioxane; or one of its salts, its solvates or the solvates of its salts. |
| priorityDate | 2007-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 75.