http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-069628-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02A50-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 |
| filingDate | 2008-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2010-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-069628-A1 |
| titleOfInvention | DERIVATIVES OF AMINOTIAZOLES, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES OF THE SAME FOR THE TREATMENT OF BACTERIAL INFECTIONS. |
| abstract | Claim 1: A compound of the formula (1) and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, diastereomers, atropisomers, or racemates thereof, including the pyridine N-oxide thereof; where: R1 is -Z-CO2H and -A-Z-CO2H; R1a is hydrogen, -Z-CO2H, and -A-Z-CO2H, where, if R1a is hydrogen, then the residue Z of R1 is substituted by at least two CO2H groups; or R1 and R1a, taken in combination, form a saturated, partially unsaturated or aromatic heterocycle, having 4 to 7 ring atoms, and having 0 to .3 additional ring heteroatoms selected from N, O and S , wherein the heterocycle is substituted by at least two residues independently selected from CO2H, -Z-CO2H, and -AZ-CO2H; A is independently selected in each presentation, from the group consisting of a -C (O) -, -C (O) O-, -C (O) N (R8a), -S (O) 2-, - S (O) -, -C (H) = N-, -S (O) 2N (R8a) -, and -S (O) N (R8a) -; Z is alkylene of 1 to 10 carbon atoms, cycloalkylene of 3 to 8 carbon atoms, heterocycle-alkylene of 3 to 8 carbon atoms, phenylene, or heteroarylene of 5 to 6 members, each of which is optionally substituted with one or more groups independently selected from alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, hydroxyl, amino, mono- and di-alkyl of 1 to 6 carbon-amino atoms, C (O) OH, or halogen; R2a is selected from the group consisting of H, substituted or unsubstituted alkyl, OH, OR4, OC (O) R4a, OC (O) N (R8a) 2 and N (R8a) 2; R2b is selected from the group consisting of absent, H, and alkyl, or R2a and R2b can form together = O or = NH; R3 and R12 are each independently selected from the group consisting of H, halogen, OR4b, -A-J, and N (R8a) 2; R4a is selected from the group consisting of H, and alkyl; R4b is selected from the group consisting of alkyl and - (CH2-CH2-O-) n-R9, where n is an integer from 1 to 500, 1,000, 2,000, 3,000, 4,000, 5,000, 10,000, 20,000, 30,000, 40,000, 50,000, or 60,000 or is an average of a plurality of integers that has a value of 1 to 500, 1,000, 2,000, 3,000, 4,000, 5,000, 10,000, 20,000, 30,000, 40,000, 50,000, or 60,000; R5 is selected from the group consisting of H, alkyl, and R4b; J is selected from the group consisting of H, F, O-alkyl, N (R8a) 2, N + (R8a) 3, N (R8a) C (O) alkyl, CO2H, C (= O) N (R8a ) 2, CO2-alkyl, P (O) - (OH) 2, P (O) - (O-alkyl) 2, and a heterocycle containing substituted nitrogen; R8a is absent, or is selected from the group consisting of H, - (alkyl) -, - (cycloalkyl) -, C (alkyl) 2-J, R4b, where R8A can also be cycled with the atom with which R8a is linked, to form a 3, 4, 5, 6 or 7-membered ring that is aromatic or non-aromatic, and may contain one or more heteroatoms, wherein the ring may be further substituted one or more times with substituents that are same or different; and R9 is selected from the group consisting of H, alkyl and CH2CO2H. |
| priorityDate | 2007-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 33.