http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-069412-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7dffbd04747d5d9b9492e7f2ac61db6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| filingDate | 2008-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_36bbb548999333efe6937d51ea766af9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bceb94da1bd990d5fe417e58a0893d40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f35d12fce1cf2abfb6318a5005185598 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46aca5a97be0aa0cb8e9e39e6353bc6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3f8c065c3e89d4e2d5999dd2820a2735 |
| publicationDate | 2010-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-069412-A1 |
| titleOfInvention | PIRIMIDINE DERIVATIVES, PROCESS TO PREPARE THEM, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME IN THE TREATMENT OF VIRAL, BACTERIAL AND ALLERGIC DISEASES, AMONG OTHERS. |
| abstract | Claim 1: A compound characterized in that it is of formula (1) wherein R 1 represents C 1-6 alkyl, C 1-6 alkoxy or C 1-6 alkylthio; R2 represents either the compound of formula (2) or the compound of formula (3); R3 represents an H atom or a C1-3 alkyl group; R4 represents, (i) C3-8 cycloalkyl, C1-8 alkyl, C2-8 alkenyl or C2-8 alkynyl, each of which may be optionally substituted with one or more substituents independently selected from halogen, hydroxyl, C1- alkoxy 6, C1-6 alkylthio, and C3-6 cycloalkyl, or (ii) a group of formula (4) in which m is 1 or 2, q is 0, 1 or 2 and each R independently represents a halogen atom or a hydroxyl, methyl, cyano, trifluoromethyl, S (O) h-methyl or methoxy group; X1 represents an oxygen or sulfur atom or an NH or CH2 group; X2 and X4 each independently represent an oxygen or sulfur bond or atom; R5 and R5a each independently represent a hydrogen atom or a C1-3 alkyl group; R6 represents a C1-6 alkyl group optionally substituted with one or more substituents independently selected from halogen, cyano, hydroxyl, C1-3 alkoxy, methylsulfonyl, methylthiazolyl and NR10R11, or R6 represents a saturated heterocyclic ring, optionally substituted with C1-6 alkyl ; j is 1 or 2; each R7 independently represents a hydrogen or halogen atom or a hydroxyl, methyl, cyano, halomethoxy or methoxy group; Z1 represents a C2-6 alkylene or C3-8 cycloalkylene group; X3 represents NR12,> N-COR12, CONR12, NR12CO, SO2NR12,> N-SO2R12, NR12SO2, NR12CONR13 or NR13CONR12, S (O) p or O; p is 0, 1 or 2; Y1 represents a single bond or C1-6 alkylene; A represents a monocyclic or bicyclic C6-10 aryl group or a monocyclic or bicyclic C5-12 heteroaryl group containing 1 to 3 ring heteroatoms; R8 represents a C1-6 alkyl group optionally substituted with one or more substituents independently selected from halogen, cyano, hydroxyl, NR10R11 and C1-3 alkoxy, n is 0, 1 or 2; each R9 independently represents halogen, cyano, hydroxy, thiol, C1-3 alkyl, C1-3 hydroxyalkyl, C1-3 haloalkyl, C1-3 alkoxy, C1-3 haloalkoxy, C1-3 alkylthio, C1-3 alkylsulfonyl or C1- alkylsulfinyl 3; R10 and R11 each independently represent hydrogen, C1-6 alkyl or C3-6 cycloalkyl, or R10 and R11 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring of 4 to 7 members which may optionally contain another heteroatom in the ring selected from oxygen, S (O) or NR36, the heterocyclic ring may be optionally substituted with C1-6 alkyl (which in turn may be optionally substituted with C1-6 alkoxy) or di- C1-6 alkylamino; R12 represents a hydrogen atom, a saturated or unsaturated heterocyclic ring of 3 to 8 members comprising at least one O, S (O) t, N or NR14 group, a C1-6 alkyl or C3-6 cycloalkyl group , the last two groups may be optionally substituted with one or more substituents independently selected from NR15R16 and R17, or R12 is a C1-6 alkylene which may be attached to a carbon atom within a Z1 C2-6 alkylene group so as to form a saturated ring of 4 to 7 members containing nitrogen; R14, R22 and R35 each independently represents a hydrogen atom, CO2R18, S (O) wR18, COR19, or a C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl or C3-8 cycloalkyl group, each of which may be optionally substituted with one or more substituents independently selected from halogen, cyano, OR20 and NR20R21; R15 and R16 each independently represents a hydrogen atom, a saturated heterocyclic ring of 3 to 8 members comprising at least one O, S (O) zo NR22, C1-6 alkyl or C3-6 cycloalkyl group, which may be the last two groups will be optionally substituted with one or more substituents independently selected from halogen, cyano, S (O) aR23, OR24, CO2R24, OC (O) R24, SO2NR24R25, CONR24R25, NR24R25, NR24SO2R26, NR24COR25, or a saturated heterocyclic ring 3 to 8 members comprising in the ring at least one group O, S (O) or NR25, or R15 and R16 together with the nitrogen atom to which they are attached form a saturated heterocyclic ring of 3 to 8 members comprising a nitrogen atom in the ring and optionally one or more heteroatoms in the ring independently selected from nitrogen, oxygen, sulfur and sulfonyl, the heterocyclic ring may be optionally substituted with one or more substituents selected s independently between halogen, cyano, S (O) dR27, OR27, CO2R27, COR27, OC (O) R27, SO2NR27R28, CONR27R28, NR27R28, NR27SO2R29, NR27COR28, C1-6 haloalkyl, C3-8 cycloalkyl, C1-6 alkyl, aryl and heteroaryl, the last four groups being optionally substituted with one or more substituents independently selected from halogen, cyano, S (O) fR30, OR30, CO2R30, SO2NR30R31, CONR30R31 and NR30R31; R17 represents halogen, cyano, C1-3 haloalkoxy, CO2R32, S (O) gR32, OR32, SO2NR32R34, CONR32R34, NR32SO2R33, NR32CO2R33, NR32COR4 or a saturated heterocyclic ring of 3 to 8 members comprising an NR35 group in the ring; a, b, d, f, g, h, t, v, w and z each independently represents 0, 1 or 2; R18, R26, R29 and R33 each independently represents a C1-6 alkyl or C3-6 cycloalkyl group; R13, R19, R20, R21, R23, R24, R25, R27, R28, R30, R31, R32 and R34 each independently represents a hydrogen atom or a C1-6 alkyl or C3-6 cycloalkyl group; and R36 represents a hydrogen atom or a C1-3 alkyl group; or one of its pharmaceutically acceptable salts. |
| priorityDate | 2007-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.