http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-068888-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D515-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D285-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 |
| filingDate | 2008-10-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-12-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-068888-A1 |
| titleOfInvention | DERIVATIVES OF 1, 3, 4 - TIADIAZOL, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN THE PREPARATION OF MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE INHIBITION OF KSP KINESIN. |
| abstract | Pharmaceutical compositions (including compositions for pharmaceutical use) comprising these compounds, alone and in combination with one or more additional therapeutic agents, and their use in medicaments for the inhibition of KSP kinesin activity, and for treating cell proliferative diseases or disorders associated with KSP kinesin activity. Claim 1: A compound having the general structure shown in formula (1), or a salt, solvate, ester, prodrug, or isomer acceptable for pharmaceutical use thereof wherein X, R1, R2, R3, p, E , ring A, and ring B are independently selected from each other and where p is 0, 1, 2, 3 or 4; X is selected from the group consisting of S, S (O), and S (O) 2; Ring A (including E and the unsaturation shown) is a 4- to 8-membered cycloalkenyl or heterocycloalkenyl ring; E is selected from the group consisting of -O-, -S-, -S (O) -, -S (O) 2-, -C (R4) (R5) -, -N (R6) -, -N ( C (Y) R7) -, -N (C (Y) OR8) -, -N (C (Y) N (R9) (R10)) -, -C (O) -N (R11) -, -N (R11) -C (O) -, -S (O) 2-N (R11) -, -N (R11) -S (O) 2-, -C (O) -O-, -OC (O) -, -ON (R6) -, -N (R6) -O-, -N (R6) -N (R12) -, -N = N-, -C (R7) = N-, -C (O) -C (R7) = N-, -C (O) -N = N-, -OC (Y) -N (R11) -, -N (R11) -C (Y) -O-, -N (R11 ) -C (Y) -N (R12) -, -C (Y) -N (R11) -O-, -C (Y) -N (R11) -N (R12) -, -ON (R11) - C (Y) -, and -N (R12) -N (R11) -C (Y) -, where each Y is independently selected from the group consisting of (= O), (= S), (= N (R13) ), (= N (CN)), (= N (OR14), (= N (R15) (R16)), and (= C (R17) (R18)); Ring B is an aromatic or heteroaromatic ring, or a partially unsaturated alicyclic ring, or a partially unsaturated heterocyclic ring, wherein said ring is unsubstituted or optional and independently substituted with one or more substituents, which may be the same or different, each substituent is independently selected from the group consisting of halogen, -CN, -NO2, alkyl , heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, arylalkyl-, heteroaryl-alkyl-, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido, -OR19, -OC (O) OR20, -NR21SO22, -NR23SO22, -NR21SO22, -NR21SO22, -NR21SO22, -NR21SO22, -NR21SO22, -NR21SO22 , -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26; R1 is selected from the group consisting of aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, and heterocycloalkenyl, where each said aryl, each said heteroaryl, each said cycloalkyl, each said cycloalkenyl, each said heterocycloalkyl, and each said heterocycloalkenyl is unsubstituted or optional and independently substituted with one or more substituents, which may be the same or different, each substituent is independently selected from the group consisting of halogen, -CN, -NO2, alkyl, heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, arylalkyl-, heteroaryl-alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido, -OR19, -OC (O) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, - SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26; R2 is selected from the group consisting of -C (Z) R7, -C (Z) NR9R10, -C (Z) OR8, -SO2NR9R10, alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, and heterocycloalkenyl, where each Z is independently selected from the group consisting of (= O), (= S), (= N (R13)), (= N (CN)), (= N (OR14), (= N (R15) (R16) ), and (= C (R17) (R18)), and where each said alkyl, each said heteroalkyl, each said aryl, each said heteroaryl, each said cycloalkyl, each said cycloalkenyl, each said heterocycloalkyl, and each said heterocycloalkenyl is not substituted or optional and independently substituted with one or more substituents, which may be the same or different, each substituent is independently selected from the group consisting of oxo (with the proviso that said aryl and said heteroaryl are not substituted with oxo), halogen, - CN, -NO2, alkyl, heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, aryl-al chyl, heteroaryl-alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido, -OR19, -OC (O) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, - C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and - NR23C (O) NR25R26; each R3 (when present) is independently selected from the group consisting of alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halogen, -CN, -NO2, -OR19, - OC (O) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (S) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26, -NR23C (O) NR25R26, and -NR23-C (NH ) -N (R26) 2, wherein each said alkyl, each said heteroalkyl, each said alkenyl, each said heteroalkenyl, each said alkynyl, each said heteroalkynyl, each said aryl, each said heteroaryl, each said cycloalkyl, each said cycloalkenyl, each said heterocycloalkyl, and each said heterocycloalkenyl is unsubstituted or optional and independently substituted with one or more substituents, which may be the same or different, each substituent is independently selected mind of the group consisting of oxo, halogen, -CN, -NO2, alkyl, heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido, -OR19, -OC (O ) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26, or, alternatively, when p is 2, 3 or 4, any of the two R3 groups attached to the same carbon atom of the ring are taken together with the carbon atom to which they are attached to form a spirocycloalkyl, spirocycloalkenyl, or spiroheterocycloalkyl ring containing from one to three ring heteroatoms independently selected from the group consisting of -NH-, -NR6-, -S-, -S (O) -, -S (O) 2-, and -O-, or a spiroheterocycloalkenyl ring containing one to three ring heteroatoms independently selected d the group consisting of -NH-, -NR6-, -S-, -S (O) -, -S (O) 2, and O-, or, alternatively, R2 and R3, together with the atom to which these they are attached, taken together with the carbon atom to which they are attached to form a cycloalkyl, cycloalkenyl, heterocycloalkyl ring containing from one to three ring heteroatoms independently selected from the group consisting of -NH-, -NR6-, -S -, -S (O) -, -S (O) 2-, and -O-, or a heterocycloalkenyl ring containing one to three ring heteroatoms independently selected from the group consisting of-NH-, -NR6-, - S-, -S (O) -, -S (O) 2-, and O-; each R4 (when not bound with R5) is independently selected from the group consisting of H, alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halogen, -CN, -NO2 , -OR19, -OC (O) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19 , -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26, where each said alkyl, each heteroalkyl, each said alkenyl, each said heteroalkenyl, each said alkynyl, each said heteroalkynyl, each said aryl, each said heteroaryl, each said cycloalkyl, each said cycloalkenyl, each said heterocycloalkyl, and each said heterocycloalkenyl is unsubstituted or optional and independently substituted with one or more substituents, which may be the same or different, each substituent is independently selected from the integrated group p or oxo, halogen, -CN, -NO2, alkyl, heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido, -OR19, -OC (O) OR20, - NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, - OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26 each R5 (when not binding with R4) is independently selected from the group consisting of H, alkyl, heteroalkyl , alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, halogen, -CN, -NO2,, -OR19, -OC (O) OR20, -NR21R22, -NR23SO2C24, -NR23SO2R24, -NN23 ) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19, -S (O) R19, -SO2R19, -OC (O) R24, -C ( O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26, where each said alkyl, each said heteroalkyl, each said alkenyl, each said heteroalkenyl, c ada said alkynyl, each said heteroalkynyl, each said aryl, each said heteroaryl, each said cycloalkyl, each said cycloalkenyl, each said heterocycloalkyl, and each said heterocycloalkenyl is unsubstituted or optional and independently substituted with one or more substituents, which may be Same or different, each substituent is independently selected from the group consisting of oxo, halogen, -CN, -NO2, alkyl, heteroalkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, aryl, heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, azido , -OR19, -OC (O) OR20, -NR21R22, -NR23SO2R24, -NR23C (O) OR20, -NR23C (O) R24, -SO2NR25R26, -C (O) R24, -C (O) OR20, -SR19 , -S (O) R19, -SO2R19, -OC (O) R24, -C (O) NR25R26, -NR23C (N-CN) NR25R26 and -NR23C (O) NR25R26; or, alternatively, R4 and R5, together with |
| priorityDate | 2007-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.