http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-068124-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 |
| filingDate | 2008-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-068124-A1 |
| titleOfInvention | DERIVADOS DE FENIL - ISOQUINOLINA AND FENIL - QUINAZOLINA |
| abstract | This refers to substituted phenyl-isoquinoline and phenyl-quinazoline derivatives and their pharmaceutical uses in the prevention or treatment of bone conditions that are associated with increased calcium intake or resorption, or where stimulation of formation is desirable. of bone and the fixation of calcium in the bone, processes of obtaining said derivatives and pharmaceutical compositions that comprise them. Claim 1: A compound of the formula (1) or a pharmaceutically acceptable salt thereof, or if possible, tautomers thereof: wherein: Y is CH or N; and R1 is methyl, ethyl, isopropyl, terbutyl, or cyclopropyl; and R2 is methyl, ethyl, propyl, 2-propenyl or 2-propynyl; and R3 is hydrogen, chlorine, fluorine, bromine, iodine, hydroxyl, methoxy. methyl, or trifluoro-methyl; and R4 is hydrogen, chlorine, fluorine, bromine, iodine, hydroxyl, methoxy, methyl, or trifluoro-methyl; and A is a heterocyclic, or bi- or tri-cyclic carbon ring system, of which one, two, or three cycles may be aryl or hetero-aryl, and each of which is optionally substituted one or more times; or wherein a bicyclic or tricyclic system as described above, contains 7 to 13 ring atoms; or wherein a bicyclic or tricyclic system as described above, contains 7 to 13 ring atoms, one or more of which are selected from the group of O, N, S or C = O; or wherein the substituent or optional substituents are independently selected from the group consisting of phenyl, hydroxyl, trifluoro-methyl, methyl, ethyl, branched or unbranched C3-4 alkyl, 2-thiophene, 3-thiophene, hydroxymethyl, hydroxyethyl, methylcarbonyloxy methyl, ethylcarbonyloxy ethyl, carboxy methyl, carboxy ethyl, methoxycarbonyl, ethoxycarbonyl, C3-4 alkyloxy branched or unbranched carbonyl, methoxy, ethoxy, branched C3-4 alkyloxy or unbranched, C3-5 alkyloxy-branched or unbranched methyl-carbon, branched or unbranched C3-6-carbonyl-ethyl alkyloxy, methylcarbonyl, ethylcarbonyl, branched or unbranched C3-4-carbonyl alkyl, phenyl -carbonyl, chlorine, fluorine, bromine, iodine, cyano, nitro, furanyl, pyrrolyl, thiazolyl, benzothiazolyl, pyridinyl, amino, sulfanyl, sulfonyl, oxycarbonyl, sulfinyl, amino-sulfonyl, sulfonyl-amino, carbonyl, carbonyloxy, carbonyl-amino , carboxyl, acyl, acyl-amino, or carbamoyl ; or wherein the optional substituents or substituents as defined above, may again be optionally substituted by one or more substituents of the group consisting of methyl, ethyl, branched or unbranched C3-4 alkyl, fluorine, chlorine, bromine, iodine , trifluoro-methyl, hydroxy, methoxy, amino, alkyl-amino, dialkyl-amino, cyano, carboxyl, methyl-carboxy, ethyl-carboxyl, branched or unbranched C3-5-carboxy alkyl, acetyl, 2-hydroxy-ethyl and 3-hydroxypropyl. |
| priorityDate | 2007-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.