http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-068016-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ab29b52a19d65879e70b22bb846a2cf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-10 |
| filingDate | 2008-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-068016-A1 |
| titleOfInvention | DERIVATIVES OF BENCILBENCENO, A PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN THE TREATMENT OF DISEASES MEDIATED BY SGLT |
| abstract | Compounds with the inhibitory effect of the SGLT sodium dependent glucose cotransporter are presented. Pharmaceutical compositions, and use of the compounds, independently or in combination with other therapeutic agents, for the treatment of diseases or disorders that are affected by the inhibition of SGLT are also disclosed. Claim 1: A compound of Formula (1) in which V is a member selected from the group consisting of oxygen; sulfur; SW; SO2; and a simple link; W is a member selected from the group consisting of C 1-6 alkylene, C 2-6 alkenylene, C 2-6 alkynylene, C 3-10 cycloalkylene, C 5-10 cycloalkenylene, or (C 3-10 cycloalkylene) (C 1-6 alkylene) where the C3-10 cycloalkylene portion is attached to V and the C1-6 alkylene portion is linked to X, and where the alkylene, alkenylene, alkynylene, cycloalkylene and cycloalkenylene groups and portions may be optionally partially or fully fluorinated and may be mono- or disubstituted with substituents independently selected from the group consisting of chlorine, hydroxy, C1-3 alkyl, C1-3 alkoxy, C3-6 cycloalkyl, C3-6 cycloalkyloxy, C5-10 cycloalkenyl or C5-10 cycloalkenyloxy groups, and in the cycloalkylene groups or portions and cycloalkenylene, optionally one or two methylene groups are replaced, independently of each other, by O, S, CO, SO, SO2 or NRb, and optionally one or two methine groups are replaced by N; X is a member selected from the group consisting of oxygen; sulfur; SW; and SO2; Y is a member selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C5-10 cycloalkenyl, (C3 cycloalkyl) -10) C1-4 alkyl, (C5-10 cycloalkenyl) C1-3 alkyl, (C3-10 cycloalkyl) C2-4 alkenyl, C3-6 cycloalkylmethyl, (C5-10 cycloalkenyl) C2-4 alkenyl, (C1- alkyloxy 4) C1-3 alkyl, (C2-4 alkenyloxy) C1-3 alkyl, (C3-10 cycloalkyloxy) C1-3 alkyl, (C5-10 cycloalkenyloxy) C1-3 alkyl, (amino) C1-3 alkyl, (alkylamino C1-4) C1-3 alkyl, di- (C1-3 alkylamino) C1-3 alkyl, (C1-6 alkyl) carbonyl (C1-3) alkyl, (C2-6 alkenyl) carbonyl (C1-3) alkyl, (alkynyl C2-6) (C1-3) carbonylalkyl, (arylcarbonyl) C1-3 alkyl, (heteroarylcarbonyl) C1-3 alkyl, (C1-6 alkylsulfonyl) C1-3 alkyl, (C2-6 alkenylsulfonyl) C1-3 alkyl, ( C2-6 alkylsulfonyl) C1-3 alkyl, (arylsulforyl) C1-3 alkyl, (heteroarylsulfonyl) C1-3 alkyl, (C1-6 alkyl) aminocarbonylalkyl (C1-3) alkyl, (alkenyl C 2-6) aminocarbonylalkyl (C1-3), (C2-6 alkynyl) aminocarbonylalkyl (C1-3), (arylaminocarbonyl) C1-3 alkyl, (heteroarylaminocarbonyl) C1-3 alkyl, (C1-6 alkyl) carbonyl, (alkenyl C2-6) carboniIo, (C2-6 alkynyl) carbonyl, arylcarbonyl, heteroarylcarbonyl, (C1-6 alkyl) sulfonyl, (C2-6 alkenyl) sulfonyl, (C2-6 alkynyl) sulfonyl, arylsulfonyl and heteroarylsulfonyl; wherein the alkyl, alkenyl, alkynyl, cycloalkyl and groups or portions are optionally partially or completely fluorinated and are optionally mono or disubstituted with substituents independently selected from the group consisting of chlorine, hydroxy, C1-3 alkyl, C1-3 alkoxy, C3 cycloalkyl -6, C3-6 cycloalkyloxy, C5-10 cycloalkenyl, C5-10 cycloalkenyloxy, and NRbRc, and in the cycloalkyl and cycloalkenyl groups or portions, optionally one or two methylene groups are replaced, independently of each other, by O, S, CO , SO, SO2 or NRb, and optionally one or two methine groups are replaced by N, where the heterocycle formed by said optional replacement is not heteroaryl, and where when V is a member selected from the group consisting of oxygen, sulfur and a bond simple and W is C1-6 alkylene, then Y is not hydrogen or C1-6 alkyl; and when V is oxygen, W is C3-10 cycloalkylene and X is oxygen, then Y is not hydrogen, C1-6 alkyl or trifluoromethyl; and when V is a single bond and W is a member selected from the group consisting of C2-6 alkenylene, C2-6 alkynylene, C3-10 cycloalkylene and C5-10 cycloalkenylene, then Y is not hydrogen, C1-6 alkyl or ( C3-10 cycloalkyl) C1-4 alkyl; and when V is a member selected from the group consisting of oxygen, sulfur, SO and SO2, W is a member selected from the group consisting of C2-6 alkenylene and C2-6 alkynylene, and Y is a member selected from the group consisting of in C3-10 cycloalkyl and C5-10 cycloalkenyl, then X can also represent a single bond; or optionally, X is NRa and Y is a member selected from the group consisting of C1-6 alkylsulfonyl, C2-6 alkenylsulfonyl, C2-6 alkylsulfonyl, arylsulfonyl, heteroarylsulfonyl, C1-6 alkylsulfinyl, arylsulfinyl, heteroarylsulfinyl, (C1-6 alkyl ) carbonyl, (C2-6 alkenyl) carbonyl, (C2-6 alkynyl) carbonyl, arylcarbonyl, heteroarylcarbonyl, (C1-6 alkyl) aminocarbonyl, (C2-6 alkenyl) aminocarbonyl, (C2-6 alkynyl) aminocarbonyl, arylaminocarbonyl, heteroarylaminocarbonyl , (C1-6 alkylsulfonyl) C1-3 alkyl, (C2-6 alkenylsulfonyl) C1-3 alkyl, (C2-6 alkylsulfonyl) C1-3 alkyl, (arylsulfonyl) C1-3 alkyl, (heteroarylsulfonyl) C1-3 alkyl, (C1-6 alkylsulfinyl) C1-3 alkyl, (arylsulfinyl) C1-3 alkyl, (heteroarylsulfinyl) C1-3 alkyl, (C1-6 alkyl) aminocarbonylalkyl (C1-3), (C2-6 alkenyl) aminocarbonylalkyl (C1- 3), (C2-6 alkynyl) C1-3 aminocarbonylalkyl), (arylaminocarbonyl) C1-3 alkyl and (heteroarylaminocarbonyl) C1-3 alkyl; where the alkyl, alkenyl and alkynyl portions are optionally partially or completely fluorinated and when Ra is a member selected from the group consisting of H and (C1-4 alkyl) carbonyl, then Y is not (C1-6 alkyl) carbonyl or arylcarbonyl; Z is a member selected from the group consisting of oxygen; sulfur; SW; SO2; 1,1-cyclopropylene; carbonyl; and methylene optionally substituted with one to two substituents independently selected from halo, hydroxy, C1-6 alkyl, C1-6 alkoxy, C3-6 cycloalkyl and C3-6 cycloalkyloxy; each of R1, R2 and R3 is a member independently selected from the group consisting of hydrogen, halo, hydroxy, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C5-10 cycloalkenyl, alkyloxy C1-6, C3-10 cycloalkyloxy, cyano and nitro, where the alkyl and cycloalkyl groups or portions are optionally mono- or polysubstituted with fluorine, or when R1 and R2 are attached to two adjacent C atoms, R1 and R2 are optionally linked each other to form a C3-5 alkylene, C3-5 alkenylene or butadienylene bridge, which is optionally partially or completely fluorinated and is optionally mono or disubstituted with identical or different substituents selected from chlorine, hydroxy, C1-3 alkoxy and C1 alkyl -3, and where one or two methylene groups are optionally replaced, independently of one another, by O, S, CO, SO, SO2 or NRb, and where one or two methine groups are optionally replaced by N; each of R4 and R5 is a member independently selected from the group consisting of hydrogen, halo, cyano, nitro, hydroxy, C1-6 alkyl, C3-10 cycloalkyl, C1-3 alkyloxy and C3-10 cycloalkyloxy, where the groups o alkyl and cycloalkyl portions are optionally mono or polysubstituted with fluorine, or when R4 and R5 are attached to two adjacent C atoms, optionally and join together to form a C3-5 alkylene, C3-5 alkenylene or butadienylene bridge, which it is optionally partially or completely fluorinated and is mono or disubstituted with identical or different substituents selected from chlorine, hydroxy, C1-3 alkoxy and C1-3 alkyl, and where one or two methylene groups are optionally replaced, independently of each other, by O, S, CO, SO, SO2 or NRb, and where one or two methine groups are optionally replaced by N; each of R6, R7, R8 and R9 is a member independently selected from the group consisting of hydroxy, (C1-18 alkyl) carbonyloxy, (C1-18 alkyl) oxycarbonyloxy, arylcarbonyloxy, aryl- (C1-3 alkyl) carbonyloxy, (C3-10 cycloalkyl) carbonyloxy, hydrogen, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, () C3-10 cycloalkyl-C1-3 alkyl, cycloalkenyl (C5-7) alkyl ( C1-3), aryl (C1-3) alkyl, heteroaryl (C1-3) alkyl, C1-6 alkyloxy, C2-6 alkenyloxy, C2-6 alkynyloxy, C3-7 cycloalkyloxy, C5-7 cycloalkenyloxy, aryloxy, heteroaryloxy, (C3-7) cycloalkyl (C1-3) alkyloxy, (C5-7) cycloalkenyl - (C1-3) alkyloxy, aryl (C1-3) alkyloxy, heteroaryl (C1-3) alkyloxy, aminocarbonyl, hydroxycarbonyl, (C1-4 alkyl) aminocarbonyl di- (C1-3 alkyl) aminocarbonyl, (C1-4 alkyloxy) carbonyl, aminocarbonyl (C1-3 alkyl), (C1-4 alkyl) aminocarbonyl (C1-3 alkyl) , di- (C1-4 alkyl) aminocarbonylalkyl- (C1-3), hydroxycarbonyl- (C1-3) alkyl, (C1-4 alkyloxy) carbonyl (C1-3) alkyl, cycloalkyloxy (C3-7) - (C1-3) alkyl, (C5-7) cycloalkenyloxy - (C1-3) alkyl, aryloxy (C1-3) alkyl, heteroaryloxyalkyl- (C1-3), C1-4 alkylsulfonyloxy, arylsulfonyloxy, aryl-alkyl ( C1-3) -sulfonyloxy, trimethylsilyloxy, t-butyldimethylsilyloxy, and cyano; wherein the alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups or portions are optionally partially or completely fluorinated and are optionally mono or disubstituted with substituents independently selected from chloro, hydroxy, C1-3 alkoxy and C1-3 alkyl, and in the groups or cycloalkyl and cycloalkenyl portions, optionally one or two methylene groups, independently of one another, is replaced by NRb, O, S, CO, SO or SO2; when Y is hydrogen or C1-6 alkyl then both R8 and R9 are hydroxy; each Ra is a member independently selected from the group consisting of H, C1-6 alkyl, C3-6 cycloalkyl and (C1-4 alkyl) carbonyl, where the alkyl and cycloalkyl groups or portions are optionally partially or completely fluorinated; each Rb is a member independently selected from the group consisting of H, C1-4 alkyl and (C1-4 alkyl) carbonyl, where the alkyl groups or portions are optionally partially or completely fluorinated are opted |
| priorityDate | 2007-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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