http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-066880-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_686b75258c1c38e88df3a897728e579e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2602-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2603-28 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C317-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-79 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C235-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| filingDate | 2008-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-066880-A1 |
| titleOfInvention | BENZOILAMINO-IDAN-2-SUBSTITUTED CARBOXILIC ACIDS AND RELATED COMPOUNDS |
| abstract | The compounds herein have CXCR5 inhibitory activity and are particularly useful in the treatment or prevention of various inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, lupus or Crohn's disease, associated with modulation of the human CXCR5 receptor. Claim 1: A compound of the formula (1) wherein: A is CH = CH or S; R23 is hydrogen, halogen, (C1-4) alkyl, (C1-4) alkyloxy, (C1-4) alkyl -S- or nitro; R24 is hydrogen or halogen when A is CH = CH, or is hydrogen, halogen, (C1-4) alkyl, (C1-4) alkyloxy, (C1-4) -S- alkyl, or nitro when A is S; X is N (H) C = O, N (H) S (O) 2, C = ON (H) or S (O) 2N (H); Y is N (R11), S, O, C (R12) = C (R13), N = C (R14) or C (R15) = N, or optionally substituted 5-7 membered carbocyclyl; R11 is hydrogen, (C1-10) alkyl, hydroxy (C1-10) alkyl -, (C1-10) alkyloxy, (C1-10) alkyl -S (O) m- (C1-10) alkylcarbonyl -, phenyl , amino, (C1-10) alkylamino or di ((C1-10) alkyl) amino; R12 is hydrogen, halogen, (C1-10) alkyl, (C2-10) alkenyl, C3-6 cycloalkyloxy (C3-10) cycloalkenyloxy, C3-6) cycloalkyl, (C3-10) cycloalkenyl, cycloalkyl ( C3-6) - [(C1-4) alkyl or (C2-4) alkenyl], (C3-6) cycloalkyl (C1-4) alkyloxy, hydroxy (C1-10) alkyl -, (C1-10) alkyloxy ), (C2-10) alkenyloxy, (C1-10) alkyl -S-, cyano, (C1-10) alkylcarbonyl -, phenyl or nitro; R13 is hydrogen, halogen or (C1) alkyl; R14 is hydrogen, halogen, (C1-4) alkyl, hydroxy (C1-3) alkyl -, (C1-3) alkyloxy, (C1-3) alkyl -S (O) m, cyano, (C1-2) alkylcarbonyl ) -, amino, (C1-3) alkylamino, di ((C1-3) alkyl) amino or nitro, with the proviso that the total number of atoms of C, N, O and S that are present in R14 does not exceed 4; R15 is hydrogen, halogen, (C1-10) alkyl, (C2-10) alkenyl, (C3-6) cycloalkyl (C3-6) cycloalkenyl, (C3-6) cycloalkyl - [(C1-4) alkyl or alkenyl (C2-4)], hydroxy (C1-10) alkyl -, cyano, (C1-10) alkylcarbonyl -, phenyl, amino [(C1-10) alkyl or (C2-10) alkenyl -] amino, [alkyl (C1-10) or (C2-10) alkenyl] ((C1-10) alkyl) amino or nitro; R21 is hydrogen when Y is C (R12) = C (R13), N = C (R14) or C (R15) = N, and is hydrogen, halogen, (C1-4) alkyl, hydroxy-(C1-3) alkyl ) -, (C1-3) alkyloxy, (C1-3) alkyl -S (O) m-, cyano, (C1-2) alkylcarbonyl,, amino, (C1-3) alkylamino, di ((C1-3) alkyl )) amino or nitro when Y is N (R11), S or O, with the proviso that the total number of atoms of C, N, O and S that are present in R21 does not exceed 4; R22 is hydrogen, halogen, (C1) alkyl when Y is C (R12) = C (R13), N = C (R14) or C (R15) = N, or is hydrogen, hydroxy-alkyl (C1-3) - , (C1-3) alkyloxy, (C1-3) alkyl -S (O) m-, cyano, (C1-2) alkylcarbonyl -, amino, (C1-3) alkylamino, di ((C1-3) alkyl) amino or nitro when Y is N (R11), S or O, with the proviso that the total number of atoms of C, N, O and S that are present in R22 does not exceed 4; R51 is COOH or CONH (R53); R53 is R55-SO2 or tetrazolyl; R55 is (C1-4) alkyl or phenyl optionally substituted with one or more same or different substituents chosen from the group consisting of halogen, (C1-4) alkyl, (C1-4) alkyloxy, (C1-4) alkyl - sulfonyl and cyano; and m is 0, 1 or 2; where all the phenyl groups herein may be independently of each other optionally substituted with one or more same or different substituents chosen from the group consisting of halogen, (C1-4) alkyl, (C1-4) alkyloxy, (C1-) alkylsulfonyl 4) and cyano; where all alkyl groups herein may be independently of one another optionally substituted with one or more fluorine atoms; or a stereoisomeric form thereof, a mixture of stereoisomeric forms thereof in any proportion or a physiologically acceptable salt thereof. |
| priorityDate | 2007-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.