http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-066760-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_24e76490bed88751680a5fef9bc73892 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 |
| filingDate | 2008-05-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-09-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-066760-A1 |
| titleOfInvention | HETEROARILO DERIVATIVES OF ANTIDEPRESSIVE BENZODIOXANOS HETEROCICLO-FUSIONADOS, PHARMACEUTICAL COMPOSITIONS, PROCESSES OF OBTAINING |
| abstract | Useful for the treatment of depression (which includes, but is not limited to, severe depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as pre-menstrual syndrome), attention deficit disorder (with and without hyperactivity), obsessive-compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor rubefaction, addiction to Cocaine and alcohol, sexual dysfunction and related diseases. Claim 1: A compound of formula (1): or a pharmaceutically acceptable salt of said compound; where: G is a carbon atom that has a hydrogen atom attached to it, where the carbon atom can have the R or S configuration; R1 is hydrogen, hydroxy, halo, cyano, carboxamido, carboalkoxy of 2 to 6 carbon atoms, trifluoromethyl, alkyl of 1 to 6 carbon atoms, alkanoyloxy of 2 to 6 carbon atoms, amino, mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms, alkanide of 2 to 6 carbon atoms, or alkanesulfonamido of 1 to 6 carbon atoms; the group X-Y1 is -N = C (R2) -C (R3) = N-, -N = C (R2) -C (R4) = CH-, -N = C (R2) -N = CH- or -N = C (R2) -O-; R2 and R3 are, independently, hydrogen, hydroxy, C1-12 alkoxy, halo, C1-6 alkyl, amino, or mono- or di-alkylamino in which each alkyl group has 1 to 6 carbon atoms; R4 is hydrogen or C1-6 alkyl; A is -Q1-Q2-; Q1 is -N (R8) -, (2) or (3) where: J is NH; k is 0 or 1; L1 is N or CH; L2 is N or CH; R6 is hydrogen or C1-12 alkyl; R8 is hydrogen, C1-12 alkyl, C4-20 alkylcycloalkyl or C3-8 cycloalkyl; n is 1.2 or 3; y is 1 or 2, with the proviso that when y is 2, n is 1; with the proviso that when k is 1, then L1 is CH; Q2 has the formula (4) or (5): where: each R6a and each R6b is independently hydrogen or C1-12 alkyl; each R7 is independently hydrogen or C1-12 alkyl; X1 is O, NH or - (CH2) v- where you see 1, 2, 3 or 4; R is 0.1, 2, 3 or 4; s is 0 or 1; t is 0, 1, 2 or 3; with the proviso that when Q2 has the formula (5) where X1 is 0Oo (CH2) v then Q is N (R8); B has the formula: (6) where: R10 is hydrogen, C1-12 alkyl or C4-20 alkylcycloalkyl, (CH2) x-cycloalkyl; L3 is C (= W ') - or CH2; W 'is O or S; W is O, CH2 or (7); Z is O, CH2 S or SO2; R11 is hydrogen, C1-12 alkyl, cyano or halogen; with the proviso that Z and W are not both O; and with the proviso that W is not O when Z is S or SO2. |
| priorityDate | 2007-05-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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