http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-066310-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e559abcd8f120b071dc1162360867ffa |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-653 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-90 |
| filingDate | 2008-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-066310-A1 |
| titleOfInvention | DERIVATIVES OF 4-AZA INDOL AND ITS USE AS FUNGICIDES |
| abstract | Process for the preparation of a compound of formula (1) and composition comprising it. Claim 1: A method of prevention and / or control of fungal infection in plants and / or plant propagation material comprising applying to the plants or plant propagation material an effective amount as a fungicide of a compound of the formula (1 ), where: X1 is N or CH; X2 is N or CR5; R1 and R2 are independently, (i) hydrogen, halogen, hydroxyl, cyano or nitro, (ii) optionally substituted alkyl, alkenyl or alkynyl, (iii) aryl, heteroaryl, cyclyl or optionally substituted heterocyclyl, or (iv) -C ( O) R10, -C (O) NR10R11, -C (S) NR10R11, -C (NOR10) R11, -C (O) OR10, -OR10, -SR10, -S (O) R10, -S (O) NR10R11, -S (O) 2R10, -NR10R11, -P (O) (OR10) (OR11) or -OP (O) (OR10) (OR11); R3 is: (i) hydrogen, hydroxyl, cyano or nitro, (ii) optionally substituted alkyl, alkenyl, alenyl, alkynyl or haloalkyl, (iii) optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl or heterocyclyl, or (iv) -C ( O) R12, -C (O) OR12, -OR12, -OC (O) R12, -S (O) 2R12 or -NR12R13; R4 is: (i) hydrogen, halogen, hydroxyl, cyano or nitro, (ii) optionally substituted alkenyl, alenyl, alkynyl or haloalkyl, (iii) optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl or (iv) -C (O) R14, -C (O) OR14 -C (NOR14) R15, -OR14, -SR14, -S (O) NR14R15, -S (O) 2R14 or -NR14R15; R5 is: (i) hydrogen, halogen, hydroxyl, cyano or nitro, (ii) optionally substituted alkyl, alkenyl or alkynyl, (iii) -C (O) R16, -C (O) OR16, -OR16, -SR16, - S (O) R16, -S (O) NR16R17, -S (O) 2R16 or -NR16R17; R6 is H, halogen, cyano, -C (O) OR18, -SR18, -NR18R19, -C (O) NR18R19, -N = CR20, -C (= NR18) NR19R20 or aryl, heteroaryl, cycloyl or optionally substituted heterocyclyl; R7 and R8 are independently hydrogen, halogen, hydroxyl, cyano, nitro, -NR21R22 or optionally substituted alkyl; R10, R11, R14, R15, R16 and R17 are independently hydrogen, halogen, hydroxy, cyano, nitro, optionally substituted alkyl, alkoxy, alkenyl or alkynyl, or optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl; R12 and R13 are independently hydrogen, halogen, hydroxyl, cyano, nitro, -NR21R22, optionally substituted alkyl, alkoxy, alkenyl or alkynyl, or optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl; R18 and R19 are independently, (i) hydrogen, (ii) optionally substituted alkyl, alkenyl or alkynyl, (iii) optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl, or (iv) -C (S) R23, -C (O) R23, -SO2R23, -C (O) OR23, -OR23 or -C (O) NR23R24; R20 is optionally substituted hydroxy, alkyl or alkoxy, -NR21R22 or -N = CR21R22; R21 and R22 are independently hydrogen, optionally substituted alkyl, alkenyl or alkynyl, cyclyl, heterocyclyl, aryl or heteroaryl or optionally substituted aralkyl or -C (O) OR25; R23 and R24 are independently hydrogen, hydroxy, optionally substituted alkyl, alkenyl or alkynyl, or optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl or aralkyl; and R25 is optionally substituted alkyl, alkenyl or alkynyl; and / or independently, (i) R1 and R2, (ii) R1 and R3 (iii) R2 and R3, (iv) R3 and R5, (v) R5 and R6, (vi) R5 and R18, (vii) R5 and R19, (viii) R14 and R15 and (ix) R18 and R19 form an optionally substituted aryl, heteroaryl, cyclyl or heterocyclyl group containing from 5 to 18 ring atoms; or a N-oxide salt thereof. Claim 19: A compound of the formula (1) as defined in any of claims 1 to 17, provided that (i) when X1 is CH, X2 is CR5 and R5 and R6 are both H, R4 is not 4-fluorphenyl (ii) the compound of the formula (1) is not: 3-phenyl-2-pyridin-4-yl-1H-pyrrolo [3,2-b) pyridine, 3- (3-chloro-4- fluor-phenyl) -2-pyridin-4-yl-1H-pyrrolo [3,2-b] pyridine, 3- (3-chloro-phenyl) -2-pyridin-4-yl-1H-pyrrolo [3,2 -b] pyridine, 3- (3-trifluor-phenyl) -2-pyridin-4-yl-1H-pyrrolo [3,2-b] pyridine, 3- (3-methoxy-phenyl) -2-pyridin-4 -yl-1H-pyrrolo [3,2-b) pyridine, 3- (2-methylphenyl) -2-pyridin-4-yl-1H-pyrrolo [3,2-b] pyridine, 3- (2-methoxyphenyl- 2-pyridin-4-yl-1H-pyrrolo [3,2-b] pyridine, 1-methyl-2-pyridin-4-yl-3- (3-trifluoromethyl-phenyl) -1H-pyrrolo [3,2- b] pyridine, 1-methyl-3- (3-chloro-4-fluorophenyl) -2-pyridin-4-yl-1H-pyrrolo [3,2-b] pyridine, 3- (4-fluorphenyl-2 - (2- (2-Hydroxyethyl-amino) -pyridin-4-i-1H-pyrrolo [3,2-b] pyridine, 3- (4-fluorphenyl) -2- (2- [HO (CH2) 2O ( CH2) 2NH] -pyridin-4-yl) -1H-pyrrolo [3,2-b] pyridin a, 3- (4-fluorophenyl) -2- (2- (2-methylamino-ethylamino) -pyridin-4-yl) -1H-pyrrolo [3,2-b] pyridine, 3- (4-fluorphenyl-2 - (2- (3-Methoxy-propyl-amino) -pyridin-4-yl) -1H-pyrrolo [3,2-b] pyridine, 3- (4-fluorphenyl) -2- (2-n-propylamino- pyridin-4-yl) -1H-pyrrolo [3,2-b] pyridine, 3- (4-fluorophenyl) -2- (2- (3-hydroxy-propyl-amino) -pyridin-4-yl) -1H -pyrrolo [3,2-b] pyridine, 3- (4-fluorphenyl-2- (2-methylamino-pyridin-4-yl) -1 H -pyrrolo [3,2-b] pyridine or 3- (4-fluorphenyl) ) -2- (2-acetylaminopyridin-4-yl) -1H-pyrrolo [3,2-b] pyridine. Claim 24: A compound of the formula (1) as defined in the method of any of claims 1 to 17 for the treatment of fungal infection in humans or animals. |
| priorityDate | 2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 48.