http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-066267-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28e3113097dd6d28720572e47f2f2407 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 |
| filingDate | 2008-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd309351b21a694cd28a4b119b306b4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56d5197801c1534080d66c91ec880fca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9856e5396ec55b642d1bf9f1d070d1b0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4e6e94ca2a80843c045b71ded8450d89 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89414959ff5042ad056970b6a5c397cb |
| publicationDate | 2009-08-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-066267-A1 |
| titleOfInvention | PIPERIDINE DERIVATIVES AS AN TAGIQUININE RECEPTOR ANTAGONISTS |
| abstract | Claim 1: A compound characterized by the formula: wherein it is: (1) carbamoylmethyl, (2) methylsulfonylethylcarbonyl, (3) aminosulfonylpropylcarbonyl, (4) phenylsulfonylethylcarbonyl, (5) pyridin-2-ylcarbonyl, (6) 5-methoxycarbonylpyridine- 2-ylcarbonyl, (7) 5-hydroxypyridin-2-ylcarbonyl, (8) 6-hydroxypyridin-2-ylcarbonyl, (9) 5-bromopyridin-2-ylcarbonyl, (10) 6-methylpyridin-2-ylcarbonyl, (11) ) 5-carbamoylpyridin-2-ylcarbonyl, (12) 2-aminopyridin-5-ylcarbonyl, (13) 2-acetylaminopyridin-5-ylcarbonyl, (14) pyridin-3-ylcarbonyl, (15) pyrazin-2-ylcarbonyl, ( 16) pyrimidin-5-ylcarbonyl, (17) 2-aminopyrimidin-5-ylcarbonyl, (18) 2-acetylaminopyrimidin-5-ylcarbonyl, (19) 2-methoxycarbonylaminopyrimidin-5-ylcarbonyl, (20) azetidin-3-ylcarbonyl, (21) 1-tert-butoxycarbonylazetidin-3-ylcarbonyl, (22) 1- (1-hydroxy-1-methylethylcarbonyl) azetidin-3-ylcarbonyl, (23) 1-hydroxymethylcarbonylazetidine-3-ylcarbonyl, (24) adamantan-1 -ylcarbonyl, (25) 1-carbamoyl-1-methyl ethylcarbonyl, (26) dimethylaminomethylcarbonyl, (27) 1,2,3,4-tetrahydropyrimidin2,4-dion-1-ylmethylcarbonyl, (28) 2,3,5,6-tetrahydropyrimidin2, 6-dion-4-ylmethylcarbonyl, (29) 1-hydroxymethylcarbonylpiperidine -4-ylcarbonyl, (30) 1-ethoxycarbonylpiperidin-4-ylcarbonyl, (31) 1-isopropoxycarbonylpiperidin-4-ylcarbonyl, (32) 1-cyclopropylsulfonylpiperidin-4-ylcarbonyl, (33) 1- (1-hydroxyethylcarbonyl) piperidine 4-ylcarbonyl, (34) 5,5-dimethyloxazolidin2,4-dion-3-ylmethylcarbonyl, (35) 5,5-dimethyloxazolidin2,4-dion-3-ylethylcarbonyl, (36) oxazolidin2,4-dion-3-ylmethylcarbonyl , (37) 1- (2-Hydroxy-2-methylpropylcarbonyl) piperidin-4-ylcarbonyl, (38) 3-methylimidazolidin4,4-dimethyl-2,5-dion-1-ylmethylcarbonyl, (39) 4,4-dimethylpiperidin2 , 6-dion-1-ylmethylcarbonyl, (40) morpholin-2,6-dion-1-ylmethylcarbonyl, (41) imidazol-2-ylcarbonyl, (42) imidazol-4-ylcarbonyl, (43) 5,5-dimethyloxazolidin2 , 4-dion-3-ylethyl, (44) 5,5-dimethyloxazolidin2,4-dion-3-ylpropyl, (45) 6-chloropyridazin-3-yl, (46) 6-acetylaminopyridazin-3-yl, (47 ) 5-methyl-1,3,4-thiadiazol-2-yl, (48) 5-acetylaminopyridin-2-yl, (49) 4-nitrotiazol-2-yl, (50) 2,2,2-trichloroethoxycarbonyl, ( 51) ethylsulfonyl, (52) cyclopropylsulfonyl, (53) isobutylsulfonyl, (54) 1-benzyloxycarbonylpiperidin-4-ylsulfonyl, (55) 1-hidroximetilcarbonilpiperidin-4-ylsulfonyl, (56) etoxietilsulfonilo, (57) hydroxyethylsulfonyl, (58) morpholin -1-ylethylsulfonyl, (59) 5,5-dimethyloxazolidin2,4-dion-3-ylethylsulfonyl, (60) indole-6-ylcarbonyl, (61) benzimidazol-6-ylcarbonyl, (62) benzothiazol-2-ylcarbonyl, ( 63) thiazol-2-ylcarbonyl, (64) cyclopropylaminocarbonylmethyl, (65) 4-hydroxypiperidin-1-ylcarbonylmethyl, (66) 1-tert-butoxycarbonylpiperidine-4-yl, (67) piperidin-4-yl, (68) 1 -isopropoxycarbonylpiperidin-4-yl, (69) 1-aminocarbonylcarbonylpiperidin-4-yl, (70) 1-carbamoylpiperidin-4-yl, (71) 1-hydroxymethylcarbonylpiperidin-4-yl, (72) 1- (1-hydroxy- 1-methyl ethylcarbonyl) piperidin-4-yl, (73) 1-carbamoyl-1-methyl ethyl, (74) 1-acetylpiperidin-4-ylmethyl, (75) 4-carbamoyl piperidin-1-ylcarbonylmethyl, (76) 3-oxopiperazin-1-ylcarbonylmethyl, (77) methoxycarbonylethyl, (78) carbamoylethyl, (79) cyclopenten-3-on-1-yl, (80) 4,4-dimethylcyclohexen-3 -on-1-yl, (81) 2-hydroxy-1-methyl ethyl, (82) 1-carbamoylethyl, (83) 2-methylsulfonyl-1-methyl ethyl, (84) 3-hydroxy-3-methylbutyl, (85) 4-acetylaminobenzoyl, (86) 4-cyanobenzoyl, (87) 4-carbamoylbenzoyl, (88) 10-canphosulfonyl, (89) 6-chloropyridazin-3-yl, (90) pyridin-2-yl, (91) 1- (1-hydroxy-1-methyl ethylcarbonyl) piperidin-4-ylcarbonyl, (92) 1-methoxymethylcarbonylpiperidin-4-ylcarbonyl, (93) 1-aminocarbonylpiperidin-4-ylcarbonyl (94) 1-aminocarbonylcarbonylpiperidin-4-ylcarbonyl (95) -isopropylpiperidin-4-ylcarbonyl, (96) 1- (1-hydroxycyclopropylcarbonyl) piperidin-4-ylcarbonyl, (97) tetrazol-5-ylmethylcarbonyl, (98) 1- (tetrazol-1-ylmethylcarbonyl) piperidin-4-ylcarbonyl, (99) 1- (acetylaminomethylcarbonyl) piperidin-4-ylcarbonyl, (100) 2-hydroxyethylcarbonyl, (101) thiomorpholin-1,1-dioxide-4-ylmethylcarbonyl, (102) d imethylaminosulfonyl, (103) 4-acetylaminophenylsulfonyl, (104) pyridin-2-ylsulfonyl, (105) pyridin-3-ylsulfonyl, (106) 6-chloropyridin-3-ylsulfonyl, (107) 6- (morpholin-1-yl) pyridin-3-ylsulfonyl, (108) piperidin-3-ylcarbonyl (109) 1-tert-butoxycarbonylpiperidin-3-ylcarbonyl (110) 1-methoxycarbonylpiperidin-3-ylcarbonyl, (111) 1-acetylpiperidin-3-ylcarbonyl, (112) ) 1-Hydroxymethylcarbonylpiperidin-3-ylcarbonyl, (113) 1- (1-hydroxy-1-methyl ethylcarbonyl) piperidin-3-ylcarbonyl, (114) 1-methylsulfonylmethylcarbonylpiperidine-3-ylcarbonyl, (115) 1-methylsulfonyl-piperidyl-3-ylcarbonyl , (116) 1-aminocarbonylcarbonylpiperidin-3-ylcarbonyl, (117) 4-hydroxymethylcarbonylaminocyclohexane-1-ylcarbonyl, (118) 4-methoxymethylcarbonylaminocyclohexan-1-ylcarbonyl, (119) 4-aminocarbonylaminocyclohexan-1-ylcarbonyl, 1-ylcarbonyl, 1-120 aminocarbonylcarbonylaminocyclohexan-1-ylcarbonyl, (121) 4-methylsulfonylaminocyclohexan-1-ylcarbonyl, (122) tetrahydrofuran-3-ylcarbonyl, (123) thiazolidin-2-on-4-ylcarbonyl, (124) 1-tert-butoxycarbonylpyrrolidin-3-ylcarbonyl, (125) 1-methoxycarbonylpyrrolidin-3-ylcarbonyl or (126) 1-hydroxymethylcarbonylpyrrolidin-3-ylcarbonyl; R2 is methyl or cyclopropyl; R3 is a hydrogen or methyl atom; R4 is a chlorine or trifluoromethyl atom; R5 is a chlorine or trifluoromethyl atom; and a group represented by formula 2 is a group represented by formula 3 wherein R6 is a hydrogen, methyl, ethyl or isopropyl atom; R7 is a hydrogen, methyl or chlorine atom; and R8 is a hydrogen atom, a fluorine atom, a chlorine or methyl atom; or 3-methylthiophene-2-yl; or a salt thereof. |
| priorityDate | 2007-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.