http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-066169-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 |
| filingDate | 2008-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-066169-A1 |
| titleOfInvention | DERIVATIVES OF BENZO-IMIDAZOLES, USEFUL FOR DISORDERS ASSOCIATED WITH THE ACTIVITY OF DGAT |
| abstract | The compounds herein are useful for the treatment of conditions or disorders associated with the activity of DGAT1 in animals, in particular in humans. Claim 1: A compound having the following structure: AQBCD wherein: A is a substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, optionally substituted amino, substituted or unsubstituted aryl, substituted or unsubstituted or substituted hetero-aryl or unsubstituted heterocyclyl; Q is a divalent or trivalent five-membered heterocycle or hetero-aryl; B is a substituted or unsubstituted divalent hetero-aryl group selected from one of the following groups of formulas (2) wherein: X1 and X2 'are independently selected from O, NH, NR9 or S, where R9 is selected from lower alkyl, lower alkyl-amino, lower alkoxy-alkyl, lower hydroxyl-alkyl, X1 ', X2, X3 and X4 are independently selected from N, or CH, C is: formula (3) wherein : R1, is selected from hydrogen, cyano, lower alkyl sulfonyl amino, alkanoyl amino, halogen, lower alkyl, trifluoro methyl, lower alkoxy, lower alkyl amino, lower dialkyl amino, and NO2, R ' 1, R2 and R2 are independently selected from hydrogen, halogen, trifluoro-methyl, aryloxy, lower alkyl, lower alkoxy, lower alkyl-amino, lower dialkyl-amino, and NO2, or C may also be an aryl group or substituted or unsubstituted bicyclic hetero-aryl, D is selected from hydrogen , halogen, hydroxyl, cyano, alkanoyl-amino, carboxyl, carbamoyl, -O-L2-E, -S-L2-E ', -C (O) -O-L2-E, -L2-Eö, and -NR6 -L2-E ', L2 is - (CH2) n' - (CR5R5 ') p' - (CH2) m'-; E is alkyl, acyl, alkoxycarbonyl, phosphonic acid, phosphonate, cycloalkoxycarbonyl, aryloxycarbonyl, heterocyclyloxycarbonyl, carboxyl, carbamoyl, sulfonyl, -SO2-OH, sulfamoyl, sulfonylcarbamoyl, sulfonyloxy, sulfonamido, -C (O ) -OR-PRO, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted hetero-aryl, and when n '+ m' + p 'is equal to zero, E is not sulfonyloxy or sulfonamido, E' is alkyl , acyl, alkoxycarbonyl, cycloalkoxycarbonyl, aryloxycarbonyl, heterocyclyloxycarbonyl, carboxyl, carbamoyl, sulfonylcarbamoyl, sulfonyl, -SO2-OH, sulfamoyl, sulfonamido, phosphonic acid, phosphonate, sulfonyloxy, -C (O) -OR-PRO, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted hetero-aryl, and when n '+ m' + p 'is equal to zero, E' is not sulfamoyl, sulfonamido, phosphonic acid, phosphonate , or sulfonyloxy, Eö is alkyl, acyl, alkoxycarbonyl, phosphonic acid, phosphonate, cycloalkoxycarbonyl, aryloxycarbonyl, heterocyclyloxycarbonyl, carboxyl, carbamoyl, sulfonyl, sulfamoyl, sulfonyloxy, sulfonamido, -SO2-OH, sulfonylcarbamoyl, -C (O) -OR-PRO, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted hetero-aryl, m ', n' and p 'are, independently of each other, an integer from 0 to 4, m' + n '+ p' is between 0 and 12, R5 and R5 'are, independently of each other, hydrogen, halogen, hydroxyl, lower alkoxy, or inner alkyl, or R5 and R5' join together to form a spiro residue of the formula (4) wherein: X 'is NRx, O, S or CRx'Rxö, r 'and s' are, independently of each other, zero or an integer from 1 to 3, Rx is hydrogen or lower alkyl, Rx' is hydrogen, halogen, hydroxyl, alkoxy, or lower alkyl, Rxö is hydrogen or lower alkyl; or a stereoisomer, enantiomer, or tautomer thereof, a pharmaceutically acceptable salt thereof, or a pro-drug thereof. |
| priorityDate | 2007-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 51.