http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065965-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a910d33c239980f3a705e312c5bad6a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4353 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D217-26 |
| filingDate | 2008-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_149c4ce5f36671eb40bddb0b20aae185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d54b7ba9e61a0f4f1d56da6d37bd4a0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689cdc35155faaab34927ad5d5e89d99 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4c66ae5d901ecd0d9a620f4986f38a4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e80205168d124054d8022e159e81480e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfea98eae400db37de241bb0d265d0b3 |
| publicationDate | 2009-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065965-A1 |
| titleOfInvention | DERIVATIVES OF ISOQUINOLINE AND ITS USE AGAINST RESPIRATORY DISEASES. |
| abstract | Processes for their preparation, pharmaceutical compositions containing them and their use in therapies. Claim 1: A compound characterized in that it responds to formula (1) wherein: R1 is selected from H, (C1-6) alkyl, (C2-6) alkenyl, (C3-6) alkynyl, (VH2) aX-Ar and (CR101R102) aX-Ar where said (C1-6) alkyl is optionally substituted with 1, 2 or 3 groups independently selected from - (C1-6) alkoxy, -halo, -OH, -heterocycloalkyl, (C3-7 ) cycloalkyl, and -NR8R9; R2 and R3 are independently selected from H, halo, (C1-6) alkyl, (C1-6) alkoxy and (CH2) d-Y; wherein said (C1-6) alkyl is optionally substituted with 1, 2 or 3 groups independently selected from - (C1-6) alkoxy, -halo and -OH; and where (C1-6) alkoxy is optionally substituted with 1, 2 or 3 groups independently selected from -halo and -OH; and with the proviso that when R2 is (CH2) d-Y, R3 is selected from H, halo, (C1-6) alkyl and (C1-6) alkoxy; and with the proviso that when R3 is (CH2) d-Y, R2 is selected from H, halo, (C1-6) alkyl and (C1-6) alkoxy; R4 and R5 are independently selected from H, (C1-6) alkyl, (C1-6) alkoxy, halo, CF3, and CN; R6 is selected from (C1-6) alkyl, (C1-6) alkoxy, (C3-7) cycloalkyl, aryl, heteroaryl and OH, wherein said (C1-6) alkyl group, (C1-6) alkoxy, (C3 -7) cycloalkyl, aryl or heteroaryl may be substituted with 1 or more halo atoms; R7 is selected from H, (C1-6) alkyl, (C1-6) alkoxy and halo; Ar is an aryl or heteroaryl ring optionally substituted with 1, 2 or 3 groups independently selected from - (C1-6) alkyl, - (C2-6) alkenyl, - (C3-6) alkynyl, (CH2) eO- (C1-6) alkyl, - (CH2) eS (O) f- (C1-6) alkyl, - (CH2) eN (R10) - (C1-6) alkyl, - (CH2) eZ- (C1-6 ) alkyl, -O-heterocycloalkyl, -S (O) b-heterocycloalkyl, -N (R11) -heterocycloalkyl, -CN, -OH, -halo, -phenyl, -heterocycloalkyl, - (C3-7) cycloalkyl, -C (O) NR8R9, -NR8R9, -C (O) OH and C (O) NR10SO2- (C1-6) alkyl, where in each occurrence (C1-6) alkyl is optionally independently substituted with 1, 2 or 3 groups independently selected from -halo, -OH, - (C1-6) alkoxy, -NR13R13 and heterocycloalkyl; X is selected from a simple link, O, NR14 and S (O) g; Y is selected from heterocycloalkyl, O-heterocycloalkyl, O- (CH2) h-NR16R17, NR18- (CH2) h-NR16R17, S (O) j-heterocycloalkyl, S (O) j- (CH2) h- NR16R17, NR16R17 , NR15C (O) R16, NR15SO2R16, C (O) NR16R17, OC (O) NR16R17, OC (O) R16, C (O) OR16 and NR15C (O) OR16; Z is selected from C (O) N (R18), N (R18) C (O), C (O) O, OC (O), SO2N (R18), N (R18) SO2, OC (O) N ( R18), N (R18) C (O) O, and OC (O) O; R8 and R9 are independently selected from H and (C1-6) alkyl, wherein said (C1-6) alkyl is optionally substituted with 1, 2 or 3 groups independently selected from - (C1-6) alkoxy, -halo , -OH and NR19R20; or R8 and R9 together with the nitrogen atom to which they are attached form a ring of between 3 and 7 members, optionally containing an additional heteroatom selected from NR21, S and O; and optionally containing, if possible, 1 or 2 double bonds; wherein said ring is optionally substituted on carbon with 1 or 2 substituents independently selected from - (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, OH, -CN, halo and -NR19R20; R12 and R13 are independently selected from H and (C1-6) alkyl where said (C1-6) alkyl is optionally substituted with - (C1-6) alkoxy, -OH, -halo, - (C3-7) cycloalkyl and -NR22R23; or R12 and R13 together with the nitrogen atom to which they are attached form a ring of between 3 and 7 members, optionally containing an additional heteroatom selected from NR24, S and O; and optionally containing, if possible, 1 or 2 double bonds; wherein said ring is optionally substituted on carbon with 1 or 2 substituents independently selected from - (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CNM, halo and -NR22R23 ; R16 is selected from H, (C1-6) alkyl and heterocycloalkyl, wherein said (C1-6) alkyl is optionally substituted with - (C1-6) alkoxy, -OH, -halo, - (C3-7) cycloalkyl and - NR25R26; R17 is selected from H and (C1-6) alkyl; or R16 and R17 together with the nitrogen atom to which they are attached form a ring of between 3 and 7 members, optionally containing an additional heteroatom selected from NR27, S and O; and optionally containing, if possible, 1 or 2 double bonds; wherein said ring is optionally substituted on carbon with 1 or 2 substituents independently selected from - (C1-6) alkyl, (C1-6) alkoxy, (C2 -6) alkenyl, -OH, -CN, halo and -NR25R26, wherein said - (C1-6) alkyl is optionally substituted with -OH. R25 and R26 are independently selected from H and (C1-6) alkyl where (C1-6) alkyl is optionally substituted with - (C1-6) alkoxy, -OH, -halo, - (C3-7) cycloalkyl and -NR22R23; or R25 together with the alkaline nitrogen atom are attached form a ring of between 3 and 7 members, and optionally containing an additional heteroatom selected from NR24, S and O; and optionally containing, if possible, 1 or 2 double bonds; wherein said ring is optionally substituted on carbon with 1 or 2 substituents independently selected from - (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CN, halo and -NR22R23; R27 is selected from H, (C1-6) alkyl and heterocycloalkyl, where (C1-6) alkyl is optionally substituted with a substituent selected from -OH, -halo and -NR22R23; R10, R11, R14, R15, R18, R19, R20, R21, R22, R23 and R24 are independently selected from H and (C1-6) alkyl; a is selected from 0, 1, 2, 3, 4, 5 and 6; d, e and h are independently selected from 0, 1, 2 and 3; b, f, g and j are independently selected from 0, 1 and 2; heterocycloalkyl in a 3- to 7-membered non-aromatic cyclic ring linked by C, containing between 1 and 2 NR28 atoms, or an NR28 atom and an S or O atom, or an S atom, or an O atom ; which optionally contains, if possible, 1 or 2 double bonds; which, unless otherwise specified, may be optionally substituted with between 1 and 3 substituents independently selected from (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CN, halo and -NR29R30; heteroaryl is an aromatic ring of 5, 6, 9 or 10 members, containing between 1 and 2 N atoms and, optionally, an NR31 atom, or an NR31 atom and an S or O atom, or an S atom, or an atom of O; which, unless otherwise specified, may be optionally substituted with 1-3 substituents independently selected from (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CN, halo and -NR38R39; cycloalkyl is a non-aromatic carbocyclic ring containing the indicated number of carbon atoms, optionally containing, if possible, up to 3 double bonds; which unless otherwise specified, may be optionally substituted with between 1 and 3 substituents independently selected from (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CN, halo and -NR34R35; aryl is an aromatic ring containing 6 to 10 carbon atoms; which unless otherwise specified, may be optionally substituted with between 1 and 3 substituents independently selected from (C1-6) alkyl, (C1-6) alkoxy, (C2-6) alkenyl, -OH, -CN, halo and -NR36R37; R28 and R31 are independently selected from each other from H, (C1-6) alkyl and -C (O) O- (C1-6) alkyl, wherein said (C1-6) alkyl may be optionally substituted with (C1- 6) alkoxy, -OH, halo, (C3-7) cycloalkyl and -NR32R33; R29, R30, R32 and R33 are independently selected from each other between H and (C1-6) alkyl; R34, R35, R36, R37, R38 and R39 are independently selected from each other from H, and (C1-6) alkyl. R101 is (C1-6) alkyl; R102 is H or (C1-6) alkyl; or a salt or an N-oxide acceptable for pharmaceutical use thereof. |
| priorityDate | 2007-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 31.