http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065854-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-537 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 |
| filingDate | 2008-03-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ebd345b234d257dabf6e8d3c9aa8f57 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_db528ded7154ba1b34f485ca628f3aff |
| publicationDate | 2009-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065854-A1 |
| titleOfInvention | DERIVATIVES OF 1-OXA-3,9-DIAZA-ESPIRO [5.5] UNDECAN-2-ONA, MEDICINES CONTAINING THEM AND USES AS ANTI HIV AGENTS, AMONG OTHERS. |
| abstract | A compound of the formula I, wherein R is (a) C3-6 cycloalkyl, said cycloalkyl is optionally substituted one to three times by moieties independently selected from the group consisting of hydroxy, C1-3 alkyl, oxo, halogen, C1-6-oximino alkoxy and C1-6 alkoxy-C1-6 alkoxy; (b) (C3-6 cycloalkyl) -C1-3alkyl, said cycloalkyl is optionally substituted one to three times by moieties independently selected from the group consisting of hydroxy, C1-3 alkyl, oxo, halogen, C1-6 alkoxy -oximino and C1-6 alkoxy-C1-6 alkoxy, with the proviso that said (C3-6 cycloalkyl) -C1-3alkyl is not 4,4-difluorocyclohexylmethyl or 1-hydroxyl-cyclohexylmethyl, (c ) the compound of the formula (2) in which R6 is hydrogen or halogen; (d) the compound of the formula (3); (e) the compound of the formula (4), (f) the compound of the formula (5) in which m is 0 or 2; (g) heteroaryl, heteroaryl-C1-3 alkyl, phenylalkyl C1-3 in which said heteroaryl is pyridine, pyrimidine, pyrazine or pyridazine and said heteroaryl or said phenyl is independently substituted by 1-3 substituents independently selected from C1 alkyl -3, halogen, C1-6 alkoxy, cyano and nitro (h) C1-3 haloalkyl (i) the compound of the formula (6), (j) the compound of the formula (7), (k) the compound of the formula (8), (m) the compound of the formula (9); R2 is C1-6 alkyl; R3 is hydrogen or C1-3 alkyl; R4 is chosen from the group consisting of (a) - (i) and (j): (a) 4,6-dimethyl-pyrimidin-5-yl; (b) 4,6-dimethyl-2-trifluoromethyl-pyrimidin-5-yl; (c) 2,4-dimethyl-pyridin-3-yl; (d) 2,4-dimethyl-1-oxy-pyridin-3-yl 6-cyano-2,4-dimethyl-pyridin-3-yl; (f) 2,4-dimethyl-6-oxo-6H-pyran-3-yl (g) 2,4-dimethyl-6-oxo-1,6-dihydro-pyridin-3-yl; (h) 1,2,4-trimethyl-6-oxo-1,6-dihydro-pyridin-3-yl; (i) 3,5-dimethyl-1-oxy-1 H -pyrazol-4-yl; and (j) 5-cyano-2,4-dimethyl-1H-pyrrole-3-yl; or (k) 3-methyl-5-trifluoromethyl-isoxasol-4-yl (1) 3,5-dimethyl-1-hydroxy-pyrazol-4-yl; R 6 is C 1-6 acyl, (C 1-6 alkoxy) -carbonyl, (C 1-6 alkyl) -SO, C 1-6 haloalkyl, C 3-6 cycloalkyl, oxetanyl, tetrahydrofuranyl or tetrahydropyranyl and n is 0-3; p is the number 1 or 3; or a pharmaceutically acceptable acid addition salt thereof. |
| priorityDate | 2007-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 35.