http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065708-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2592fdd67689273a0c7caed0d4c2e360 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D407-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 |
| filingDate | 2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e70c227fe2d83d90ad76c32b7956034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_77fb0a9f230fb65b30a9ac36834be0fb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6cdf9f9e28c03971dec4470c2941caa4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_823fedf74184d1da189b53e08b6a463f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fee638e8345df400afdca943f2a1be18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d205f898bbcc141d6f2b784ebf4972c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba26b9546592179ffbb8044d1a64c869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44ed36bd26504bd1c2e72d4075bf010 |
| publicationDate | 2009-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065708-A1 |
| titleOfInvention | USEFUL PIPERIDINONES FOR THE TREATMENT OF INFLAMMATION |
| abstract | Claim 1: A compound, characterized in that it is of formula (1), m represents 0, 1, 2, 3, 4 or 5; n represents 0, 1, 2 or 3; R1 represents hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl (where said last three groups are optionally substituted with one or more substituents selected from X1), -A1-Tz-B1, -A1a-N (R9) R10, -A1b-OR9, -A1c-C (O) R9, -A1d-C (O) OR9 or -A1e-C (O) N (R9) R10; R2 represents hydrogen, -OR4, C1-12 alkyl, C2-12 alkenyl or C2-12 alkynyl, wherein said last three groups are optionally substituted with one or more substituents that are selected from X1; or R1 and R2 together = C (R9) R10; R3 represents hydrogen, -OR4, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl (where said last three groups are optionally substituted with one or more substituents that are selected from X2) or -A2-B2; each R4 independently represents hydrogen, -R8-OR9, -R8C (O) OR9, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl (where said last three groups are optionally substituted with one or more substituents selected from X3) and / or -A3-B3; R5 represents hydrogen, -A4-B4, -C (O) R9, -C (O) OR10, C1-12 alkyl, C2-12 alkenyl or C2-12 alkynyl, wherein said last three groups are optionally substituted with one or more substituents that are selected from X4; each R6 independently represents halo, -R11-OR9, -R11-CN, -R11-NO2, -R11-C (O) OR9, -R11-N (R9) R10, -R11-C (O) N (R9) R10, -R11N (Rw3) C (O) R9, -R11-N (Rw3) C (O) N (R9) R10, -R11-N (Rw3) S (O) tR9x, -R11N (Rw3) S ( O) tOR9x, -R11-OC (O) R9, -R11-OC (O) N (R9) R10, -R11-OS (O) tR9x, -R11-S (O) pR9, -R11-S (O ) tN (Rw3) R9, -R11-S (O) tOR9, -R11-Si (R16) 3, C1-12 alkyl, C1-12 alkenyl, C1-12 alkynyl C3-15 cycloalkyl and / or heterocyclyl where said last five groups are optionally substituted with one or more substituents that are selected from X5; or any pair of R6 groups, or R2 and any R6 group, can be linked together to form an additional ring, which is formed by either the two relevant groups that are linked together by a direct bond or by a C1- alkylene 5; each R7 independently represents halo, -R11-OR9, -R11-CN, -R11-NO2, -R11-C (O) OR9, -R11-N (R9) R10, -R11-C (O) N (R9) R10, -R11N (Rw3) C (O) R9, -R11-N (Rw3) C (O) N (R9) R10, -R11-N (Rw3) S (O) tR9x, -R11N (Rw3) S ( O) tOR9x, -R11-OC (O) R9, -R11-OC (O) N (R9) R10, -R11-OS (O) tR9x, -R11-S (O) pR9, -R11-S (O ) tN (Rw3) R9, -R11-S (O) tOR9, -R11-Si (R16) 3, C1-12 alkyl, C1-12 alkenyl, C1-12 alkynyl C3-15 cycloalkyl and / or heterocyclyl where said last five groups are optionally substituted with one or more substituents that are selected from X5; Tz represents a direct union, -N (Rw1) - or -C (O) N (Rw2) -; each R9x independently represents C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl (where said last three groups are optionally substituted with one or more substituents selected from X6), -A5-O-A6 and / or -A7 -B7; each R9, R10, Rw1, Rw2 and Rw3 independently represent hydrogen, C1-12 alkyl, C2-12 alkenyl, C2-12 alkynyl (where said last three groups are optionally substituted with one or more substituents selected from X6), - A5-O-A6 and / or -A7-B7; or R9 and R10, together with the carbon or nitrogen atom to which both are attached, can be linked together to form a cycloalkyl or heterocyclyl group (of which both are optionally substituted with one or more substituents that are selected from Z1a ) or an aryl or heteroaryl group (of which both are optionally substituted with one or more substituents that are selected from Z1b); and each R11 independently represents a direct union or R8; A1, A1a, A1b, A1c, A1d, A1e, A4 and A5 independently represent C1-12 alkylene, C2-12 alkenylene or C2-12 alkynylene, where said last three groups are optionally substituted with one or more substituents that are selected from X7 ; A2, A3 and A7 independently represent a direct bond, C1-12 alkylene, C2-12 alkenylene or C2-12 alkynylene, where said last three groups are optionally substituted with one or more substituents that are selected from X8; A6 represents C1-12 alkyl, C2-12 alkenyl or C2-12 alkynyl, all of which are optionally substituted with one or more substituents that are selected from X9; each R8 independently represents C1-12 alkylene, C2-12 alkenylene or C2-12 alkynylene, all of which are optionally substituted with one or more substituents that are selected from X10; B1 represents heteroaryl (optionally substituted with one or more substituents that are selected from Z2a) or heterocyclyl (optionally substituted with one or more substituents that are selected from Z2b), where when B1 represents a polycyclic heteroaryl group, then the junction point of B1 al Tz is through a heterocyclyl or heteroaromatic ring of the polycycle; B2, B3 and B7 independently represent aryl (optionally substituted with one or more substituents selected from Y1), cycloalkyl, such as C3-15 cycloalkyl, (where said cycloalkyl group is optionally substituted with one or more substituents selected from Z3), heterocyclyl (optionally substituted with one or more substituents selected from Z4a) or heteroaryl (optionally substituted with one or more substituents selected from Z4b); B4 represents aryl optionally substituted with one or more substituents that are selected from Y2; X1 represents G1, C3-15 cycloalkyl (optionally substituted with one or more T2 substituents), heterocyclyl (optionally substituted with one or more T3 substituents), heteroaryl (optionally substituted with one or more T4 substituents), = O, Si (R16) 3, -OR14, -OC (O) -R14, -N (R14) 2, -C (O) R14, -C (O) OR14, -C (O) N (R14) 2, -N (R14) C (O) OR16, -N (R14) C (O) R16, -N (R14) S (O) tR16, -S (O) tOR16, -S (O) p16, -S (O) tN (R14 ) 2, -N (R14) C (O) N (R14) 2, -N (R14) S (O) tOR16, -OC (O) N (R14) 2 and / or -OS (O) tR9x; X2, X3, X4, X5, X6, X7, X8, X9 and X10 independently represent G1, aryl (optionally substituted with one or more substituents T1), C3-15 cycloalkyl (optionally substituted with one or more substituents T2), heterocyclyl ( optionally substituted with one or more substituents T3), heteroaryl (optionally substituted with one or more substituents T4), = O, Si (R16) 3, -OR14, -OC (O) -R14, -N (R14) 2, - C (O) R14, -C (O) OR14, -C (O) N (R14) 2, -N (R14) C (O) OR16, -N (R14) C (O) R16, -N (R14 ) S (O) tR16, -S (O) tOR16, -S (O) p16, -S (O) tN (R14) 2, -N (R14) C (O) N (R14) 2, -N ( R14) S (O) tOR16, -OC (O) N (R14) 2 and / or -OS (O) tR9x; Y1 and Y2 independently represent -Ax-By, G1, G2, -R15-OR17-N (R14) 2 and / or -R15-O-R17-N (R14) S (O) tR16; Z1a, Z1b, Z2a, Z2b, Z3, Z4a and Z4b independently represent G1, = O, = S, -Ax-By and / or G2; G1 represents C1-12 alkyl (optionally substituted with one or more substituents that are selected from T5), C2-12 alkenyl, C2-12 alkynyl (wherein said last two groups are optionally substituted with one or more substituents that are selected from T6) , halo, -CN, -NO2 or = O; G2 represents -Ax-Bx, R15-OR14, -R15-OC (O) -R14, -R15-N (R14) 2, -R15-C (O) R14, -R15-C (O) OR14, -R15 -C (O) N (R14) 2, -R15-N (R14) C (O) OR16, -R15-N (R14) C (O) R16, -R15-N (R14) S (O) tR16, -R15-S (O) tOR16, -R15-S (O) pR16 and / or -R15-S (O) tN (R14) 2; Ax represents a direct bond or C1-12 alkylene optionally substituted with one or more halo substituents o = O; Bx represents aryl or heteroaryl, wherein said groups are optionally substituted with one or more substituents that are selected from T7 and T8, respectively; By represents cycloalkyl or heterocyclyl, of which both are optionally substituted with one or more substituents that are selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl (where said last three groups are optionally substituted with one or more halo substituents), -OCH3, -OCHF2, -OCF3 and / or = O; T1, T4, T5, T6, T7 and T8 independently represent halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl (where said last three groups are optionally substituted with one or more substituents that are selected from Qx1), -OH, -O-C1-6 alkyl, -O-C2-6 alkenyl, -O-C2-6 alkynyl (where said last three groups are optionally substituted with one or more substituents that are selected from Qx2), -N ( Rw) 2, -NO2 and / or -CN; and / or T5 and T6 as an alternative or additionally may represent = O; T2 and T3 independently represent halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl (where said last three groups are optionally substituted with halo), -OCH3, -OCHF2, -OCF3 and / or = O; Qx1 and Qx2 independently represent halo, -OCH3, -OCHF2, -OCF3, -N (Rw) 2 and / or = O; each Rw independently represents hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, wherein said last three groups are optionally substituted with one or more substituents that are selected from halo, -OCH3, -OCHF2, -OCF3 and / o = O; or two Rw groups, when attached to the same nitrogen atom, can be linked together to form, together with the nitrogen atom to which they are necessarily attached, a 5 or 6 member ring, which optionally contains an additional heteroatom and which is optionally substituted with one or more substituents that are selected from fluorine, -CH3 and = O; t represents 1 or 2; p represents 0, 1 or 2; each R14 independently represents hydrogen, -Ax1-Bx1, C1-12 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said last three groups are optionally substituted with one or more substituents that are selected from E1; each R15 independently represents a direct bond, C1-12 alkylene or C2-12 alkenylene, where said last two groups are optionally substituted with one or more substituents that are selected from halo, -OCH3, -OCHF2, -OCF3 and = O; each R16 independently represents C1-12 alkyl, C2-6 alkenyl, C2-6 alkynyl (where said last three groups are optionally substituted with one or |
| priorityDate | 2007-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 54.