http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065333-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 |
| filingDate | 2008-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065333-A1 |
| titleOfInvention | RAPIDA DISOCIATION DOPAMINE 2 RECEIVER ANTAGONISTS |
| abstract | This refers to substituted 4-aryl-6-piperazin-1-yl-3-pyridazines that are rapidly dissociating dopamine 2 receptor antagonists, processes for preparing said compounds and pharmaceutical compositions comprising said compounds as active ingredient. The compounds are useful as medicines for the treatment or prevention of disorders of the central nervous system, for example, schizophrenia, exerting an antipsychotic effect without producing secondary motor effects. Claim 1: A compound of formula (1) or a stereoisomeric form thereof, in which R1 is chloro, trifluoromethyl or cyano; R2 is phenyl; phenyl substituted with 1, 2 or 3 substituents each of which is independently selected from the group consisting of halo, cyano, C1-4 alkyl, C1-4 alkyloxy, C1-4 alkyl sulfonyl, C1-4 perfluoroalkyl , C1-4 perfluoroalkyloxy, C1-4 dialkyl-amino, hydroxyl, and phenyl optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from the group consisting of halo, C1-4 alkyl and C1-4 perfluoroalkyl; thienyl; thienyl substituted with 1 or 2 substituents, each of which is independently selected from the group consisting of halo and C1-4 alkyl; naphthyl; pyridinyl; pyrrolyl; benzothiazolyl; indolyl; quinolinyl; C3-8 cycloalkyl or C5-7 cycloalkenyl; R3 is hydrogen, C1-4 alkyl, C1-4 alkyloxy or halo; R4 and R5 are each, independently, hydrogen or C1-4 alkyl, or R4 and R5 together form C1-4 alkanediyl; n is 1 or 2; and R 6 is hydrogen, C 1-4 alkyl, C 2-4 hydroxyalkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl, pyridinylmethyl, or phenylmethyl optionally substituted on the phenyl with 1, 2 or 3 substituents each which is independently selected from the group consisting of halo, cyano, C 1-4 alkyl, C 1-4 alkyloxy, C 1-4 alkyl sulfonyl, C 1-4 perfluoroalkyl, C 1-4 perfluoroalkyloxy and C 1-4 dialkyl; or R5 and R6 together form C2-5 alkanediyl; or a salt or solvate thereof acceptable for pharmaceutical use. |
| priorityDate | 2007-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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