http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065331-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee |
| filingDate | 2008-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a23d1b024c62591c434615e4e8206b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32e3e4bc17ca27014be3d30663d3a9b5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_401e35e72cae39c76fde88366eb272b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c693c8a953c4e4010af4611467d68e69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbe8dc04241d4ed47d74dcaae607b097 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a5a01a69280c60837af05a942c893e6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb0c757fe2e56dee0f67895a8bf62b58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0358873d115c3de0e3eb6c850da8ced http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc593327478e13e9b15a61e2f5c94181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ff1341512a953b658c1c11cceb70ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6eede9690038273e83d5a87c0f3e5718 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd51250aded4d1b38bc5b899ef5c52cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bad5d4263b43d799bbbe6912f9028dc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42eb2d757b504662a2fed57567fc2b6d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9005d42ce94c3f32fb86cd24ba38befe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4eceda00860fb4d0e14eb8030c9b28b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c9414b3a27a24ff5a22eba07f2b4c09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b1dafb5b25f87607cdca9031497705f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93865dc7e441cb3d6820c741a3579929 |
| publicationDate | 2009-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065331-A1 |
| titleOfInvention | DERIVATIVES OF BIFENILIL-1H-IMIDAZOL AND BIFENILDIIL-BIS (1H-IMIDAZOL-4,2) DIILO AS INHIBITORS OF THE VIRUS OF HEPATITIS C, COMPOSITIONS THAT UNDERSTAND AND THEIR USE IN THE TREATMENT OF AN INFECTION OF HCV. |
| abstract | Compounds, compositions and their use in the treatment of hepatitis C virus (HCV) infection. Also pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection. Claim 1: A compound characterized in that it is selected from ((1S) -2 - ((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2- ( N- (methoxycarbonyl) -L-alanyl) -2-azabicyclo [3,1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2 -azabicyclo [3.1.0] hex-2-yl) -1-methyl-2-oxoethyl) methyl carbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl (1R, 3S, 5R) -2-azabicyclo [3.1.0) hexane-3,2-diyl ((2S) -1-oxo-1 , 2- butanediyl))) dimethyl biscarbamate; (2- ((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - (((methoxycarbonyl) amino) acetyl) -2-azabicyclo [3.1 .0] hex-3-yl) - 1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex-2-yl) -2- oxoethyl) methyl carbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl (1R, 3S, 5R) -2-azabicyclo [3.1.0] hexane-3,2-diyl (1S) -1-cyclopropyl-2- dimethyl oxo-2,1-ethanediyl) biscarbamate; ((1R) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) - 2 - ((2R) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -2-azabicyclo [3.1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) - 1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex-2-yl) carbonyl) -2-methylopropyl) methyl carbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2- diyl (1R, 3S, 5R) -2-azabicyclo [3.1.0] hexane-3,2-diyl ((1R) -2-oxo-1-phenyl-2,1-ethanediyl))) dedimethyl biscarbamate; (( 1S) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2-acetyl-2-azabicyclo [3.1.0) hex- 3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex-2-yl) carbonyl) -2-methylopropyl) carbamate of methyl; (1S) -2-methyl-1 - (((1R, 3S, SR) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2- (5 - ((3aS, 4S, 6aR) -2-oxohexahydro-1H-thieno [3,4-d] imidazol-4-yl) pentanoyl) -2-azabicyclo [3.1.0] hex-3-yl) -1H-imidazol-4-yl ) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex-2-yl) carbonyl-2-methylopropyl) methyl carbamate; N - ((1S) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - ((2S) -2-acetamido -3-methylbutanoyl) -2-azabicyclo (3.1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1. 0] hex-2-yl) carbonyl) -2-methylopropyl) acetamide; (1S) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S , 5R) -2 - ((2S) -2 - ((tert-butoxycarbonyl) amino) -3-methylbutanoyl) -2-azabicyclo [3.1.0) hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex-2-yl) carbonyl) -2-methylopropyl) tert-butyl carbamate; (2S) -1 - ((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - ((2s) -2-amino-3-methylbutanoyl ) -2-azabicyclo [3.1.0) hex-3-yl) -1H-imidazol-5-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1.0] hex- 2-yl) -3-methyl-1-oxo-2-butanamine; N - ((1S) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - ((2S) -2- ( (cyclopropylcarbonyl) amino) -3-methylbutanoyl) -2-azabicyclo [3.1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2 -azabicyclo [3.1.0] hex-2-yl) carbonyl) -2-methylopropyl) cyclopropanecarbamate; (1R) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - ((2R) -2 - ((tert- butoxycarbonyl) amino) -3-methylbutanoyl) -2-azabicyclo [3.1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2- tert-butyl azabicyclo [3.1. 0] hex-2-yl) carbonyl) -2-methylopropyl) carbamate; N - ((1R) -1 - (((1R, 3S, 5R) -3- (4- (4 '- (2 - ((1R, 3S, 5R) -2 - ((2R) -2-acetamido -3-methylbutanoyl) -2-azabicyclo [3.1.0] hex-3-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -2-azabicyclo [3.1. 0] hex-2-yl) carbonyl) -2-methylopropyl) acetamide; N, N '- (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl (1R, 3S, 5R) -2-azabicyclo [3.1.0] hexane-3,2-diyl ((2S) - 3-methyl-1-oxo-1,2-butanediyl)) di (2-pyrimidinamine); ((1S) -1 - (((6S) -6- (4- (4 '- (2 - ((6S ) -5 - ((2S) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -5-azaspiro [2.4] hept-6-yl) -1H-imidazol-4-yl) -4-biphenylyl) - 1H-imidazol-2-yl) -5-azaspiro [2.4] hept-5-yl) carbonyl) -2-methylopropyl) methyl carbamate; (1S) -1 - (((2S, 5S) -2- (4 - (4 '- (2 - ((2S, 5S) -1 - ((2S) -2- (methoxycarbonyl) amino) -3-methylbutanoyl) -5-methyl-2-pyrrolidinyl) -1H-imidazol-4- il) -4-biphenylyl) -H-imidazol-2- yl) -5-methyl-1-pyrrolidinyl) carbonyl) -2-methylopropyl) methyl carbamate; (2 - ((6S) -6- (4- (4 '- (2 - ((6S) -5 - ((methoxycarbonyl) amino) acetyl) -5-azaspiro [2.4) hept-6-yl) -1H -imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-azaspiro [2.4] hept-5-yl) -2-oxoethyl) methyl carbamate; ((1S) -2 - ((6S) -6- (4- (4 '- (2 - ((6S) -5- (N- (methoxycarbonyl) -L-alanyl) -5-azaspiro [2.4] hept -6-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-azaspiro [2.4] hept-5-yl) -1-methyl-2-oxoethyl) methyl carbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl (6S) -5-azaspiro [2.4] heptane-6,5-diyl ((2S) -1-oxo-1,2-butanediyl)) ) dimethyl biscarbamate; ((1R) -1 - (((6S) -6- (4- (4 '- (2 - ((6S) -5 - ((2R) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -5-azaspiro [2.4) hept-6-yl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-azaspiro [2.4] hept-5-yl) carbonyl ) Methyl -2-methylopropyl) carbamate; (4,4 '-biphenyldiylbis (1H-imidazol-4,2-diyl (6S) -5-azaspiro [2.4] heptane-6,5-diyl ((1R) -2-oxo-1-phenyl-2,1 -etanediyl))) dimethyl biscarbamate; ((1R) -1 - (((2S, 5S) -2- (4- (4 - (2 - ((2S, 5S) -1 - ((2R) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -5-methyl-2-pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-methyl-1 methyl pyrrolidinyl) carbonyl) -2-methylopropyl) carbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl ((2S, 5S) -5-methyl-2,1-pyrrolidinediyl) ((1R) -2-oxo-1-phenyl-2,1 -etanediyl))) dimethyl biscarbamate; (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl ((2S, 5S) -5-methyl-2,1-pyrrolidinediyl) ((2S) -1-oxo-1,2-butanediyl)) ) dimethyl biscarbamate; (2 - ((2S, 5S) -2- (4- (4 '- (2 - ((2S, 5S) -1 - (((methoxycarbonyl) amino) acetyl) -5-methyl-2-pyrrolidinyl) - Methyl 1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-methyl-1-pyrrolidinyl) -2-oxoethyl) methyl carbamate; (2 - ((2S, 5S) -2- (4- (4 '- (2 - ((2S, 5S) -1- (2 - ((methoxycarbonyl) amino) -2-methylopropanoyl) -5-methy- 2-Pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-methyl-1-pyrrolidinyl) -1,1-dimethyl-2-oxoethyl) methyl carbamate ; ((1S) -2 - ((2S, 5S) -2- (4- (4 '- (2 - ((2S, 5S) -1- (N- (methoxycarbonyl) -L-alanyl) -5-methyl -2-Pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -1H-imidazol-2-yl) -5-methyl-1-pyrrolidinyl) -1-methyl-2-oxoethyl) methyl carbamate; 4,4 '- (4,4'-biphenyldiyl) bis (2 - ((2S, 5S) -5-methyl-1- (3-methylbutanoyl) -2-pyrrolidinyl) -1H-imidazole); 4,4 '- (4,4'-biphenyldiyl) bis (2 - ((2S, 5S) -5-methyl-1- (phenylacetyl) -2-pyrrolidinyl) -1H-imidazole); (2R, 2'R) -1,1 '- (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl ((2S, 5S) -5-methyl-2,1-pyrrolidinediyl))) bis (3-methyl-1-oxo-2-butanol); (2S, 2'S) -1,1 '- (4,4'-biphenyldiylbis (1H-imidazol-4,2-diyl ((2S, 5S) -5-methyl-2,1-pyrrolidinediyl))) bis (3 -methyl-1-oxo-2-butanol); 2 - ((2S, 5S) -1-acetyl-5-methyl-2-pyrrolidinyl) -4- (4 '- (2 - ((2S, 5S) -1-acetyl-5-methyl-2-pyrrolidinyl) -1H-imidazol-5-yl) -4-biphenylyl) -1H-imidazole; (2S) -2- (4- (4 '- (2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -4- (1,3-dioxan-2-ylmethyl) -1H- tert-butyl imidazol-5-yl) -4-biphenylyl) -1 H -imidazol-2-yl) -1-pyrrolidinecarboxylate; (2S) -2- (4- (4 '- (2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -4- (1,3-dioxolan-2-ylmethyl) -1H- tert -butyl imidazol-5-yl) -4-biphenylyl) -1 H -imidazol-2-yl) -1-pyrrolidinecarboxylate; (2S) -2- (4- (4 '- (2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -5- Tert-Butyl (2-methoxy-2-oxoethyl) -1 H -imidazol-2-yl) -1-pyrrolidinecarboxylate; (2S) -2- (4- (4 '- (2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -5- tert-butyl propyl-1H-imidazol-2-yl) -1-pyrrolidinecarboxylate; 2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -5- (4 '- (2- ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -1H-imidazole -5-yl) -4-biphenylyl) -1H-ethyl imidazol-4-carboxylate; (2S) -2- (4- (4 '- (2 - ((2S) -1- (tert-butoxycarbonyl) -2-pyrrolidinyl) -1H-imidazol-4-yl) -3'-fluoro-4- tert-butyl biphenylyl) -1H-imidazol-2-yl) -4,4-difluoro-1-pyrrolidinecarboxylate; 2 - ((2S) -4,4-difluoro-2-pyrrolidinyl) -4- (3'-fluoro-4 '- (2- (2S) -2-pyrrolidinyl) -1H-imidazol-4-yl) - 4-biphenylyl) -1H-imidazole; (1R) -2 - ((2S) -2- (4- (4 '- (2 - ((2S) -1 - ((2R) -2- (diethylamino) -2-phenylacetyl) -2-pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -5-methyl-1H-imidazol-2-yl) -1-pyrrolidinyl) -N, N-diethyl-2-oxo-1-phenylethanamine; 1- ((1R) -2 - ((2S) -2- (4- (4 '- (4-methyl-2 - ((2S) -1 - ((2R) -2-phenyl-2- (1 -piperidinyl) acetyl) -2-pyrrolidinyl) -1H-imidazol-5-yl) -4-biphenylyl) -1H-imidazol-2-yl) -1-pyrrolidinyl) -2-oxo-1-phenylethyl) piperidine; ((1R) -2 - ((2S) -2- (4- (4 '- (2 - ((2S) -1 - ((2R) -2 - ((methoxycarbonyl) amino) -2-phenylacetyl) - Methyl 2-pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl-5-methyl-1H-imidazol-2-yl) -1-pyrrolidinyl) -2-oxo-1-phenylethyl) carbamate; (1S) -2 - ((2S) -2- (4- (4 '- (2 - ((2S) -1- (N- (methoxycarbonyl) -L-alanyl) -2-pyrrolidinyl) -4-methyl -1H-imidazol-5-yl) -4-biphenylyl) -1H-imidazol-2-yl) -1-pyrrolidinyl) -1-methyl-2-oxoethyl) methyl carbamate; ((1S) -1 - (((2S) -2- (4- (4 '- (2 - ((2S) -1 - ((2S) -2 - ((methoxycarbonyl) amino) -3-methylbutanoyl) -2-Pyrrolidinyl) -1H-imidazol-4-yl) -4-biphenylyl) -5-metii-1H-imidazol-2-yl) -1-pyrrolidinyl) carbonyl) -2-methylopropyl) methyl carbamate; ((1S, 2R) -2-methoxy-1 - (((2S) -2- (4- (4 '- (2 - ((2S) -1- (N- (methoxycarbonyl-O-methyl-L- threonyl) -2-pyrrolidinyl) -4-methyl-1H-imidazol-5-yl) -4-biphenylyl) -1H-imidazol-2-yl) -1-pyrrolidinyl) carbonyl) propyl) methyl carbamate; (1R, 1'R) -2,2 '- (4,4'-biphenyldiylbis ((4-methyl-1H-imidazol-5,2-diyl) (2S) -2,1-pyrrolidinediyl)) bis (N, N- dimethyl-2-oxo-1-phenylethanamine); (1R, 1'R) -2,2 '- (4,4'-biphenyldiylbis ((4-methyl-1H-imidazol-5,2-diyl) (2S) -2,1-pyrrolidinediyl)) bis (N, N-diethyl-2-oxo-1-phenylethanamine); 1,1 '- (4,4'-biphenyldiylbis ((4-methyl-1H-imidazol-5.2 -diyl) (2S) -2,1-pyrrolidinediyl ((1R) -2-oxo-1-phenyl-2,1-ethanediyl))) dipiperidine; (4,4'-biphenyldiylbis ((4-methyl-1H- imidazol-5,2-diyl) (2S) -2,1-pyrrolidinediyl ((1R) -2-oxo-1-phenyl-2,1-ethanediyl))) dimethyl biscarbamate; ((1S) -2- ( (2S) -2- (4- (4 '- (2 - ((2S) -1- (N- (methoxycarbonyl) -L-alanyl) -2-pyrrolidinyl) -5-methyl-1H-imidazol-4- il) -4-biphenylyl) -5-methyl-1-imidazol-2-yl) -1-pyrrolidinyl) -1-methyl-2-oxoethyl) methyl carbamate; ((1S) -1- (((2S) -2- (4- (4 '- (2 - ((2S) -1 - ((2S) -2 - ((methoxycarb onyl) amino) -3-methylbutanoyl) -2-pyrrolidinyl) -4-methyl-H-imidazol-5-yl) -4-biphenylyl) -5-methyl-1H-imidazol-2-yl) -1-pyrrolidinyl) methyl carbonyl) -2-methylopropyl) carbamate; ((1S, 2R) -2-methoxy-1 - (((2S) -2- (4- (4 '- (2 - ((2S) -1- (N- (methoxycarb |
| priorityDate | 2008-02-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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