| abstract |
Compound of 2-oxo-1-oxa-3-azaspiro [4,5) decan-3-yl of the formula (1) or a pharmaceutically acceptable salt or solvate thereof, wherein: R is an aryl or heteroaryl; which may be substituted with one or more: halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, cyano; Z1 is H, C1-4 alkyl or F; Z is CH2, CH (C1-4 alkyl), C (C1-4 alkyl) 2 or a bond; A is a 5-membered heteroaryl, which may be substituted with one or more: halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, cyano; B is hydrogen or is a 5-6 membered heteroaryl, or phenyl, which may be substituted with one or more: halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, cyano; being A and B united through any atom. Its use for the manufacture of a useful drug to treat a pathological condition modulated by NPY Y5 receptors, such as eating disorders, such as overeating, obesity and depression. Pharmaceutical composition that includes it. |