http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-065079-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_77a01b013bb851155e9a4c7c24a93fdf |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-96 |
| filingDate | 2008-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c3061e36a31b4bcb242a26a2d89da4a |
| publicationDate | 2009-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-065079-A1 |
| titleOfInvention | PROCESSES FOR THE PREPARATION OF N- (1-ACILPIPERIDIN-4-IL) -N '- (ADAMANT-1-IL) UREA AND INTERMEDIARIES OF THESE PROCESSES. |
| abstract | Processes for the synthesis of piperidinyl substituted urea compounds are described. Intermediates prepared during this synthesis are also provided. Claim 1: A process for the preparation of urea compounds of the formula (1), wherein R 1 is selected from the group consisting of alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclic and substituted heterocyclic, and m is zero, 1 or 2; characterized in that it comprises: a) contacting at least an equimolar amount of a compound of the formula (2) R1C (O) X where X is -OH, halo or -OC (O) R, where R is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclic, or substituted heterocyclic, with a compound of the formula (3), in an inert solvent under conditions that provide a compound of the formula (4) , b) contacting the compound of the formula (4) produced in a) above with adamantylamine in the presence of an inert solvent and a reagent that converts the H2NC (O) -amido group of the compound of the formula (4) into a isocyanate group under conditions in which the isocyanate group reacts with the amine of said adamantylamine group to form the compound of the formula (1). Claim 14: A compound of the formula (8a) or (8b) characterized in that it is -CO-W, -SO2-W, or W, wherein W is alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclic, or substituted heterocyclic, with the proviso that in formula (8a) R7 is not -COCF3, -CH2-C6H5, or formula (11). Claim 15: A compound of the formula (9) wherein R8 is C1-6 alkyl. Claim 16: A compound of the formula (10), characterized in that R9 is C1-6 alkyl. |
| priorityDate | 2007-01-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.