http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-064424-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D237-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| filingDate | 2007-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-064424-A1 |
| titleOfInvention | SUBSTITUTED DERIVATIVES OF 1-OXO-FTALAZINAS and 1-OXO-PIRIDO-PIRIDAZINAS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USES TO PREVENT AND / OR TREAT INFLAMMATORY AND ALLERGIC DISEASES OF RESPIRATORY TRACT. |
| abstract | Claim 1: A compound of formula (1) in which: A represents N or CH; R1 and R2 each independently represent halogen, C1-3 alkyl, C1-3 alkoxy, hydroxy or trifluoromethyl; x e y each independently represent 0, 1 or 2; m represents 0, n represents 2 and p represents 1; or m represents 1, n represents 0 and p represents 2; R3 represents a straight chain C1-6 alkylene optionally substituted with one or two C1-3 alkyl; and R4 represents a group of formula (1), (2), (3) or (4); (1) -C (O) N (R5) R6 in which R5 represents hydrogen or -C1-6 alkyl; R6 represents hydrogen; - C1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); -C 1-6 alkyl-O-C 1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); C3-7 cycloalkyl (optionally substituted with up to three substituents independently selected from halogen, hydroxy and C1-3 alkyl); -C 1-3 alkyl-C 3-7 cycloalkyl (wherein the C 1-3 alkyl is optionally substituted with up to three substituents independently selected from halogen and hydroxy, and the C 3-7 cycloalkyl is optionally substituted with up to three substituents independently selected from halogen , hydroxy and C1-3 alkyl); aryl (optionally substituted with up to three substituents independently selected from halogen, C1-3 alkyl, trifluoromethyl and cyano); - C1-6 alkyl-aryl (wherein C1-6 alkyl is optionally substituted with up to three substituents independently selected from C1-3 alkyl, halogen and hydroxy, and the aryl is optionally substituted with up to three substituents independently selected from halogen, C1-3 alkyl, trifluoromethyl and cyano); or - (C-1-3 alkyl) zHet, wherein z represents 0 or 1 and Het represents a saturated 5- to 7-membered heterocyclic ring containing one or two heteroatoms independently selected from O and S; or R5 and R6, together with the N atom to which they are attached, represent a saturated 5- to 7-membered heterocyclic ring that optionally contains one or two heteroatoms more independently selected from O and S; (2) -N (R7) C (O) R8 in which R7 represents hydrogen or -C1-6 alkyl; and R 8 represents -C 1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); -C 1-6 alkyl-O-C 1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); C3-7 cycloalkyl (optionally substituted with up to three substituents independently selected from halogen, hydroxy and C1-3 alkyl); -C 1-3 alkyl-C 3-7 cycloalkyl (wherein the C 1-3 alkyl is optionally substituted with up to three substituents independently selected from halogen and hydroxy, and the C 3-7 cycloalkyl is optionally substituted with up to three substituents independently selected from halogen , hydroxy and C1-3 alkyl); aryl (optionally substituted with up to three substituents independently selected from halogen, C1-3 alkyl, trifluoromethyl and cyano); -C 1-6 alkyl-aryl (wherein the C 1-6 alkyl is optionally substituted with up to three substituents independently selected from C 1-3 alkyl, halogen and hydroxy, and the aryl is optionally substituted with up to three substituents independently selected from halogen, C1-3 alkyl, trifluoromethyl and cyano); or - (C1-3 alkyl) zHet, in which z represents 0 or 1 and Het represents a saturated 5- to 7-membered heterocyclic ring containing one or two heteroatoms independently selected from O and S; formula (3) in which c represents 0 or 1 and d represents 2 or 3, or c represents 2 or 3 and d represents 0 or 1; and R9 represents hydrogen or C1-6 alkyl; formula (4) in which R 10 represents hydrogen, or -C 1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); -C 1-6 alkyl-O-C 1-6 alkyl (optionally substituted with up to three substituents independently selected from halogen and hydroxy); aryl (optionally substituted with up to three substituents independently selected from halogen, C1-3 alkyl, trifluoromethyl and cyano); or -C 1-6 alkyl-aryl (wherein the C 1-6 alkyl is optionally substituted with up to three substituents independently selected from C 1-3 alkyl, halogen and hydroxy, and the aryl is optionally substituted with up to three substituents independently selected from halogen , C1-3 alkyl, trifluoromethyl and cyano); or a salt thereof. |
| priorityDate | 2006-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 20.