http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-064357-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| filingDate | 2007-12-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-064357-A1 |
| titleOfInvention | PURIFICATION OF A ALFA-CETUS BISULPHITE |
| abstract | Claim 1: A process for purifying the compound of formula 1, process comprising: a) extracting an organic phase comprising: (i) the compound of formula 1; and (ii) one or more organic solvents, with an aqueous bisulfite solution, whereby an aqueous phase comprising a bisulfite adduct of the compound of formula 1 is formed; and b) regenerating the compound of formula 1 as a precipitate by: (i) a process comprising: (1) extracting the aqueous phase containing the bisulfite adduct of the compound of formula 1 provided in the ôaö step with an organic phase that it comprises one or more water-miscible organic solvents, whereby an organic phase is formed containing the compound of formula 1; and (2) mixing the isolated organic phase provided in the extraction step (b) (i) (1) with water at a temperature suitable for precipitating the compound of formula 1; or (ii) adding the aqueous phase prepared in step (a) to an organic phase comprising one or more water-miscible organic solvents, whereby the compound of formula 1 is precipitated; or (iii) adding to the aqueous phase provided in step (a) a carbonyl compound or an oxidant suitable for precipitating the compound of formula 1; or (iv) a regeneration process comprising: (1) extracting the aqueous phase provided in step (a) with an organic phase comprising at least one organic solvent and optionally a carbonyl compound or an oxidizing compound; and (2) adding the organic phase obtained in the extraction step (b) (iv) (1) to a solvent or a mixture of solvents in which the compound of formula 1 is insoluble (an anti-solvent) at a temperature suitable for precipitate the compound of formula 1. |
| priorityDate | 2006-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 15.