http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-064198-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 |
| filingDate | 2007-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2009-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-064198-A1 |
| titleOfInvention | PIPIDIDYLAMINE PIRIDAZINAS AS ANTAGONISTS OF THE DOPAMINE 2 RECEPTOR OF RAPIDA DISOCIACION. PROCESSES OF OBTAINING AND PHARMACEUTICAL COMPOSITIONS |
| abstract | This refers to 6- (piperidin-4-ylamino) pyridazin-3-carbonitriles which are rapidly dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as active ingredient. The compounds find utility as medications to treat or prevent disorders of the central nervous system, for example schizophrenia, when exerting an antipsychotic effect without motor side effects. Claim 1: A compound of formula (1) or a pharmaceutically acceptable salt or solvate thereof, or one of its (stereoisomeric urine, in which R is hydrogen or C1-6 alkyl; R1 is phenyl; phenyl substituted with 1, 2 or 3 substituents each independently selected from the group consisting of hydrogen, halo, cyano, C1-4 alkyl, C1-4 alkoxy, C1-4 perfluoroalkyl, and trifluoromethoxy; thienyl; thienyl substituted with 1 or 2 substituents selected from the group consisting of halo and C1-4 alkyl; C1-4 alkyl; C1-4 alkyl substituted with hydroxyl, C3-8 cycloalkyl or C5-7 cycloalkenyl; C3-8 cycloalkyl or C5-7 cycloalkenyl; R2 is hydrogen or C1-6 alkyl; R3 and R4 are each independently hydrogen, C1-4 alkyl or halo, or R3 and R4 together form a 5, 6 or 7 membered carbocyclic ring or a 5, 6 or 7 membered heterocyclic ring which comprises at least one oxygen, nitrogen or sulfur atom. |
| priorityDate | 2006-12-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 27.