http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-063569-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_12a9e9ce63eb0bbf3658453fb50a6d9b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H7-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-2018 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-4866 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 |
| filingDate | 2007-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_64c252397804123d7b339fb173296d12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_228101d75caf3d1d347888e562589f0e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed858ecc6fa2e2ed5b66f553f449be4b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bec842f35e2eac1077005183a68e789 |
| publicationDate | 2009-02-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-063569-A1 |
| titleOfInvention | DERIVATIVES OF BENZIL- BENZONITRILE SUBSTITUTED WITH GLUCOPYRANOSIL MEDICINES CONTAINING COMPOUNDS OF THIS TYPE ITS USE OR PROCEDURE FOR MANUFACTURING |
| abstract | Pharmaceutical composition, use for disorders by inhibition of the sodium dependent glucose transporter SGLT, process, and intermediates. Claim 1: Glucopyranosyl substituted benzyl benzonitrile derivatives of the general formula 1 wherein R2 indicates fluoro, chloro, bromo, iodo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C3- cycloalkyl 7-C 1-3 alkyl, hydroxy, C 1-4 alkoxy, C 3-7 cycloalkyloxy, C 5-7 cycloalkenyloxy, C 1-4 alkylsulfanyl, amino, nitro or cyano, while alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl moieties mentioned above may be mono- or poly-substituted with fluoro and / or mono- or di-substituted with identical or different L2 substituents, and while in the aforementioned C5-6 cycloalkyl and C5-6 cycloalkenyl rings one or two groups mentioned above Methylene may be replaced, independently of one another, by O, S, CO, SO or SO2, and R3 means hydrogen, fluoro, chloro, bromo, iodo, C1-6 alkyl, C2-6 alkynyl, C2-6 alkenyl, cycloalkyl C3-7, C3-7 cycloalkyl-C1-3 alkyl, C5-7 cycloalkenyl, C5-7 cycloalkenyl-C1-3 alkyl, aryl, het eroaryl, C1-4 alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, C1-4alkylcarbonyl, di- (C1-3alkyl) aminocarbonyl, pyrrolidin-1-ylcarbonyl, piperidin-1-ylcarbonyl, morpholin-4-ylcarbonyl, piperazin-1-ylcarbonyl, 4- (C1-4 alkyl) piperazin-1-ylcarbonyl, hydroxycarbonyl, C1-4 alkoxycarbonyl, C1-4 alkyl-amino, di- (C1-3 alkyl) amino, pyrrolidin-1- ilo, piperidin-1-yl, morpholin-4-yl, piperazin-1-yl, 4- (C1-4 alkyl) piperazin-1-yl, C1-4 alkylcarbonylamino, arylcarbonylamino, heteroarylcarbonylamino, C1-4 alkyl suIphonylamino, arylsulfonylamino, C1-6 alkoxy, C3-7 cycloalkyloxy, C5-7 cycloalkenyloxy, aryloxy, heteroaryloxy, C1-4-sulfanyl alkyl, C1-4-sulfinyl, C1-4-sulfonyl alkyl, C3-7-sulfanyl cycloalkyl , C3-7-sulfinyl cycloalkyl, C3-7-sulfonyl cycloalkyl, C5-7-sulfanyl, C5-7-sulfinyl cycloalkenyl, C5-7-sulfonyl cycloalkenyl, arylsulfanyl, arylsulfinyl, arylsulfonyl, heteroarylsulfanyl, heteroarylsulfin Eteroarylsulfonyl, amino, hydroxy, cyano and nitro, while the above-mentioned alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl moieties may be mono- or poly-substituted with fluoro and / or mono- or di-substituted with identical or different L2 substituents , and while in the above-mentioned C5-6 cycloalkyl and C5-6 cycloalkenyl rings one or two methylene groups may be replaced, independently of one another, by O, S, CO, SO or SO2, and while in the rings of the above-mentioned N-heterocycloalkyl a methylene group may be replaced by CO or SO2, and R4, R5, independently of one another, indicate hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, C1-3 alkyl, C1-3 alkoxy , or a methyl or methoxy group substituted with 1 to 3 fluorine atoms, L1 independently from each other, is selected from fluorine, chlorine, bromine, iodine, hydroxy, cyano, C1-3 alkyl, difluoromethyl, trifluoromethyl, C1-3 alkoxy, difluoromethoxy, trifluoromethoxy, amino, (alkyl C1-3) -amino and di (C1-3 alkyl) -amino; and L2, independently from each other, is selected from fluorine, chlorine, hydroxy, hydroxyC 1-4 alkyl, C 1-4 alkoxy, trifluoromethoxy, C 1-4 alkoxy-C 1-4 alkyl, cyano, hydroxycarbonyl, (C 1-4 alkyl) oxycarbonyl, aminocarbonyl, C1-4 alkyl, trifluoromethyl, amino, C1-4 alkylcarbonylamino, C1-3 alkyl and di (C1-3 alkyl) -amino; and R6, R7a, R7b, R7c, independently of one another, have a meaning selected from hydrogen, (C1-18 alkyl) carbonyl, (C1-18 alkyl) oxycarbonyl, arylcarbonyl and aryl (C1-3 alkyl) -carbonyl, in the that aryl groups may be mono- or disubstituted independently of each other with the same or different L1 groups; while by the aryl groups mentioned in the definition of the above groups, phenyl or naphthyl groups are understood to be substituted as defined; and while, unless otherwise indicated, the aforementioned alkyl groups may be straight or branched chain, including their tautomers, stereoisomers or mixtures thereof, and their physiologically acceptable salts. Claim 17: A compound of general formula 6 wherein Hal indicates chlorine, bromine or iodine, R1 indicates cyano, chlorine or bromine and the groups R2 and R5 are defined as in claim 1. Claim 18: a compound of general formula 2 in wherein R ', R8a, R8b, R8c, R8d and R1 to R5 are defined as in claim 16. |
| priorityDate | 2006-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.