| abstract |
Het represents a mono or bicyclic heterocycle, of 1 to 4 heteroatoms chosen from N, O or S, opclonally substituted; R1 represents X- (AB) n-CONH2, X- (AB) nO-CONH2, X- (AB) n-NRCONH2, X- (CH2) m-heterocycloalkyl, X- (CH2) m-aryl and X- ( CH2) m- heteroaryl with X representing -OC (O), -NH-C (O), NH-CS, -NH-CO-CH2-O-; -NH-CO-CH2-S-CH2-CO-NH-; -NH-CO- (CH2) 2-SO2-; -NH-CO-CH2-N (CH3) -CO-; A and B represent a single bond, CH2, CH-alkyl, CH-aralkyl, n = 1.2 and m = 0.1; R2 and R2 represent H, halogen, CF3, nitro, cyano, alkyl, hydroxy, mercapto, amino, alkylamino, dialkylamino, alkoxy, alkylthio, free carboxy or esterified by an alkyl, carboxamide, CO-NH (alkyl) radical and NH-COalkyl; p = 1 to 4 and p '= 1 to 3; L represents a single bond, CH2, C (O), O, S or NH, all these radicals being optionally substituted; these products being in all isomeric forms and salt forms, such as medicines. |